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Alejandro Chavez
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Year
Age-related clonal hematopoiesis associated with adverse outcomes
S Jaiswal, P Fontanillas, J Flannick, A Manning, PV Grauman, BG Mar, ...
New England Journal of Medicine 371 (26), 2488-2498, 2014
43902014
Highly efficient Cas9-mediated transcriptional programming
A Chavez, J Scheiman, S Vora, BW Pruitt, M Tuttle, E PR Iyer, S Lin, ...
Nature methods 12 (4), 326-328, 2015
15872015
Comparison of Cas9 activators in multiple species
A Chavez, M Tuttle, BW Pruitt, B Ewen-Campen, R Chari, ...
Nature methods 13 (7), 563-567, 2016
5532016
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation
EAA Nollen, SM Garcia, G Van Haaften, S Kim, A Chavez, RI Morimoto, ...
Proceedings of the National Academy of Sciences of the United States of …, 2004
5102004
Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform
JM Rock, FF Hopkins, A Chavez, M Diallo, MR Chase, ER Gerrick, ...
Nature microbiology 2 (4), 1-9, 2017
4552017
A critical role for TCF-1 in T-lineage specification and differentiation
BN Weber, AWS Chi, A Chavez, Y Yashiro-Ohtani, Q Yang, O Shestova, ...
Nature 476 (7358), 63-68, 2011
4472011
An enhanced CRISPR repressor for targeted mammalian gene regulation
NC Yeo, A Chavez, A Lance-Byrne, Y Chan, D Menn, D Milanova, ...
Nature methods 15 (8), 611-616, 2018
4392018
Safeguarding CRISPR-Cas9 gene drives in yeast
JE DiCarlo, A Chavez, SL Dietz, KM Esvelt, GM Church
Nature biotechnology 33 (12), 1250-1255, 2015
3852015
Cas9 gRNA engineering for genome editing, activation and repression
S Kiani, A Chavez, M Tuttle, RN Hall, R Chari, D Ter-Ovanesyan, J Qian, ...
Nature methods 12 (11), 1051-1054, 2015
3532015
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance
AC Bester, JD Lee, A Chavez, YR Lee, D Nachmani, S Vora, J Victor, ...
Cell 173 (3), 649-664. e20, 2018
2932018
Daisy-chain gene drives for the alteration of local populations
C Noble, J Min, J Olejarz, J Buchthal, A Chavez, AL Smidler, ...
Proceedings of the National Academy of Sciences 116 (17), 8275-8282, 2019
2382019
sgRNA Scorer 2.0: A species-independent model to predict CRISPR/Cas9 activity
R Chari, NC Yeo, A Chavez, GM Church
ACS synthetic biology 6 (5), 902-904, 2017
2222017
Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir
S Iketani, H Mohri, B Culbertson, SJ Hong, Y Duan, MI Luck, ...
Nature 613 (7944), 558-564, 2023
2092023
A CRISPR–Cas9-based gene drive platform for genetic interaction analysis in Candida albicans
RS Shapiro, A Chavez, CBM Porter, M Hamblin, CS Kaas, JE DiCarlo, ...
Nature microbiology 3 (1), 73-82, 2018
1512018
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks
R Clarke, R Heler, MS MacDougall, NC Yeo, A Chavez, M Regan, ...
Molecular cell 71 (1), 42-55. e8, 2018
1422018
Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors
S Iketani, F Forouhar, H Liu, SJ Hong, FY Lin, MS Nair, A Zask, Y Huang, ...
Nature communications 12 (1), 2016, 2021
1002021
CRISPR-based genomic tools for the manipulation of genetically intractable microorganisms
RS Shapiro, A Chavez, JJ Collins
Nature Reviews Microbiology 16 (6), 333-339, 2018
972018
Rap1 relocalization contributes to the chromatin-mediated gene expression profile and pace of cell senescence
JM Platt, P Ryvkin, JJ Wanat, G Donahue, MD Ricketts, SP Barrett, ...
Genes & development 27 (12), 1406-1420, 2013
962013
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast
X Guo, A Chavez, A Tung, Y Chan, C Kaas, Y Yin, R Cecchi, SL Garnier, ...
Nature biotechnology 36 (6), 540-546, 2018
922018
Sumoylation and the structural maintenance of chromosomes (Smc) 5/6 complex slow senescence through recombination intermediate resolution
A Chavez, V George, V Agrawal, FB Johnson
Journal of Biological Chemistry 285 (16), 11922-11930, 2010
762010
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Articles 1–20