Stephen P O'Brien
Stephen P O'Brien
Novartis Institutes of Biotechnology
E-mail confirmado em novartis.com
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The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine …
A Debant, C Serra-Pagès, K Seipel, S O'Brien, M Tang, SH Park, M Streuli
Proceedings of the National Academy of Sciences 93 (11), 5466-5471, 1996
5601996
Intestinal npt2b plays a major role in phosphate absorption and homeostasis
Y Sabbagh, SP O'Brien, W Song, JH Boulanger, A Stockmann, C Arbeeny, ...
Journal of the American Society of Nephrology 20 (11), 2348-2358, 2009
2942009
Repression of osteocyte Wnt/β‐catenin signaling is an early event in the progression of renal osteodystrophy
Y Sabbagh, FG Graciolli, S O'Brien, W Tang, LM dos Reis, S Ryan, ...
Journal of Bone and Mineral Research 27 (8), 1757-1772, 2012
2292012
Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
SP O'Brien, K Seipel, QG Medley, R Bronson, R Segal, M Streuli
Proceedings of the National Academy of Sciences 97 (22), 12074-12078, 2000
1902000
Thyroid‐stimulating hormone restores bone volume, microarchitecture, and strength in aged ovariectomized rats
TK Sampath, P Simic, R Sendak, N Draca, AE Bowe, S O'Brien, ...
Journal of Bone and Mineral Research 22 (6), 849-859, 2007
1382007
Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition
QG Medley, N Kedersha, S O'Brien, Q Tian, SF Schlossman, M Streuli, ...
Proceedings of the National Academy of Sciences 93 (2), 685-689, 1996
1321996
Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization
K Seipel, SP O'Brien, E Iannotti, QG Medley, M Streuli
Journal of cell science 114 (2), 389-399, 2001
1142001
Npt2b deletion attenuates hyperphosphatemia associated with CKD
SC Schiavi, W Tang, C Bracken, SP O’Brien, W Song, J Boulanger, ...
Journal of the American Society of Nephrology 23 (10), 1691-1700, 2012
1012012
Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR
ARP Beck, QG Medley, S O'Brien, P Anderson, M Streuli
Nucleic acids research 24 (19), 3829-3835, 1996
1001996
Parathyroid hormone treatment induces dissociation of type IIa Na+-Pi cotransporter-Na+/H+ exchanger regulatory factor-1 complexes
N Déliot, N Hernando, Z Horst-Liu, SM Gisler, P Capuano, CA Wagner, ...
American Journal of Physiology-Cell Physiology 289 (1), C159-C167, 2005
912005
Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth
K Seipel, QG Medley, NL Kedersha, XA Zhang, SP O'Brien, ...
Journal of cell science 112 (12), 1825-1834, 1999
721999
Biological activity of FGF-23 fragments
TJ Berndt, TA Craig, DJ McCormick, B Lanske, D Sitara, MS Razzaque, ...
Pflügers Archiv-European Journal of Physiology 454 (4), 615-623, 2007
632007
Secreted frizzled-related protein-4 reduces sodium–phosphate co-transporter abundance and activity in proximal tubule cells
TJ Berndt, B Bielesz, TA Craig, PJ Tebben, D Bacic, CA Wagner, ...
Pflügers Archiv 451 (4), 579-587, 2006
512006
The Trio guanine nucleotide exchange factor is a RhoA target: binding of RhoA to the Trio immunoglobulin-like domain
QG Medley, C Serra-Pagès, E Iannotti, K Seipel, M Tang, SP O'Brien, ...
Journal of Biological Chemistry 275 (46), 36116-36123, 2000
512000
Calcium mediates glomerular filtration through calcineurin and mTORC2/Akt signaling
J Vassiliadis, C Bracken, D Matthews, S O'Brien, S Schiavi, S Wawersik
Journal of the American Society of Nephrology 22 (8), 1453-1461, 2011
482011
GLOMERULOPATHY IN THE KK. Cg-A y/J MOUSE REFLECTS PATHOLOGY OF DIABETIC NEPHROPATHY
SP O’Brien, M Smith, H Ling, L Phillips, W Weber, J Lydon, C Maloney, ...
Journal of Diabetes Research 2013 (Article ID 498925), 13, 2013
192013
CXA-10, a nitrated fatty acid, is renoprotective in deoxycorticosterone acetate-salt nephropathy
CM Arbeeny, H Ling, MM Smith, S O’Brien, S Wawersik, SR Ledbetter, ...
Journal of Pharmacology and Experimental Therapeutics 369 (3), 503-510, 2019
102019
FGF23 and FRP4 internalize sodium-phosphate co-transporter (NaPi2a) in opossum kidney proximal tubule cells.
SP O'Brien, AE Bowe, A Byrne, W Weber, M Pragnell, R Kumar, ...
JOURNAL OF BONE AND MINERAL RESEARCH 18, S330-S330, 2003
32003
Role of FGF23 in surface retrieval of sodium-phosphate co-transporter (NaPi-IIa) in opossum kidney proximal tubule cells.
SP O'Brien, AE Bowe, N Hernando, J Biber, H Murer, R Kumar, ...
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 14, 22A-22A, 2003
12003
Thyroid stimulating hormone (TSH) inhibits osteoclast differentiation of hematopoietic stem cells and stimulates osteoblast differentiation of mesenchymal stem cells derived …
Y Sabbagh, AE Bowe, SP O'Brien, L Agresto, M Prapnell, C Arbeeny, ...
JOURNAL OF BONE AND MINERAL RESEARCH 21, S189-S189, 2006
2006
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