Hamsa Puthalakath
Hamsa Puthalakath
Associate Professor
Verified email at latrobe.edu.au
Cited by
Cited by
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ...
Cell Death & Differentiation 25 (3), 486-541, 2018
ER stress triggers apoptosis by activating BH3-only protein Bim
H Puthalakath, LA O'Reilly, P Gunn, L Lee, PN Kelly, ND Huntington, ...
Cell 129 (7), 1337-1349, 2007
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
H Puthalakath, DCS Huang, LA O’Reilly, SM King, A Strasser
Molecular cell 3 (3), 287-296, 1999
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
P Bouillet, JF Purton, DI Godfrey, LC Zhang, L Coultas, H Puthalakath, ...
Nature 415 (6874), 922-926, 2002
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins.
H Puthalakath, A Strasser
Cell Death and Differentiation 9 (5), 505-512, 2002
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L Galluzzi, JM Bravo-San Pedro, I Vitale, SA Aaronson, JM Abrams, ...
Cell Death & Differentiation 22 (1), 58-73, 2015
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
H Puthalakath, A Villunger, LA O'Reilly, JG Beaumont, L Coultas, ...
Science 293 (5536), 1829-1832, 2001
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
L Galluzzi, SA Aaronson, J Abrams, ES Alnemri, DW Andrews, ...
Cell Death & Differentiation 16 (8), 1093-1107, 2009
Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
J Kuroda, H Puthalakath, MS Cragg, PN Kelly, P Bouillet, DCS Huang, ...
Proceedings of the National Academy of Sciences 103 (40), 14907-14912, 2006
Gefitinib-Induced Killing of NSCLC Cell Lines Expressing Mutant EGFR Requires BIM and Can Be Enhanced by BH3 Mimetics
MS Cragg, J Kuroda, H Puthalakath, DCS Huang, A Strasser
PLoS medicine 4 (10), e316, 2007
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation–induced apoptosis and deletion of autoreactive B cells
A Enders, P Bouillet, H Puthalakath, Y Xu, DM Tarlinton, A Strasser
The Journal of experimental medicine 198 (7), 1119-1126, 2003
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3: groove interactions
G Dewson, T Kratina, HW Sim, H Puthalakath, JM Adams, PM Colman, ...
Molecular cell 30 (3), 369-380, 2008
Interleukin 15–mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
ND Huntington, H Puthalakath, P Gunn, E Naik, EM Michalak, MJ Smyth, ...
Nature immunology 8 (8), 856-863, 2007
Bcl‐2 family proteins: The sentinels of the mitochondrial apoptosis pathway
WWL Wong, H Puthalakath
IUBMB life 60 (6), 390-397, 2008
Egalitarian binds dynein light chain to establish oocyte polarity and maintain oocyte fate
C Navarro, H Puthalakath, JM Adams, A Strasser, R Lehmann
Nature cell biology 6 (5), 427-435, 2004
The Role of Bim, a Proapoptotic BH3‐Only Member of the Bcl‐2 Family, in Cell‐Death Control
A Strasser, H Puthalakath, P Bouillet, DCS Huang, L O'CONNOR, ...
Annals of the New York Academy of Sciences 917 (1), 541-548, 2000
A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation
EF Lee, PE Czabotar, MF Van Delft, EM Michalak, MJ Boyle, SN Willis, ...
Journal of Cell Biology 180 (2), 341-355, 2008
Fatal hepatitis mediated by tumor necrosis factor TNFα requires caspase-8 and involves the BH3-only proteins Bid and Bim
T Kaufmann, PJ Jost, M Pellegrini, H Puthalakath, R Gugasyan, ...
Immunity 30 (1), 56-66, 2009
Therapeutic molecules
S Cory, J Adams, DCS Huang, L O'connor, A Strasser, H Puthalakath, ...
US Patent 7,064,193, 2006
Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands
CL Day, H Puthalakath, G Skea, A Strasser, I Barsukov, LY Lian, ...
Biochemical Journal 377 (3), 597-605, 2004
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