|A new view into the regulation of purine metabolism: the purinosome|
AM Pedley, SJ Benkovic
Trends in biochemical sciences 42 (2), 141-154, 2017
|Spatial colocalization and functional link of purinosomes with mitochondria|
JB French, SA Jones, H Deng, AM Pedley, D Kim, CY Chan, H Hu, ...
Science 351 (6274), 733-737, 2016
|Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis|
H Zhao, CR Chiaro, L Zhang, PB Smith, CY Chan, AM Pedley, RJ Pugh, ...
Journal of Biological Chemistry 290 (11), 6705-6713, 2015
|Purinosome formation as a function of the cell cycle|
CY Chan, H Zhao, RJ Pugh, AM Pedley, J French, SA Jones, X Zhuang, ...
Proceedings of the National Academy of Sciences 112 (5), 1368-1373, 2015
|Flexibility of PCNA-protein interface accommodates differential binding partners|
AM Pedley, MA Lill, VJ Davisson
PLoS One 9 (7), e102481, 2014
|Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase|
JC Oliver, R Gudihal, JW Burgner, AM Pedley, AT Zwierko, VJ Davisson, ...
Archives of biochemistry and biophysics 545, 22-32, 2014
|Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria|
CY Chan, AM Pedley, D Kim, C Xia, X Zhuang, SJ Benkovic
Proceedings of the National Academy of Sciences 115 (51), 13009-13014, 2018
|Replication protein A dynamically regulates monoubiquitination of proliferating cell nuclear antigen|
M Hedglin, M Aitha, A Pedley, SJ Benkovic
Journal of Biological Chemistry 294 (13), 5157-5168, 2019
|Selective inhibition of STAT3 phosphorylation using a nuclear-targeted kinase inhibitor|
MD Bartolowits, W Brown, R Ali, AM Pedley, Q Chen, KE Harvey, ...
ACS chemical biology 12 (9), 2371-2378, 2017
|Role of HSP90 in the Regulation of de Novo Purine Biosynthesis|
AM Pedley, GI Karras, X Zhang, S Lindquist, SJ Benkovic
Biochemistry 57 (23), 3217-3221, 2018
|Identification of FAK substrate peptides via colorimetric screening of a one‐bead one‐peptide combinatorial library|
LA Witucki, LS Borowicz, AM Pedley, J Curtis‐Fisk, EG Kuszpit
Journal of Peptide Science 21 (4), 302-311, 2015
|Mapping post-translational modifications of de novo purine biosynthetic enzymes: implications for pathway regulation|
C Liu, GM Knudsen, AM Pedley, J He, JL Johnson, TM Yaron, LC Cantley, ...
Journal of proteome research 18 (5), 2078-2087, 2019
|Detecting purinosome metabolon formation with fluorescence microscopy|
AM Pedley, SJ Benkovic
Protein Complex Assembly, 279-289, 2018
|Hypoxia Drives the Assembly of the Multi-Enzyme Purinosome Complex|
C Doigneaux, AM Pedley, IN Mistry, M Papayova, SJ Benkovic, ...
Journal of Biological Chemistry, jbc. RA119. 012175, 2020
|Dataset for: Hypoxia drives the assembly of the multi-enzyme purinosome complex|
C Doigneaux, A Pedley, IN Mistry, M Papayova, S Benkovic, A Tavassoli
University of Southampton, 2020
|Observations on the Cellular Dynamics of a Metabolic Complex, the Purinosome|
S Benkovic, CY Chan, D Kim, A Pedley, X Zhuang
The FASEB Journal 30 (1_supplement), 240.1-240.1, 2016
|Molecular features that define specific PCNA-protein interactions in DNA repair|
AM Pedley, LN Paul, VJ Davisson
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245, 2013
|Targeting PCNA Phosphorylation in Breast Cancer|
VJ Davisson, A Pedley, Q Chen, M Bartolowits, R Fatig
PURDUE UNIV LAFAYETTE IN, 2013
|Identifying cancer genome-wide small molecule synthetic lethality in PCNA interaction networks|
AM Pedley, AA Bieberich, VJ Davisson
The FASEB Journal 27 (1_supplement), 614.7-614.7, 2013
|Evaluation of Proliferating Cell Nuclear Antigen as a Therapeutic Target in DNA Repair|