Marcelo Christoffolete
Marcelo Christoffolete
Professor Adjunto
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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
M Watanabe, SM Houten, C Mataki, MA Christoffolete, BW Kim, H Sato, ...
Nature 439 (7075), 484-489, 2006
Perilipin promotes hormone-sensitive lipase-mediated adipocyte lipolysis via phosphorylation-dependent and-independent mechanisms
H Miyoshi, SC Souza, HH Zhang, KJ Strissel, MA Christoffolete, J Kovsan, ...
Journal of Biological Chemistry 281 (23), 15837-15844, 2006
The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate
M Dentice, A Bandyopadhyay, B Gereben, I Callebaut, MA Christoffolete, ...
Nature cell biology 7 (7), 698-705, 2005
Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and …
MA Christoffolete, CCG Linardi, L De Jesus, KN Ebina, SD Carvalho, ...
Diabetes 53 (3), 577-584, 2004
Adaptive activation of thyroid hormone and energy expenditure
AC Bianco, AL Maia, WS Da Silva, MA Christoffolete
Bioscience reports 25 (3-4), 191-208, 2005
Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation
C Curcio-Morelli, AM Zavacki, M Christofollete, B Gereben, ...
Journal of Clinical Investigation 112 (2), 189-196, 2003
The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation
WS Da-Silva, JW Harney, BW Kim, J Li, SDC Bianco, A Crescenzi, ...
Diabetes 56 (3), 767-776, 2007
Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse
AM Zavacki, H Ying, MA Christoffolete, G Aerts, E So, JW Harney, ...
Endocrinology 146 (3), 1568-1575, 2005
Differential effects of central leptin, insulin, or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate …
C Fekete, PS Singru, E Sanchez, S Sarkar, MA Christoffolete, RS Riberio, ...
Endocrinology 147 (1), 520-529, 2006
Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism
MA Christoffolete, R Ribeiro, P Singru, C Fekete, WS Da Silva, DF Gordon, ...
Endocrinology 147 (4), 1735-1743, 2006
Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis
JA Hall, S Ribich, MA Christoffolete, G Simovic, M Correa-Medina, ...
Endocrinology 151 (9), 4573-4582, 2010
β1 Adrenergic receptor is key to cold-and diet-induced thermogenesis in mice
CB Ueta, GW Fernandes, LP Capelo, TL Fonseca, FDA Maculan, ...
The Journal of endocrinology 214 (3), 359, 2012
Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation
CHA Gouveia, MA Christoffolete, CR Zaitune, JM Dora, JW Harney, ...
Endocrinology 146 (1), 195-200, 2005
Evidence of UCP1-independent regulation of norepinephrine-induced thermogenesis in brown fat
MO Ribeiro, FLAS Lebrun, MA Christoffolete, M Branco, A Crescenzi, ...
American Journal of Physiology-Endocrinology and Metabolism 279 (2), E314-E322, 2000
Mice with impaired extrathyroidal thyroxine to 3, 5, 3′-triiodothyronine conversion maintain normal serum 3, 5, 3′-triiodothyronine concentrations
MA Christoffolete, R Arrojo e Drigo, F Gazoni, SM Tente, V Goncalves, ...
Endocrinology 148 (3), 954-960, 2007
Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum …
C Fekete, S Sarkar, MA Christoffolete, CH Emerson, AC Bianco, ...
Brain research 1056 (1), 97-99, 2005
A TRβ-selective agonist confers resistance to diet-induced obesity
BS Amorim, CB Ueta, BCG Freitas, RJ Nassif, CH de Azevedo Gouveia, ...
The Journal of endocrinology 203 (2), 291, 2009
Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue
SC Souza, MA Christoffolete, MO Ribeiro, H Miyoshi, KJ Strissel, ...
Journal of lipid research 48 (6), 1273-1279, 2007
A novel mechanism of thyroid hormone-dependent negative regulation by thyroid hormone receptor, nuclear receptor corepressor (NCoR), and GAGA-binding factor on the rat cD44 …
SW Kim, SC Ho, SJ Hong, KM Kim, EC So, M Christoffolete, JW Harney
Journal of Biological Chemistry 280 (15), 14545-14555, 2005
Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain
C Fekete, BCG Freitas, A Zeöld, G Wittmann, A Kádár, Z Liposits, ...
Endocrinology 148 (10), 4865-4874, 2007
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