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Yun Li
Yun Li
Principal Investigator, the Hospital for Sick Children. Assistant Professor, University of Toronto
E-mail confirmado em sickkids.ca
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TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment
Y Li, BW Luikart, S Birnbaum, J Chen, CH Kwon, SG Kernie, ...
Neuron 59 (3), 399-412, 2008
7262008
Efficient derivation of microglia-like cells from human pluripotent stem cells
J Muffat, Y Li, B Yuan, M Mitalipova, A Omer, S Corcoran, G Bakiasi, ...
Nature medicine 22 (11), 1358-1367, 2016
5992016
Rescue of fragile X syndrome neurons by DNA methylation editing of the FMR1 gene
XS Liu, H Wu, M Krzisch, X Wu, J Graef, J Muffat, D Hnisz, CH Li, B Yuan, ...
Cell 172 (5), 979-992. e6, 2018
4542018
Induction of expansion and folding in human cerebral organoids
Y Li, J Muffat, A Omer, I Bosch, MA Lancaster, M Sur, L Gehrke, ...
Cell stem cell 20 (3), 385-396. e3, 2017
3992017
Global transcriptional and translational repression in human-embryonic-stem-cell-derived Rett syndrome neurons
Y Li, H Wang, J Muffat, AW Cheng, DA Orlando, J Lovén, S Kwok, ...
Cell stem cell 13 (4), 446-458, 2013
3452013
MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling
N Mellios, DA Feldman, SD Sheridan, JPK Ip, S Kwok, SK Amoah, ...
Molecular psychiatry 23 (4), 1051-1065, 2018
2342018
miR-132 mediates the integration of newborn neurons into the adult dentate gyrus
BW Luikart, ASL Bensen, EK Washburn, JV Perederiy, KG Su, Y Li, ...
PloS one 6 (5), e19077, 2011
1842011
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF
SH Choi, Y Li, LF Parada, SS Sisodia
Molecular neurodegeneration 4, 1-12, 2009
1312009
Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections
J Muffat, Y Li, A Omer, A Durbin, I Bosch, G Bakiasi, E Richards, A Meyer, ...
Proceedings of the National Academy of Sciences 115 (27), 7117-7122, 2018
1192018
Genome-wide CRISPR screen for Zika virus resistance in human neural cells
Y Li, J Muffat, A Omer Javed, HR Keys, T Lungjangwa, I Bosch, M Khan, ...
Proceedings of the National Academy of Sciences 116 (19), 9527-9532, 2019
1002019
Conditional ablation of brain-derived neurotrophic factor-TrkB signaling impairs striatal neuron development
Y Li, D Yui, BW Luikart, RM McKay, Y Li, JL Rubenstein, LF Parada
Proceedings of the National Academy of Sciences, 2012
932012
TrkA Gene Ablation in Basal Forebrain Results in Dysfunction of the Cholinergic Circuitry
E Sanchez-Ortiz, D Yui, D Song, Y Li, JL Rubenstein, LF Reichardt, ...
The Journal of Neuroscience 32 (12), 4065-4079, 2012
922012
Neurofibromin is required for barrel formation in the mouse somatosensory cortex
ME Lush, Y Li, CH Kwon, J Chen, LF Parada
The Journal of Neuroscience 28 (7), 1580-1587, 2008
522008
Studying human neurodevelopment and diseases using 3D brain organoids
A Tian, J Muffat, Y Li
Journal of Neuroscience 40 (6), 1186-1193, 2020
502020
Microcephaly modeling of kinetochore mutation reveals a brain-specific phenotype
AO Javed, Y Li, J Muffat, KC Su, MA Cohen, T Lungjangwa, P Aubourg, ...
Cell reports 25 (2), 368-382. e5, 2018
392018
Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants
Y Li, Y Li, RM McKay, D Riethmacher, LF Parada
Journal of Neuroscience 32 (10), 3529-3539, 2012
362012
CNS disease models with human pluripotent stem cells in the CRISPR age
J Muffat, Y Li, R Jaenisch
Current opinion in cell biology 43, 96-103, 2016
262016
Modeling developmental brain diseases using human pluripotent stem cells-derived brain organoids–progress and perspective
A Bhattacharya, WWY Choi, J Muffat, Y Li
Journal of Molecular Biology 434 (3), 167386, 2022
202022
Modeling PTEN overexpression-induced microcephaly in human brain organoids
N Dhaliwal, WWY Choi, J Muffat, Y Li
Molecular Brain 14, 1-4, 2021
172021
Universal, label-free, single-molecule visualization of DNA origami nanodevices across biological samples using origamiFISH
WX Wang, TR Douglas, H Zhang, A Bhattacharya, M Rothenbroker, ...
Nature Nanotechnology 19 (1), 58-69, 2024
52024
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