Karun K Singh
Karun K Singh
Krembil Research Institute, University Health Network (Toronto), University of Toronto
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Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3β/β-catenin signaling
Y Mao, X Ge, CL Frank, JM Madison, AN Koehler, MK Doud, C Tassa, ...
Cell 136 (6), 1017-1031, 2009
Developmental axon pruning mediated by BDNF-p75NTR–dependent axon degeneration
KK Singh, KJ Park, EJ Hong, BM Kramer, ME Greenberg, DR Kaplan, ...
Nature neuroscience 11 (6), 649-658, 2008
Understanding the role of DISC1 in psychiatric disease and during normal development
NJ Brandon, JK Millar, C Korth, H Sive, KK Singh, A Sawa
Journal of Neuroscience 29 (41), 12768-12775, 2009
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits
E Kelly, F Meng, H Fujita, F Morgado, Y Kazemi, LC Rice, C Ren, ...
Nature neuroscience 23 (9), 1102-1110, 2020
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development
KK Singh, X Ge, Y Mao, L Drane, K Meletis, BA Samuels, LH Tsai
Neuron 67 (1), 33-48, 2010
Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling
M Richter, N Murtaza, R Scharrenberg, SH White, O Johanns, S Walker, ...
Molecular psychiatry 24 (9), 1329-1350, 2019
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development
KK Singh, G De Rienzo, L Drane, Y Mao, Z Flood, J Madison, M Ferreira, ...
Neuron 72 (4), 545-558, 2011
Complete disruption of autism-susceptibility genes by gene editing predominantly reduces functional connectivity of isogenic human neurons
E Deneault, SH White, DC Rodrigues, PJ Ross, M Faheem, K Zaslavsky, ...
Stem cell reports 11 (5), 1211-1225, 2018
Wnt signaling networks in autism spectrum disorder and intellectual disability
V Kwan, BK Unda, KK Singh
Journal of neurodevelopmental disorders 8, 1-10, 2016
Semaphorin 3F antagonizes neurotrophin-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase signaling: a mechanism for growth cone collapse
JK Atwal, KK Singh, M Tessier-Lavigne, FD Miller, DR Kaplan
Journal of Neuroscience 23 (20), 7602-7609, 2003
Single transcription factor conversion of human blood fate to NPCs with CNS and PNS developmental capacity
JH Lee, RR Mitchell, JD McNicol, Z Shapovalova, S Laronde, ...
Cell reports 11 (9), 1367-1376, 2015
Activity regulates positive and negative neurotrophin-derived signals to determine axon competition
KK Singh, FD Miller
Neuron 45 (6), 837-845, 2005
OTUD7A regulates neurodevelopmental phenotypes in the 15q13. 3 microdeletion syndrome
M Uddin, BK Unda, V Kwan, NT Holzapfel, SH White, L Chalil, ...
The American Journal of Human Genetics 102 (2), 278-295, 2018
CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks
E Deneault, M Faheem, SH White, DC Rodrigues, S Sun, W Wei, ...
Elife 8, e40092, 2019
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin
O Durak, FC de Anda, KK Singh, MP Leussis, TL Petryshen, P Sklar, ...
Molecular psychiatry 20 (3), 388-397, 2015
An emerging role for Wnt and GSK3 signaling pathways in schizophrenia
KK Singh
Clinical genetics 83 (6), 511-517, 2013
A patient-derived cellular model for Huntington’s disease reveals phenotypes at clinically relevant CAG lengths
CLK Hung, T Maiuri, LE Bowie, R Gotesman, S Son, M Falcone, ...
Molecular Biology of the Cell 29 (23), 2809-2820, 2018
Adult skin-derived precursor Schwann cells exhibit superior myelination and regeneration supportive properties compared to chronically denervated nerve-derived Schwann cells
R Kumar, S Sinha, A Hagner, M Stykel, E Raharjo, KK Singh, R Midha, ...
Experimental neurology 278, 127-142, 2016
DIXDC1 phosphorylation and control of dendritic morphology are impaired by rare genetic variants
V Kwan, DP Meka, SH White, CL Hung, NT Holzapfel, S Walker, ...
Cell reports 17 (7), 1892-1904, 2016
Report of the first patient with a homozygous OTUD7A variant responsible for epileptic encephalopathy and related proteasome dysfunction
P Garret, F Ebstein, G Delplancq, B Dozieres‐Puyravel, A Boughalem, ...
Clinical Genetics 97 (4), 567-575, 2020
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