The Keap1/Nrf2-ARE Pathway as a Pharmacological Target for Chalcones M de Freitas Silva, L Pruccoli, F Morroni, G Sita, F Seghetti, C Viegas Jr, ... Molecules 23 (7), 1803, 2018 | 89 | 2018 |
Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update M de Freitas Silva, KST Dias, VS Gontijo, CJC Ortiz, J Viegas Current medicinal chemistry 25 (29), 3491-3525, 2018 | 83 | 2018 |
Molecular hybridization as a tool in the design of multi-target directed drug candidates for neurodegenerative diseases VS Gontijo, FPD Viegas, CJC Ortiz, M de Freitas Silva, CM Damasio, ... Current neuropharmacology 18 (5), 348-407, 2020 | 79 | 2020 |
Donepezil: an important prototype to the design of new drug candidates for Alzheimer’s disease M Cecilia Rodrigues Simoes, F Pereira Dias Viegas, M Soares Moreira, ... Mini reviews in medicinal chemistry 14 (1), 2-19, 2014 | 73 | 2014 |
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer … FPD Viegas, M de Freitas Silva, MD da Rocha, MR Castelli, MM Riquiel, ... European journal of medicinal chemistry 147, 48-65, 2018 | 56 | 2018 |
Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells M de Freitas Silva, LF Coelho, IM Guirelli, RM Pereira, GÁ Ferreira-Silva, ... Toxicology in Vitro 50, 75-85, 2018 | 40 | 2018 |
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer’s Disease M de Freitas Silva, E Tardelli Lima, L Pruccoli, NG Castro, ... Molecules 25 (14), 3165, 2020 | 15 | 2020 |
Design of Multi-target Directed Ligands as a Modern Approach for the Development of Innovative Drug Candidates for Alzheimer’s Disease CJC Ortiz, M de Freitas Silva, VS Gontijo, FPD Viegas, KST Dias, ... Humana Press, 2018 | 9 | 2018 |
Synthesis and biological evaluation of 4-hydroxy-methylpiperidinyl-N-benzyl-acylarylhydrazone hybrids designed as novel multifunctional drug candidates for Alzheimer’s disease SM Vaz, M de Freitas Silva, GRR Franco, MJR Guimarães, FMR da Silva, ... Bioorganic & Medicinal Chemistry 71, 116952, 2022 | 6 | 2022 |
Design, synthesis, and biological evaluation of new thalidomide-donepezil hybrids as neuroprotective agents targeting cholinesterases and neuroinflammation CC Ortiz, M de Freitas Silva, L Pruccoli, NF Nadur, LL de Azevedo, ... RSC Medicinal Chemistry, 2022 | 3 | 2022 |
New multifunctional AChE inhibitor drug prototypes protect against Aβ-induced memory deficit PMQ Bellozi, AC Campos, FPD Viegas, MF Silva, RP Machado, SM Vaz, ... Neurological Sciences 41 (2), 451-455, 2020 | 1 | 2020 |