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Petros Tyrakis
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An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
RSJ Asis Palazon, Petros A. Tyrakis, David Macias, Pedro Velica, Helene ...
Cancer Cell 32 (5), 669-683, 2017
4102017
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
PA Tyrakis, A Palazon, D Macias, KL Lee, AT Phan, P Veliça, J You, ...
Nature 540 (7632), 236-241, 2016
3582016
Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection
AT Phan, AL Doedens, A Palazon, PA Tyrakis, KP Cheung, RS Johnson, ...
Immunity 45 (5), 1024-1037, 2016
2002016
A Late‐Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster
ME Yurkovich, PA Tyrakis, H Hong, Y Sun, M Samborskyy, K Kamiya, ...
ChemBioChem 13 (1), 66-71, 2012
802012
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
CF PA Tyrakis, ME Yurkovich, M Sciacovelli, EK Papachristou, HR Bridges, E ...
Cell Reports 21 (4), 1036-1047, 2017
752017
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
J Sim, AS Cowburn, A Palazon, B Madhu, PA Tyrakis, D Macías, ...
Cell Metabolism 27 (4), 898-913. e7, 2018
732018
Mycobacterium tuberculosis dihydrofolate reductase reveals two conformational states and a possible low affinity mechanism to antifolate drugs
MVB Dias, P Tyrakis, RR Domingues, AFP Leme, TL Blundell
Structure 22 (1), 94-103, 2014
362014
Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
CE Evans, A Palazon, J Sim, PA Tyrakis, A Prodger, X Lu, S Chan, ...
Biology Open, 2017
212017
Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis
JA Ribeiro, A Hammer, GA Libreros-Zuniga, SM Chavez-Pacheco, ...
ACS Infectious Diseases 6 (8), 2192-2201, 2020
162020
Using a fragment-based approach to identify novel chemical scaffolds targeting the dihydrofolate reductase (DHFR) from Mycobacterium tuberculosis
JA Ribeiro, A Hammer, GAL Zuniga, SM Chavez-Pacheco, P Tyrakis, ...
bioRxiv, 2020
12020
Methods Of T-Lymphocyte Expansion
RS Johnson, A PALAZON, PA Tyrakis
US Patent App. 15/772,782, 2019
2019
Identification of new molecules that bind to the enzyme dihydrofolate reductase of Mycobacterium tuberculosis.
GA Libreros-Zúñiga, JA Ribeiro, A Hammer, SM Chávez-Pacheco, ...
Biomédica 39 (Suppl. 4), 28-29, 2019
2019
Methods of t-lymphocyte expansion
R Johnson, GFDA Palazon, PA TYRAKIS
2017
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