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Hsin-Yi Chen
Hsin-Yi Chen
E-mail confirmado em wistar.org
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Autophagy suppresses tumorigenesis through elimination of p62
R Mathew, CM Karp, B Beaudoin, N Vuong, G Chen, HY Chen, K Bray, ...
Cell 137 (6), 1062-1075, 2009
19562009
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
JY Guo, HY Chen, R Mathew, J Fan, AM Strohecker, G Karsli-Uzunbas, ...
Genes & development 25 (5), 460-470, 2011
14282011
Role of autophagy in cancer prevention
HY Chen, E White
Cancer Prevention Research 4 (7), 973-983, 2011
2292011
Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma
J Villanueva, JR Infante, C Krepler, P Reyes-Uribe, M Samanta, HY Chen, ...
Cell reports 4 (6), 1090-1099, 2013
2142013
Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition
K Bray, R Mathew, A Lau, JJ Kamphorst, J Fan, J Chen, HY Chen, ...
PloS one 7 (7), e41831, 2012
1612012
Compounds from Wedelia chinensis synergistically suppress androgen activity and growth in prostate cancer cells
FM Lin, LR Chen, EH Lin, FC Ke, HY Chen, MJ Tsai, PW Hsiao
Carcinogenesis 28 (12), 2521-2529, 2007
1452007
Bcl-2 modulation to activate apoptosis in prostate cancer
K Bray, HY Chen, CM Karp, M May, S Ganesan, V Karantza-Wadsworth, ...
Molecular Cancer Research 7 (9), 1487-1496, 2009
572009
Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma
C Krepler, M Xiao, M Samanta, A Vultur, HY Chen, P Brafford, ...
Oncotarget 7 (44), 71211, 2016
292016
Double Trouble: Kinase domain duplication as a new path to drug resistance
HY Chen, DC Brady, J Villanueva
Pigment Cell & Melanoma Research 29 (5), 493-495, 2016
72016
Playing Polo-Like Kinase in NRAS-Mutant Melanoma
HY Chen, J Villanueva
Journal of Investigative Dermatology 135 (10), 2352-2355, 2015
52015
Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRASmut melanoma
HY Chen, AR Goldman, D Zayas-Bazan, PI Reyes-Uribe, AN Guterres, ...
bioRxiv, 2021
12021
Loss of S6K2 perturbs redox balance and fatty acid metabolism, leading to oxidative cell death
HY Chen, M Samanta, P Reyes-Uribe, AV Kossenkov, X Yin, Y Lu, ...
Cancer Research 78 (13 Supplement), 2381-2381, 2018
12018
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