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Talakad G. Lohith
Talakad G. Lohith
Associate Medical Director, Takeda
Email confirmado em takeda.com - Página inicial
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Preclinical characterization of 18F-MK-6240, a promising PET tracer for in vivo quantification of human neurofibrillary tangles
ED Hostetler, AM Walji, Z Zeng, P Miller, I Bennacef, C Salinas, ...
Journal of nuclear medicine 57 (10), 1599-1606, 2016
2452016
Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for …
AM Walji, ED Hostetler, H Selnick, Z Zeng, P Miller, I Bennacef, C Salinas, ...
Journal of medicinal chemistry 59 (10), 4778-4789, 2016
1692016
11C-ER176, a radioligand for 18-kDa translocator protein, has adequate sensitivity to robustly image all three affinity genotypes in human brain
M Ikawa, TG Lohith, S Shrestha, S Telu, SS Zoghbi, S Castellano, ...
Journal of Nuclear Medicine 58 (2), 320-325, 2017
1372017
Brain imaging of Alzheimer dementia patients and elderly controls with 18F-MK-6240, a PET tracer targeting neurofibrillary tangles
TG Lohith, I Bennacef, R Vandenberghe, M Vandenbulcke, CA Salinas, ...
Journal of Nuclear Medicine 60 (1), 107-114, 2019
1012019
Pathophysiologic correlation between 62Cu-ATSM and 18F-FDG in lung cancer
TG Lohith, T Kudo, Y Demura, Y Umeda, Y Kiyono, Y Fujibayashi, ...
Journal of Nuclear Medicine 50 (12), 1948-1953, 2009
872009
Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery
RW Pipal, KT Stout, PZ Musacchio, S Ren, TJA Graham, S Verhoog, ...
Nature 589 (7843), 542-547, 2021
702021
Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A
TG Lohith, SS Zoghbi, CL Morse, MF Araneta, VN Barth, NA Goebl, ...
Journal of Nuclear Medicine 53 (3), 385-392, 2012
702012
Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?
TG Lohith, EK Osterweil, M Fujita, KJ Jenko, MF Bear, RB Innis
Molecular autism 4, 1-8, 2013
632013
Guidelines for the content and format of PET brain data in publications and archives: a consensus paper
GM Knudsen, M Ganz, S Appelhoff, R Boellaard, G Bormans, RE Carson, ...
Journal of Cerebral Blood Flow & Metabolism 40 (8), 1576-1585, 2020
582020
Brain and whole-body imaging in rhesus monkeys of 11C-NOP-1A, a promising PET radioligand for nociceptin/orphanin FQ peptide receptors
Y Kimura, M Fujita, J Hong, TG Lohith, RL Gladding, SS Zoghbi, ...
Journal of Nuclear Medicine 52 (10), 1638-1645, 2011
492011
Potential of the FES–hERL PET reporter gene system—Basic evaluation for gene therapy monitoring
T Furukawa, TG Lohith, S Takamatsu, T Mori, T Tanaka, Y Fujibayashi
Nuclear medicine and biology 33 (1), 145-151, 2006
362006
Development of microwave-based automated nucleophilic [18F] fluorination system and its application to the production of [18F] flumazenil
KS Mandap, T Ido, Y Kiyono, M Kobayashi, TG Lohith, T Mori, ...
Nuclear medicine and biology 36 (4), 403-409, 2009
312009
Retest imaging of [11C] NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans
TG Lohith, SS Zoghbi, CL Morse, MDF Araneta, VN Barth, NA Goebl, ...
Neuroimage 87, 89-95, 2014
292014
Comparison of two PET radioligands, [11C]FPEB and [11C]SP203, for quantification of metabotropic glutamate receptor 5 in human brain
TG Lohith, T Tsujikawa, FG Siméon, M Veronese, SS Zoghbi, CH Lyoo, ...
Journal of Cerebral Blood Flow & Metabolism 37 (7), 2458-2470, 2017
262017
Evaluation of Novel N1-Methyl-2-phenylindol-3-ylglyoxylamides as a New Chemotype of 18 kDa Translocator Protein-Selective Ligand Suitable for the …
VW Pike, S Taliani, TG Lohith, DRJ Owen, I Pugliesi, E Da Pozzo, J Hong, ...
Journal of medicinal chemistry 54 (1), 366-373, 2011
252011
Preclinical Safety Evaluation and Human Dosimetry of [18F]MK-6240, a Novel PET Tracer for Imaging Neurofibrillary Tangles
M Koole, TG Lohith, JL Valentine, I Bennacef, R Declercq, T Reynders, ...
Molecular imaging and biology 22, 173-180, 2020
242020
Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease
C Salinas, TG Lohith, A Purohit, A Struyk, C Sur, I Bennacef, J Beaver, ...
Journal of Cerebral Blood Flow & Metabolism 40 (11), 2179-2187, 2020
232020
Improved models for plasma radiometabolite correction and their impact on kinetic quantification in PET studies
M Tonietto, M Veronese, G Rizzo, P Zanotti-Fregonara, TG Lohith, ...
Journal of Cerebral Blood Flow & Metabolism 35 (9), 1462-1469, 2015
192015
Basic Evaluation of FES-hERL PET Tracer-Reporter Gene System for In Vivo Monitoring of Adenoviral-Mediated Gene Therapy
TG Lohith, T Furukawa, T Mori, M Kobayashi, Y Fujibayashi
Molecular Imaging and Biology 10, 245-252, 2008
182008
Biomarkers consortium Radioligand project T. 11C-ER176, a Radioligand for 18-kDa Translocator protein, has adequate sensitivity to robustly image all three affinity genotypes …
M Ikawa, TG Lohith, S Shrestha, S Telu, SS Zoghbi, S Castellano, ...
J Nucl Med 58 (2), 320-325, 2017
162017
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