Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines IV Pavlidis, MS Weiß, M Genz, P Spurr, SP Hanlon, B Wirz, H Iding, ... Nature chemistry 8 (11), 1076-1082, 2016 | 236 | 2016 |
The use of enzymes in organic synthesis and the life sciences: perspectives from the Swiss Industrial Biocatalysis Consortium (SIBC) HP Meyer, E Eichhorn, S Hanlon, S Lütz, M Schürmann, R Wohlgemuth, ... Catalysis Science & Technology 3 (1), 29-40, 2013 | 158 | 2013 |
Asymmetric reductive amination of ketones catalyzed by imine reductases D Wetzl, M Gand, A Ross, H Müller, P Matzel, SP Hanlon, M Müller, B Wirz, ... ChemCatChem 8 (12), 2023-2026, 2016 | 136 | 2016 |
Expanding the imine reductase toolbox by exploring the bacterial protein‐sequence space D Wetzl, M Berrera, N Sandon, D Fishlock, M Ebeling, M Müller, S Hanlon, ... ChemBioChem 16 (12), 1749-1756, 2015 | 132 | 2015 |
Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli DF McGinnity, SJ Griffin, GC Moody, M Voice, S Hanlon, T Friedberg, ... Drug metabolism and disposition 27 (9), 1017-1023, 1999 | 75 | 1999 |
Isolation and characterization of a strain of Rhodobacter sulfidophilus: A bacterium which grows autotrophically with dimethylsulphide as electron donor SP Hanlon, RA Holt, GR Moore, AG McEwan Microbiology 140 (8), 1953-1958, 1994 | 71 | 1994 |
Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison T Friedberg, MP Pritchard, M Bandera, SP Hanlon, D Yao, LA McLaughlin, ... Drug metabolism reviews 31 (2), 523-544, 1999 | 65 | 1999 |
Amine transaminase engineering for spatially bulky substrate acceptance MS Weiß, IV Pavlidis, P Spurr, SP Hanlon, B Wirz, H Iding, ... ChemBioChem 18 (11), 1022-1026, 2017 | 56 | 2017 |
Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine MS Weiß, IV Pavlidis, P Spurr, SP Hanlon, B Wirz, H Iding, ... Organic & biomolecular chemistry 14 (43), 10249-10254, 2016 | 55 | 2016 |
Human enzymes for organic synthesis M Winkler, M Geier, SP Hanlon, B Nidetzky, A Glieder Angewandte Chemie International Edition 57 (41), 13406-13423, 2018 | 53 | 2018 |
The organic–synthetic potential of recombinant ene reductases: substrate‐scope evaluation and process optimization T Reß, W Hummel, SP Hanlon, H Iding, H Gröger ChemCatChem 7 (8), 1302-1311, 2015 | 51 | 2015 |
Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism DN Li, MP Pritchard, SP Hanlon, B Burchell, CR Wolf, T Friedberg Journal of Pharmacology and Experimental Therapeutics 289 (2), 661-667, 1999 | 46 | 1999 |
2-Phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression SP Hanlon, TK Hill, MA Flavell, JM Stringfellow, RA Cooper Microbiology 143 (2), 513-518, 1997 | 45 | 1997 |
Expression of recombinant human flavin monooxygenase and moclobemide-N-oxide synthesis on multi-mg scale SP Hanlon, A Camattari, S Abad, A Glieder, M Kittelmann, S Lütz, B Wirz, ... Chemical communications 48 (48), 6001-6003, 2012 | 44 | 2012 |
Development of a Scalable Synthesis of (S)-3-Fluoromethyl-γ-butyrolactone, Building Block for Carmegliptin’s Lactam Moiety JM Adam, J Foricher, S Hanlon, B Lohri, G Moine, R Schmid, H Stahr, ... Organic Process Research & Development 15 (3), 515-526, 2011 | 37 | 2011 |
Asymmetric reduction of racemic sulfoxides by dimethyl sulfoxide reductases from Rhodobacter capsulatus, Escherichia coli and Proteus species SP Hanlon, DL Graham, PJ Hogan, RA Holt, CD Reeve, AL Shaw, ... Microbiology 144 (8), 2247-2253, 1998 | 34 | 1998 |
Dimethylsulfide:Acceptor Oxidoreductase from Rhodobacter sulfidophilus The Purified Enzyme Contains b ‐Type Haem and a Pterin Molybdenum Cofactor SP Hanlon, TH Toh, PS Solomon, RA Holt, AG Mcewan European journal of biochemistry 239 (2), 391-396, 1996 | 32 | 1996 |
Biocatalysis in the fine chemical and pharmaceutical industries PW Sutton, JP Adams, I Archer, D Auriol, M Avi, C Branneby, AJ Collis, ... Practical methods for biocatalysis and biotransformations 2, 1-59, 2012 | 29 | 2012 |
Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis M Geier, T Bachler, SP Hanlon, FK Eggimann, M Kittelmann, H Weber, ... Microbial cell factories 14, 1-10, 2015 | 26 | 2015 |
The 44-kDa c-type cytochrome induced in Rhodobacter capsulatus during growth with dimethylsulphoxide as an electron acceptor is a cytochrome c peroxidase SP Hanlon, RA Holt, AG McEwan FEMS microbiology letters 97 (3), 283-287, 1992 | 25 | 1992 |