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Richard I. Morimoto
Richard I. Morimoto
Bill and Gayle Cook Professor of Biology, Dept of Molecular Biosciences, Northwestern
E-mail confirmado em northwestern.edu - Página inicial
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Adapting proteostasis for disease intervention
WE Balch, RI Morimoto, A Dillin, JW Kelly
science 319 (5865), 916-919, 2008
23402008
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators
RI Morimoto
Genes & development 12 (24), 3788-3796, 1998
22701998
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
HM Beere, BB Wolf, K Cain, DD Mosser, A Mahboubi, T Kuwana, P Tailor, ...
Nature cell biology 2 (8), 469-475, 2000
18742000
Cells in stress: transcriptional activation of heat shock genes
RI Morimoto
Science 259 (5100), 1409-1410, 1993
17891993
Geroscience: linking aging to chronic disease
BK Kennedy, SL Berger, A Brunet, J Campisi, AM Cuervo, ES Epel, ...
Cell 159 (4), 709-713, 2014
14312014
Heat shock factors: integrators of cell stress, development and lifespan
M Åkerfelt, RI Morimoto, L Sistonen
Nature reviews Molecular cell biology 11 (8), 545-555, 2010
14002010
Role of the heat shock response and molecular chaperones in oncogenesis and cell death
C Jolly, RI Morimoto
Journal of the National Cancer Institute 92 (19), 1564-1572, 2000
13282000
Biological and chemical approaches to diseases of proteostasis deficiency
ET Powers, RI Morimoto, A Dillin, JW Kelly, WE Balch
Annual review of biochemistry 78 (1), 959-991, 2009
12692009
The biology of heat shock proteins and molecular chaperones
RI Morimoto, A Tissières
1258*1994
Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the …
KD Sarge, SP Murphy, RI Morimoto
Molecular and cellular biology 13 (3), 1392-1407, 1993
10971993
Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.
C Hunt, RI Morimoto
Proceedings of the National Academy of Sciences 82 (19), 6455-6459, 1985
10771985
The biology of proteostasis in aging and disease
J Labbadia, RI Morimoto
Annual review of biochemistry 84, 435, 2015
10192015
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
RI Morimoto
Genes & development 22 (11), 1427-1438, 2008
9822008
The chaperone function of hsp70 is required for protection against stress-induced apoptosis
DD Mosser, AW Caron, L Bourget, AB Meriin, MY Sherman, RI Morimoto, ...
Molecular and cellular biology 20 (19), 7146-7159, 2000
9012000
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
JF Morley, HR Brignull, JJ Weyers, RI Morimoto
Proceedings of the National Academy of Sciences 99 (16), 10417-10422, 2002
8512002
Chaperoning signaling pathways: molecular chaperones as stress-sensingheat shock'proteins
EAA Nollen, RI Morimoto
Journal of cell science 115 (14), 2809-2816, 2002
8072002
Regulation of Longevity in Caenorhabditis elegans by Heat Shock Factor and Molecular Chaperones
JF Morley, RI Morimoto
Molecular biology of the cell 15 (2), 657-664, 2004
8052004
Molecularchaperones as HSF1-specific transcriptional repressors
Y Shi, DD Mosser, RI Morimoto
Genes & development 12 (5), 654-666, 1998
7731998
Stress–inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection
RI Morimoto, MG Santoro
Nature biotechnology 16 (9), 833-838, 1998
7581998
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
SD Westerheide, J Anckar, SM Stevens Jr, L Sistonen, RI Morimoto
Science 323 (5917), 1063-1066, 2009
7522009
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Artigos 1–20