| Biocatalytic reductions and chemical versatility of the old yellow enzyme family of flavoprotein oxidoreductases HS Toogood, JM Gardiner, NS Scrutton ChemCatChem 2 (8), 892-914, 2010 | 322 | 2010 |
| CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane S Barcelo, JM Gardiner, A Gescher, JK Chipman Carcinogenesis 17 (2), 277-282, 1996 | 276 | 1996 |
| Asymmetric reduction of activated alkenes by pentaerythritol tetranitrate reductase: specificity and control of stereochemical outcome by reaction optimisation A Fryszkowska, H Toogood, M Sakuma, JM Gardiner, GM Stephens, ... Advanced synthesis & catalysis 351 (17), 2976-2990, 2009 | 136 | 2009 |
| Highly Enantioselective Reduction of β,β-Disubstituted Aromatic Nitroalkenes Catalyzed by Clostridium sporogenes A Fryszkowska, K Fisher, JM Gardiner, GM Stephens The Journal of organic chemistry 73 (11), 4295-4298, 2008 | 117 | 2008 |
| Structure‐based insight into the asymmetric bioreduction of the C C double bond of α, β‐unsaturated nitroalkenes by pentaerythritol tetranitrate reductase HS Toogood, A Fryszkowska, V Hare, K Fisher, A Roujeinikova, D Leys, ... Advanced synthesis & catalysis 350 (17), 2789-2803, 2008 | 104 | 2008 |
| Free energy landscapes of iduronic acid and related monosaccharides BM Sattelle, SU Hansen, J Gardiner, A Almond Journal of the American Chemical Society 132 (38), 13132-13134, 2010 | 101 | 2010 |
| An updated synthesis of the diazo-transfer reagent imidazole-1-sulfonyl azide hydrogen sulfate GT Potter, GC Jayson, GJ Miller, JM Gardiner The Journal of Organic Chemistry 81 (8), 3443-3446, 2016 | 98 | 2016 |
| Making the longest sugars: a chemical synthesis of heparin-related [4] n oligosaccharides from 16-mer to 40-mer SU Hansen, GJ Miller, MJ Cliff, GC Jayson, JM Gardiner Chemical science 6 (11), 6158-6164, 2015 | 97 | 2015 |
| Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor C Ferreras, G Rushton, CL Cole, M Babur, BA Telfer, TH Van Kuppevelt, ... Journal of Biological Chemistry 287 (43), 36132-36146, 2012 | 93 | 2012 |
| Enzymatic Menthol Production: One-Pot Approach Using Engineered Escherichia coli HS Toogood, AN Cheallaigh, S Tait, DJ Mansell, A Jervis, A Lygidakis, ... ACS Synthetic Biology 4 (10), 1112-1123, 2015 | 85 | 2015 |
| A site‐saturated mutagenesis study of pentaerythritol tetranitrate reductase reveals that residues 181 and 184 influence ligand binding, stereochemistry and reactivity HS Toogood, A Fryszkowska, M Hulley, M Sakuma, D Mansell, ... ChemBioChem 12 (5), 738-749, 2011 | 79 | 2011 |
| Acyclic nucleosides as antiviral compounds S Freeman, JM Gardiner Molecular biotechnology 5, 125-137, 1996 | 79 | 1996 |
| Structure-activity relationships of anti-HIV-1 N-alkoxy-and N-allyloxy-benzimidazoles TM Evans, JM Gardiner, N Mahmood, M Smis Bioorganic & Medicinal Chemistry Letters 7 (4), 409-412, 1997 | 73 | 1997 |
| Synthesis and HIV-1 inhibition of novel benzimidazole derivatives JM Gardiner, CR Loyns, A Burke, A Khan, N Mahmood Bioorganic & Medicinal Chemistry Letters 5 (12), 1251-1254, 1995 | 73 | 1995 |
| The influence of few-layer graphene on the gas permeability of the high-free-volume polymer PIM-1 K Althumayri, WJ Harrison, Y Shin, JM Gardiner, C Casiraghi, PM Budd, ... Philosophical Transactions of the Royal Society A: Mathematical, Physical …, 2016 | 72 | 2016 |
| Antibacterial activities of novel nicotinic acid hydrazides and their conversion into N-acetyl-1, 3, 4-oxadiazoles RY Morjan, AM Mkadmh, I Beadham, AA Elmanama, MR Mattar, J Raftery, ... Bioorganic & medicinal Chemistry letters 24 (24), 5796-5800, 2014 | 68 | 2014 |
| Focused directed evolution of pentaerythritol tetranitrate reductase by using automated anaerobic kinetic screening of site‐saturated libraries ME Hulley, HS Toogood, A Fryszkowska, D Mansell, GM Stephens, ... ChemBioChem 11 (17), 2433-2447, 2010 | 68 | 2010 |
| Biocatalytic Asymmetric Alkene Reduction: Crystal Structure and Characterization of a Double Bond Reductase from Nicotiana tabacum DJ Mansell, HS Toogood, J Waller, JMX Hughes, CW Levy, JM Gardiner, ... ACS catalysis 3 (3), 370-379, 2013 | 67 | 2013 |
| Structural basis of catalysis in the bacterial monoterpene synthases linalool synthase and 1, 8-cineole synthase V Karuppiah, KE Ranaghan, NGH Leferink, LO Johannissen, ... Acs Catalysis 7 (9), 6268-6282, 2017 | 66 | 2017 |
| Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis CL Cole, SU Hansen, M Barath, G Rushton, JM Gardiner, E Avizienyte, ... PLoS One 5 (7), e11644, 2010 | 64 | 2010 |
Nigel ScruttonProfessor of Enzymology, Manchester Institute of Biotechnology (MIB) and School of ChemistryE-mail confirmado em manchester.ac.uk
