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bart staker
bart staker
Center for Infectious Disease Research
E-mail confirmado em cidresearch.org - Página inicial
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The mechanism of topoisomerase I poisoning by a camptothecin analog
BL Staker, K Hjerrild, MD Feese, CA Behnke, AB Burgin Jr, L Stewart
Proceedings of the National Academy of Sciences 99 (24), 15387-15392, 2002
9562002
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis
P Towler, B Staker, SG Prasad, S Menon, J Tang, T Parsons, D Ryan, ...
Journal of Biological Chemistry 279 (17), 17996-18007, 2004
7672004
Structures of three classes of anticancer agents bound to the human topoisomerase I− DNA covalent complex
BL Staker, MD Feese, M Cushman, Y Pommier, D Zembower, L Stewart, ...
Journal of medicinal chemistry 48 (7), 2336-2345, 2005
5772005
Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
AB Burgin, OT Magnusson, J Singh, P Witte, BL Staker, JM Bjornsson, ...
Nature biotechnology 28 (1), 63-70, 2010
4112010
Specific Btk inhibition suppresses B cell–and myeloid cell–mediated arthritis
JA Di Paolo, T Huang, M Balazs, J Barbosa, KH Barck, BJ Bravo, ...
Nature chemical biology 7 (1), 41-50, 2011
3782011
Biological and structural characterization of a host-adapting amino acid in influenza virus
S Yamada, M Hatta, BL Staker, S Watanabe, M Imai, K Shinya, ...
PLoS pathogens 6 (8), e1001034, 2010
3522010
RNA methylation under heat shock control
H Bügl, EB Fauman, BL Staker, F Zheng, SR Kushner, MA Saper, ...
Molecular cell 6 (2), 349-360, 2000
2932000
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex
C Marchand, S Antony, KW Kohn, M Cushman, A Ioanoviciu, BL Staker, ...
Molecular cancer therapeutics 5 (2), 287-295, 2006
1872006
Mechanisms of camptothecin resistance by human topoisomerase I mutations
JE Chrencik, BL Staker, AB Burgin, P Pourquier, Y Pommier, L Stewart, ...
Journal of molecular biology 339 (4), 773-784, 2004
1822004
DcpS as a therapeutic target for spinal muscular atrophy
J Singh, M Salcius, SW Liu, BL Staker, R Mishra, J Thurmond, G Michaud, ...
ACS chemical biology 3 (11), 711-722, 2008
1422008
Combining functional and structural genomics to sample the essential Burkholderia structome
L Baugh, LA Gallagher, R Patrapuvich, MC Clifton, AS Gardberg, ...
PloS one 8 (1), e53851, 2013
1392013
Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA− enzyme …
A Ioanoviciu, S Antony, Y Pommier, BL Staker, L Stewart, M Cushman
Journal of medicinal chemistry 48 (15), 4803-4814, 2005
1292005
Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline− camptothecin hybrids
BM Fox, X Xiao, S Antony, G Kohlhagen, Y Pommier, BL Staker, L Stewart, ...
Journal of medicinal chemistry 46 (15), 3275-3282, 2003
1272003
Increasing the structural coverage of tuberculosis drug targets
L Baugh, I Phan, DW Begley, MC Clifton, B Armour, DM Dranow, ...
Tuberculosis 95 (2), 142-148, 2015
1192015
Active site in RrmJ, a heat shock-induced methyltransferase
J Hager, BL Staker, H Bugl, U Jakob
Journal of Biological Chemistry 277 (44), 41978-41986, 2002
1132002
The seattle structural genomics center for infectious disease (SSGCID)
PJ Myler, R Stacy, L Stewart, BL Staker, WC Van Voorhis, G Varani, ...
Infectious Disorders-Drug Targets (Formerly Current Drug Targets-Infectious …, 2009
1062009
The plug-based nanovolume microcapillary protein crystallization system (MPCS)
CJ Gerdts, M Elliott, S Lovell, MB Mixon, AJ Napuli, BL Staker, P Nollert, ...
Acta Crystallographica Section D: Biological Crystallography 64 (11), 1116-1122, 2008
822008
SAD phasing using iodide ions in a high-throughput structural genomics environment
J Abendroth, AS Gardberg, JI Robinson, JS Christensen, BL Staker, ...
Journal of structural and functional genomics 12, 83-95, 2011
792011
Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues
AC Raymond, MC Rideout, B Staker, K Hjerrild, AB Burgin Jr
Journal of molecular biology 338 (5), 895-906, 2004
752004
Structure of Hsp15 reveals a novel RNA‐binding motif
BL Staker, P Korber, JCA Bardwell, MA Saper
The EMBO journal, 2000
672000
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