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Carlos Escande
Carlos Escande
Principal Investigator, Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo
E-mail confirmado em pasteur.edu.uy
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CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism
J Camacho-Pereira, MG Tarragó, CCS Chini, V Nin, C Escande, ...
Cell metabolism 23 (6), 1127-1139, 2016
7952016
Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome
C Escande, V Nin, NL Price, V Capellini, AP Gomes, MT Barbosa, ...
Diabetes 62 (4), 1084-1093, 2013
3732013
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
C Escande, CCS Chini, V Nin, KM Dykhouse, CM Novak, J Levine, ...
The Journal of clinical investigation 120 (2), 545-558, 2010
2182010
Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38
P Aksoy, C Escande, TA White, M Thompson, S Soares, JC Benech, ...
Biochemical and biophysical research communications 349 (1), 353-359, 2006
2132006
Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors
CCS Chini, AMG Guerrico, V Nin, J Camacho-Pereira, C Escande, ...
Clinical cancer research 20 (1), 120-130, 2014
1502014
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase
V Nin, C Escande, CC Chini, S Giri, J Camacho-Pereira, J Matalonga, ...
Journal of Biological Chemistry 287 (28), 23489-23501, 2012
1362012
Potential modulation of sirtuins by oxidative stress
L Santos, C Escande, A Denicola
Oxidative medicine and cellular longevity 2016 (1), 9831825, 2016
1232016
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice
MB Stout, T Tchkonia, T Pirtskhalava, AK Palmer, EO List, DE Berryman, ...
Aging (Albany NY) 6 (7), 575, 2014
1222014
The nuclear receptor LXR limits bacterial infection of host macrophages through a mechanism that impacts cellular NAD metabolism
J Matalonga, E Glaria, M Bresque, C Escande, JM Carbó, K Kiefer, ...
Cell reports 18 (5), 1241-1255, 2017
1122017
Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity
CM Novak, C Escande, PR Burghardt, M Zhang, MT Barbosa, EN Chini, ...
Hormones and behavior 58 (3), 355-367, 2010
1122010
HDAC3 is negatively regulated by the nuclear protein DBC1
CCS Chini, C Escande, V Nin, EN Chini
Journal of Biological Chemistry 285 (52), 40830-40837, 2010
1042010
Endurance capacity, not body size, determines physical activity levels: role of skeletal muscle PEPCK
CM Novak, C Escande, SM Gerber, EN Chini, M Zhang, SL Britton, ...
PloS one 4 (6), e5869, 2009
692009
Early and late calcium waves during wound healing in corneal endothelial cells
S Chifflet, C Justet, JA Hernández, V Nin, C Escande, JC Benech
Wound Repair and Regeneration 20 (1), 28-37, 2012
512012
Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer
EN Chini, CCS Chini, V Nin, C Escande
Bioscience reports 33 (4), e00058, 2013
482013
Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes …
G Lomberk, A Grzenda, A Mathison, C Escande, JS Zhang, E Calvo, ...
Journal of Biological Chemistry 288 (24), 17745-17758, 2013
482013
DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα
CCS Chini, C Escande, V Nin, EN Chini
Biochemical Journal 451 (3), 453-461, 2013
482013
CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system
WR Hartman, LL Pelleymounter, I Moon, K Kalari, M Liu, TY Wu, ...
Leukemia & lymphoma 51 (7), 1315-1325, 2010
432010
SIRT1-activating compounds (STAC) negatively regulate pancreatic cancer cell growth and viability through a SIRT1 lysosomal-dependent pathway
CCS Chini, JM Espindola-Netto, G Mondal, AMG Guerrico, V Nin, ...
Clinical Cancer Research 22 (10), 2496-2507, 2016
392016
Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells
J Martínez, D Tarallo, L Martínez-Palma, S Victoria, M Bresque, ...
Biochemical Journal 476 (17), 2463-2486, 2019
362019
Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype
C Escande, V Nin, T Pirtskhalava, CCS Chini, T Tchkonia, JL Kirkland, ...
Diabetes 64 (1), 12-22, 2015
342015
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