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Rick Pearson
Rick Pearson
Group Leader, Peter MacCallum Cancer Centre
E-mail confirmado em petermac.org
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[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations
RB Pearson, BE Kemp
Methods in enzymology 200, 62-81, 1991
13141991
Protein kinase recognition sequence motifs
BE Kemp, RB Pearson
Trends in biochemical sciences 15 (9), 342-346, 1990
13041990
Rapamycin suppresses 5′ TOP mRNA translation through inhibition of p70s6k
HBJ Jefferies, S Fumagalli, PB Dennis, C Reinhard, RB Pearson, ...
The EMBO journal, 1997
12111997
Mutation of the PIK3CA gene in ovarian and breast cancer
IG Campbell, SE Russell, DYH Choong, KG Montgomery, ML Ciavarella, ...
Cancer research 64 (21), 7678-7681, 2004
11682004
A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase.
HC Cheng, BE Kemp, RB Pearson, AJ Smith, L Misconi, SM Van Patten, ...
Journal of Biological Chemistry 261 (3), 989-992, 1986
6561986
The Akt kinase signals directly to endothelial nitric oxide synthase
BJ Michell, JE Griffiths, KI Mitchelhill, I Rodriguez-Crespo, T Tiganis, ...
Current biology 9 (15), 845-848, 1999
6201999
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ...
Cancer cell 22 (1), 51-65, 2012
5932012
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar …
KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, ...
Molecular and cellular biology, 2003
5872003
The principal target of rapamycin‐induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.
RB Pearson, PB Dennis, JW Han, NA Williamson, SC Kozma, ...
The EMBO journal 14 (21), 5279-5287, 1995
5561995
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
K Jastrzebski, KM Hannan, EB Tchoubrieva, RD Hannan, RB Pearson
Growth factors 25 (4), 209-226, 2007
3182007
Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis
TJ Parmenter, M Kleinschmidt, KM Kinross, ST Bond, J Li, MR Kaadige, ...
Cancer discovery 4 (4), 423-433, 2014
3042014
AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ...
Oncogene 31 (15), 1949-1962, 2012
2942012
STIM1: a novel phosphoprotein located at the cell surface
SSM Manji, NJ Parker, RT Williams, L Van Stekelenburg, RB Pearson, ...
Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2000
2932000
Targeting PI3 kinase/AKT/mTOR signaling in cancer
K Sheppard, KM Kinross, B Solomon, RB Pearson, WA Phillips
Critical Reviews™ in Oncogenesis 17 (1), 2012
2912012
The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.
BE Kemp, RB Pearson, V Guerriero Jr, IC Bagchi, AR Means
Journal of Biological Chemistry 262 (6), 2542-2548, 1987
2871987
Substrate specificity of a multifunctional calmodulin-dependent protein kinase.
RB Pearson, JR Woodgett, P Cohen, BE Kemp
Journal of Biological Chemistry 260 (27), 14471-14476, 1985
2841985
Targeting the nucleolus for cancer intervention
JE Quin, JR Devlin, D Cameron, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (6), 802-816, 2014
2822014
Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy
J Kang, N Brajanovski, KT Chan, J Xuan, RB Pearson, E Sanij
Signal transduction and targeted therapy 6 (1), 323, 2021
2682021
Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis
C Darido, SR Georgy, T Wilanowski, S Dworkin, A Auden, Q Zhao, ...
Cancer cell 20 (5), 635-648, 2011
2632011
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma
O Kondrashova, M Topp, K Nesic, E Lieschke, GY Ho, MI Harrell, ...
Nature communications 9 (1), 3970, 2018
2552018
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