| Metagenome mining reveals polytheonamides as posttranslationally modified ribosomal peptides MF Freeman, C Gurgui, MJ Helf, BI Morinaka, AR Uria, NJ Oldham, ... Science 338 (6105), 387-390, 2012 | 386 | 2012 |
| Radical S‐Adenosyl Methionine Epimerases: Regioselective Introduction of Diverse D‐Amino Acid Patterns into Peptide Natural Products BI Morinaka, AL Vagstad, MJ Helf, M Gugger, C Kegler, MF Freeman, ... Angewandte Chemie International Edition 53 (32), 8503-8507, 2014 | 127 | 2014 |
| Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium MF Freeman, MJ Helf, A Bhushan, BI Morinaka, J Piel Nature chemistry 9 (4), 387-395, 2017 | 124 | 2017 |
| Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products NS Van Der Velden, N Kälin, MJ Helf, J Piel, MF Freeman, M Künzler Nature chemical biology 13 (8), 833-835, 2017 | 119 | 2017 |
| A multiproducer microbiome generates chemical diversity in the marine sponge Mycale hentscheli M Rust, EJN Helfrich, MF Freeman, P Nanudorn, CM Field, C Rückert, ... Proceedings of the National Academy of Sciences 117 (17), 9508-9518, 2020 | 83 | 2020 |
| Genome mining-and synthetic biology-enabled production of hypermodified peptides A Bhushan, PJ Egli, EE Peters, MF Freeman, J Piel Nature chemistry 11 (10), 931-939, 2019 | 61 | 2019 |
| Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’bacteria MF Freeman, AL Vagstad, J Piel Current opinion in chemical biology 31, 8-14, 2016 | 60 | 2016 |
| Distinct Autocatalytic α-N-Methylating Precursors Expand the Borosin RiPP Family of Peptide Natural Products MR Quijano, C Zach, FS Miller, AR Lee, AS Imani, M Künzler, ... Journal of the American Chemical Society 141 (24), 9637-9644, 2019 | 50 | 2019 |
| A molecular mechanism for the enzymatic methylation of nitrogen atoms within peptide bonds H Song, NS Van Der Velden, SL Shiran, P Bleiziffer, C Zach, R Sieber, ... Science advances 4 (8), eaat2720, 2018 | 50 | 2018 |
| Dissection of the stepwise mechanism to β-lactam formation and elucidation of a rate-determining conformational change in β-lactam synthetase ML Raber, MF Freeman, CA Townsend Journal of biological chemistry 284 (1), 207-217, 2009 | 41 | 2009 |
| An Orthogonal D2O‐Based Induction System that Provides Insights into d‐Amino Acid Pattern Formation by Radical S‐Adenosylmethionine Peptide Epimerases BI Morinaka, M Verest, MF Freeman, M Gugger, J Piel Angewandte Chemie 129 (3), 780-784, 2017 | 39 | 2017 |
| Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis MF Freeman, KA Moshos, MJ Bodner, R Li, CA Townsend Proceedings of the National Academy of Sciences 105 (32), 11128-11133, 2008 | 39 | 2008 |
| Definition of the Common and Divergent Steps in Carbapenem β‐Lactam Antibiotic Biosynthesis MJ Bodner, R Li, RM Phelan, MF Freeman, KA Moshos, EP Lloyd, ... ChemBioChem 12 (14), 2159-2165, 2011 | 37 | 2011 |
| Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics MJ Bodner, RM Phelan, MF Freeman, R Li, CA Townsend Journal of the American Chemical Society 132 (1), 12-13, 2010 | 35 | 2010 |
| The catalytic diversity of multimodular polyketide synthases: natural product biosynthesis beyond textbook assembly rules TAM Gulder, MF Freeman, J Piel | 33 | 2011 |
| Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis X Cai, R Teta, C Kohlhaas, M Crüsemann, R Ueoka, A Mangoni, ... Chemistry & Biology 20 (6), 839-846, 2013 | 27 | 2013 |
| Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis FS Miller, KK Crone, MR Jensen, S Shaw, WR Harcombe, MH Elias, ... Nature Communications 12 (1), 5355, 2021 | 26 | 2021 |
| Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement AR Buller, MF Freeman, NT Wright, JF Schildbach, CA Townsend Proceedings of the National Academy of Sciences 109 (7), 2308-2313, 2012 | 24 | 2012 |
| Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis MJ Helf, MF Freeman, J Piel Journal of Industrial Microbiology and Biotechnology 46 (3-4), 551-563, 2019 | 14 | 2019 |
| Diverse Protein Architectures and α-N-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters AS Imani, AR Lee, N Vishwanathan, F De Waal, MF Freeman ACS chemical biology 17 (4), 908-917, 2022 | 11 | 2022 |
