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Philip Newsholme
Philip Newsholme
Professor of Biomedical Sciences
E-mail confirmado em curtin.edu.au
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
SL Masters, A Dunne, SL Subramanian, RL Hull, GM Tannahill, FA Sharp, ...
Nature immunology 11 (10), 897-904, 2010
14112010
Glutamine: metabolism and immune function, supplementation and clinical translation
V Cruzat, M Macedo Rogero, K Noel Keane, R Curi, P Newsholme
Nutrients 10 (11), 1564, 2018
8372018
Glutamine and glutamate—their central role in cell metabolism and function
P Newsholme, J Procopio, MMR Lima, TC Pithon‐Curi, R Curi
Cell biochemistry and function 21 (1), 1-9, 2003
8112003
Diabetes associated cell stress and dysfunction: role of mitochondrial and non‐mitochondrial ROS production and activity
P Newsholme, EP Haber, SM Hirabara, ELO Rebelato, J Procopio, ...
The Journal of physiology 583 (1), 9-24, 2007
7922007
Why is L-glutamine metabolism important to cells of the immune system in health, postinjury, surgery or infection?
P Newsholme
The Journal of nutrition 131 (9), 2515S-2522S, 2001
7892001
Molecular mechanisms of ROS production and oxidative stress in diabetes
P Newsholme, VF Cruzat, KN Keane, R Carlessi, PIH de Bittencourt Jr
Biochemical Journal 473 (24), 4527-4550, 2016
7792016
Molecular mechanisms of glutamine action
R Curi, CJ Lagranha, SQ Doi, DF Sellitti, J Procópio, TC Pithon‐Curi, ...
Journal of cellular physiology 204 (2), 392-401, 2005
5752005
Glutamine and glutamate as vital metabolites
P Newsholme, MMR Lima, J Procópio, TC Pithon-Curi, RB Bazotte, R Curi
Brazilian journal of medical and biological research 36, 153-163, 2003
5082003
Metabolism of glucose, glutamine, long-chain fatty acids and ketone bodies by murine macrophages
P Newsholme, R Curi, S Gordon, EA Newsholme
Biochemical Journal 239 (1), 121-125, 1986
4791986
The impact of vitamin D levels on inflammatory status: a systematic review of immune cell studies
EK Calton, KN Keane, P Newsholme, MJ Soares
PloS one 10 (11), e0141770, 2015
4122015
Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease
G Verdile, KN Keane, VF Cruzat, S Medic, M Sabale, J Rowles, ...
Mediators of inflammation 2015, 2015
3972015
Molecular events linking oxidative stress and inflammation to insulin resistance and β-cell dysfunction
KN Keane, VF Cruzat, R Carlessi, PIH De Bittencourt, P Newsholme
Oxidative medicine and cellular longevity 2015, 2015
3842015
Rates of utilization and fates of glucose, glutamine, pyruvate, fatty acids and ketone bodies by mouse macrophages
P Newsholme, S Gordon, EA Newsholme
Biochemical Journal 242 (3), 631-636, 1987
3511987
New insights into amino acid metabolism, β-cell function and diabetes
P Newsholme, L Brennan, B Rubi, P Maechler
Clinical science 108 (3), 185-194, 2005
3292005
Effect of low‐to‐moderate amounts of dietary fish oil on neutrophil lipid composition and function
DA Healy, FA Wallace, EA Miles, PC Calder, P Newsholme
Lipids 35 (7), 763-768, 2000
2872000
Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line
D Morgan, HR Oliveira-Emilio, D Keane, AE Hirata, M Santos da Rocha, ...
Diabetologia 50, 359-369, 2007
2652007
Regulation of SIRT1 in aging: roles in mitochondrial function and biogenesis
Y Yuan, VF Cruzat, P Newsholme, J Cheng, Y Chen, Y Lu
Mechanisms of ageing and development 155, 10-21, 2016
2552016
Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages in culture
P Newsholme, EA Newsholme
Biochemical Journal 261 (1), 211-218, 1989
2511989
Nutrient regulation of insulin secretion and action
P Newsholme, V Cruzat, F Arfuso, K Keane
Journal of Endocrinology 221 (3), R105-R120, 2014
2502014
Amino acid metabolism, insulin secretion and diabetes
P Newsholme, K Bender, A Kiely, L Brennan
Biochemical Society Transactions 35 (5), 1180-1186, 2007
2402007
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Artigos 1–20