| Phthalimide conjugation as a strategy for in vivo target protein degradation GE Winter, DL Buckley, J Paulk, JM Roberts, A Souza, S Dhe-Paganon, ... Science 348 (6241), 1376-1381, 2015 | 1474 | 2015 |
| Catalytic in vivo protein knockdown by small-molecule PROTACs DP Bondeson, A Mares, IED Smith, E Ko, S Campos, AH Miah, ... Nature chemical biology 11 (8), 611-617, 2015 | 1068 | 2015 |
| YY1 is a structural regulator of enhancer-promoter loops AS Weintraub, CH Li, AV Zamudio, AA Sigova, NM Hannett, DS Day, ... Cell 171 (7), 1573-1588. e28, 2017 | 856 | 2017 |
| The dTAG system for immediate and target-specific protein degradation B Nabet, JM Roberts, DL Buckley, J Paulk, S Dastjerdi, A Yang, ... Nature chemical biology 14 (5), 431-441, 2018 | 717 | 2018 |
| Targeting the von Hippel–Lindau E3 ubiquitin ligase using small molecules to disrupt the VHL/HIF-1α interaction DL Buckley, I Van Molle, PC Gareiss, HS Tae, J Michel, DJ Noblin, ... Journal of the American Chemical Society 134 (10), 4465-4468, 2012 | 499 | 2012 |
| Plasticity in binding confers selectivity in ligand-induced protein degradation RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ... Nature chemical biology 14 (7), 706-714, 2018 | 442 | 2018 |
| HaloPROTACS: use of small molecule PROTACs to induce degradation of HaloTag fusion proteins DL Buckley, K Raina, N Darricarrere, J Hines, JL Gustafson, IE Smith, ... ACS chemical biology 10 (8), 1831-1837, 2015 | 402 | 2015 |
| BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment GE Winter, A Mayer, DL Buckley, MA Erb, JE Roderick, S Vittori, JM Reyes, ... Molecular cell 67 (1), 5-18. e19, 2017 | 391 | 2017 |
| A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader HT Huang, D Dobrovolsky, J Paulk, G Yang, EL Weisberg, ZM Doctor, ... Cell chemical biology 25 (1), 88-99. e6, 2018 | 364 | 2018 |
| Small Molecule Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1α DL Buckley, JL Gustafson, I Van Molle, AG Roth, HS Tae, PC Gareiss, ... Angewandte Chemie (International Ed. in English) 51 (46), 11463, 2012 | 308 | 2012 |
| Transcription control by the ENL YEATS domain in acute leukaemia MA Erb, TG Scott, BE Li, H Xie, J Paulk, HS Seo, A Souza, JM Roberts, ... Nature 543 (7644), 270-274, 2017 | 297 | 2017 |
| Degradation of the BAF complex factor BRD9 by heterobifunctional ligands D Remillard, DL Buckley, J Paulk, GL Brien, M Sonnett, HS Seo, ... Angewandte Chemie International Edition 56 (21), 5738-5743, 2017 | 291 | 2017 |
| Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4 X Dai, W Gan, X Li, S Wang, W Zhang, L Huang, S Liu, Q Zhong, J Guo, ... Nature medicine 23 (9), 1063-1071, 2017 | 279 | 2017 |
| Mutant NPM1 maintains the leukemic state through HOX expression L Brunetti, MC Gundry, D Sorcini, AG Guzman, YH Huang, ... Cancer cell 34 (3), 499-512. e9, 2018 | 239 | 2018 |
| Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands LN Gechijian, DL Buckley, MA Lawlor, JM Reyes, J Paulk, CJ Ott, ... Nature chemical biology 14 (4), 405-412, 2018 | 213 | 2018 |
| Dissecting fragment-based lead discovery at the von Hippel-Lindau protein: hypoxia inducible factor 1α protein-protein interface I Van Molle, A Thomann, DL Buckley, EC So, S Lang, CM Crews, A Ciulli Chemistry & biology 19 (10), 1300-1312, 2012 | 203 | 2012 |
| Small‐molecule control of intracellular protein levels through modulation of the ubiquitin proteasome system DL Buckley, CM Crews Angewandte Chemie International Edition 53 (9), 2312-2330, 2014 | 188 | 2014 |
| Small‐molecule‐mediated degradation of the androgen receptor through hydrophobic tagging JL Gustafson, TK Neklesa, CS Cox, AG Roth, DL Buckley, HS Tae, ... Angewandte Chemie 127 (33), 9795-9798, 2015 | 182 | 2015 |
| Compounds and methods for the enhanced degradation of targeted proteins and other polypeptides by an E3 ubiquitin ligase CM Crews, D Buckley, A Ciulli, W Jorgensen, PC Gareiss, I Van Molle, ... US Patent 10,730,862, 2020 | 152 | 2020 |
| Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules B Nabet, FM Ferguson, BKA Seong, M Kuljanin, AL Leggett, ML Mohardt, ... Nature communications 11 (1), 4687, 2020 | 137 | 2020 |
Georg E WinterPrincipal Investigator at CeMM, ViennaE-mail confirmado em cemm.oeaw.ac.at
