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Carlos Alberto Manssour Fraga
Carlos Alberto Manssour Fraga
Professor de Farmacologia e Química Medicinal, Universidade Federal do Rio de Janeiro
E-mail confirmado em ccsdecania.ufrj.br
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Molecular hybridization: a useful tool in the design of new drug prototypes
C Viegas-Junior, A Danuello, V da Silva Bolzani, EJ Barreiro, CAM Fraga
Current medicinal chemistry 14 (17), 1829-1852, 2007
12092007
The methylation effect in medicinal chemistry
EJ Barreiro, AE Kümmerle, CAM Fraga
Chemical reviews 111 (9), 5215-5246, 2011
7772011
From nature to drug discovery: the indole scaffold as a ‘privileged structure’
FR de Sa Alves, EJ Barreiro, CA Manssour Fraga
Mini reviews in medicinal chemistry 9 (7), 782-793, 2009
6232009
Synthesis and analgesic activity of novel N-acylarylhydrazones and isosters, derived from natural safrole
PC Lima, LM Lima, KCM da Silva, PHO Léda, ALP de Miranda, ...
European journal of medicinal chemistry 35 (2), 187-203, 2000
3312000
Synthesis and anti-inflammatory activity of phthalimide derivatives, designed as new thalidomide analogues
LM Lima, P Castro, AL Machado, CAM Fraga, C Lugnier, VLG De Moraes, ...
Bioorganic & medicinal chemistry 10 (9), 3067-3073, 2002
2632002
Discovery of novel analgesic and anti-inflammatory 3-arylamine-imidazo [1, 2-a] pyridine symbiotic prototypes
RB Lacerda, CKF de Lima, LL da Silva, NC Romeiro, ALP Miranda, ...
Bioorganic & medicinal chemistry 17 (1), 74-84, 2009
2312009
New class of potent antinociceptive and antiplatelet 10H-phenothiazine-1-acylhydrazone derivatives
GA Silva, LMM Costa, FCF Brito, ALP Miranda, EJ Barreiro, CAM Fraga
Bioorganic & medicinal chemistry 12 (12), 3149-3158, 2004
2042004
Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer
C Viegas Junior, VS Bolzani, M Furlan, CAM Fraga, EJ Barreiro
Química Nova 27, 655-660, 2004
1802004
N-Acylhydrazones as drugs
S Thota, DA Rodrigues, PSM Pinheiro, LM Lima, CAM Fraga, EJ Barreiro
Bioorganic & medicinal chemistry letters 28 (17), 2797-2806, 2018
1712018
Design, Synthesis, and Pharmacological Profile of Novel Fused Pyrazolo[4,3-d]pyridine and Pyrazolo[3,4-b][1,8]naphthyridine Isosteres:  A New Class of Potent …
EJ Barreiro, CA Camara, H Verli, L Brazil-Más, NG Castro, WM Cintra, ...
Journal of medicinal chemistry 46 (7), 1144-1152, 2003
1452003
Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues
AG Silva, G Zapata-Sudo, AE Kummerle, CAM Fraga, EJ Barreiro, ...
Bioorganic & medicinal chemistry 13 (10), 3431-3437, 2005
1392005
Medicinal chemistry of N-acylhydrazones: new lead-compounds of analgesic, antiinflammatory and antithrombotic drugs
CAM Fraga, EJ Barreiro
Current medicinal chemistry 13 (2), 167-198, 2006
1322006
The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders II: Alzheimer's disease
M Divino da Rocha, F Pereira Dias Viegas, H Cristina Campos, ...
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …, 2011
1282011
Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors
DA Rodrigues, GA Ferreira-Silva, ACS Ferreira, RA Fernandes, JK Kwee, ...
Journal of medicinal chemistry 59 (2), 655-670, 2016
1152016
Design, Synthesis, and Pharmacological Evaluation of N-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally …
AE Kümmerle, M Schmitt, SVS Cardozo, C Lugnier, P Villa, AB Lopes, ...
Journal of medicinal chemistry 55 (17), 7525-7545, 2012
1142012
Design, synthesis and pharmacological profile of novel dopamine D2 receptor ligands
R Menegatti, AC Cunha, VF Ferreira, EFR Perreira, A El-Nabawi, ...
Bioorganic & medicinal chemistry 11 (22), 4807-4813, 2003
1122003
Synthesis and antitrypanosomal profile of new functionalized 1, 3, 4-thiadiazole-2-arylhydrazone derivatives, designed as non-mutagenic megazol analogues
SA Carvalho, EF da Silva, RM Santa-Rita, SL de Castro, CAM Fraga
Bioorganic & medicinal chemistry letters 14 (24), 5967-5970, 2004
1112004
Characterization of Amide Bond Conformers for a Novel Heterocyclic Template of N-acylhydrazone Derivatives
AB Lopes, E Miguez, AE Kümmerle, VM Rumjanek, CAM Fraga, ...
Molecules 18 (10), 11683-11704, 2013
1102013
Design and synthesis of 3, 4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: new lead-agents with analgesic and antipyretic properties
HJC Bezerra-Netto, DI Lacerda, ALP Miranda, HM Alves, EJ Barreiro, ...
Bioorganic & medicinal chemistry 14 (23), 7924-7935, 2006
1072006
Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide
AL Machado, LM Lima, JX Araújo-Jr, CAM Fraga, VLG Koatz, EJ Barreiro
Bioorganic & Medicinal Chemistry Letters 15 (4), 1169-1172, 2005
1042005
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