Tuomas Knowles
Tuomas Knowles
Professor of Physical Chemistry and Biophysics, University of Cambridge
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The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo, CM Dobson
Nature reviews Molecular cell biology 15 (6), 384-396, 2014
Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism
SIA Cohen, S Linse, LM Luheshi, E Hellstrand, DA White, L Rajah, ...
Proceedings of the National Academy of Sciences 110 (24), 9758-9763, 2013
An analytical solution to the kinetics of breakable filament assembly
TPJ Knowles, CA Waudby, GL Devlin, SIA Cohen, A Aguzzi, ...
Science 326 (5959), 1533-1537, 2009
Direct observation of the interconversion of normal and toxic forms of α-synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ...
Cell 149 (5), 1048-1059, 2012
Role of intermolecular forces in defining material properties of protein nanofibrils
TP Knowles, AW Fitzpatrick, S Meehan, HR Mott, M Vendruscolo, ...
science 318 (5858), 1900-1903, 2007
Nanomechanics of functional and pathological amyloid materials
TPJ Knowles, MJ Buehler
Nature nanotechnology 6 (8), 469-479, 2011
On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse
Physical Chemistry Chemical Physics 17 (12), 7606-7618, 2015
FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-π interactions
S Qamar, GZ Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, ...
Cell 173 (3), 720-734. e15, 2018
Characterization of the nanoscale properties of individual amyloid fibrils
JF Smith, TPJ Knowles, CM Dobson, CE MacPhee, ME Welland
Proceedings of the National Academy of Sciences 103 (43), 15806-15811, 2006
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, ...
Proceedings of the National Academy of Sciences 111 (21), 7671-7676, 2014
Molecular mechanisms of protein aggregation from global fitting of kinetic models
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ...
Nature protocols 11 (2), 252-272, 2016
Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, ...
Nature chemical biology 11 (3), 229-234, 2015
Atomic structure and hierarchical assembly of a cross-β amyloid fibril
AWP Fitzpatrick, GT Debelouchina, MJ Bayro, DK Clare, MA Caporini, ...
Proceedings of the National Academy of Sciences 110 (14), 5468-5473, 2013
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015
From macroscopic measurements to microscopic mechanisms of protein aggregation
SIA Cohen, M Vendruscolo, CM Dobson, TPJ Knowles
Journal of molecular biology 421 (2-3), 160-171, 2012
Biomimetic peptide self-assembly for functional materials
A Levin, TA Hakala, L Schnaider, GJL Bernardes, E Gazit, TPJ Knowles
Nature Reviews Chemistry 4 (11), 615-634, 2020
Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
G Meisl, X Yang, E Hellstrand, B Frohm, JB Kirkegaard, SIA Cohen, ...
Proceedings of the National Academy of Sciences 111 (26), 9384-9389, 2014
Metastability of native proteins and the phenomenon of amyloid formation
AJ Baldwin, TPJ Knowles, GG Tartaglia, AW Fitzpatrick, GL Devlin, ...
Journal of the American Chemical Society 133 (36), 14160-14163, 2011
Amyloid fibrils as building blocks for natural and artificial functional materials
TPJ Knowles, R Mezzenga
Advanced materials 28 (31), 6546-6561, 2016
Half a century of amyloids: past, present and future
PC Ke, R Zhou, LC Serpell, R Riek, TPJ Knowles, HA Lashuel, E Gazit, ...
Chemical Society Reviews 49 (15), 5473-5509, 2020
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