| The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling LAJ O'Neill, AG Bowie Nature Reviews Immunology 7 (5), 353-364, 2007 | 3400 | 2007 |
| Succinate is an inflammatory signal that induces IL-1β through HIF-1α GM Tannahill, AM Curtis, J Adamik, EM Palsson-McDermott, ... Nature 496 (7444), 238-242, 2013 | 3398 | 2013 |
| A guide to immunometabolism for immunologists LAJ O'Neill, RJ Kishton, J Rathmell Nature reviews immunology 16 (9), 553-565, 2016 | 2527 | 2016 |
| A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ... Nature medicine 21 (3), 248-255, 2015 | 2285 | 2015 |
| Trained immunity: a program of innate immune memory in health and disease MG Netea, LAB Joosten, E Latz, KHG Mills, G Natoli, HG Stunnenberg, ... Science 352 (6284), aaf1098, 2016 | 2179 | 2016 |
| The history of Toll-like receptors—redefining innate immunity LAJ O'neill, D Golenbock, AG Bowie Nature Reviews Immunology 13 (6), 453-460, 2013 | 2096 | 2013 |
| Negative regulation of toll-like receptor-mediated immune responses FY Liew, D Xu, EK Brint, LAJ O'Neill Nature Reviews Immunology 5 (6), 446-458, 2005 | 1898 | 2005 |
| mTOR-and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity SC Cheng, J Quintin, RA Cramer, KM Shepardson, S Saeed, V Kumar, ... science 345 (6204), 1250684, 2014 | 1817 | 2014 |
| Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction KA Fitzgerald, EM Palsson-McDermott, AG Bowie, CA Jefferies, ... Nature 413 (6851), 78-83, 2001 | 1688 | 2001 |
| Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages EL Mills, B Kelly, A Logan, ASH Costa, M Varma, CE Bryant, ... Cell 167 (2), 457-470. e13, 2016 | 1657 | 2016 |
| Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4 EM Pålsson‐McDermott, LAJ O'Neill Immunology 113 (2), 153-162, 2004 | 1597 | 2004 |
| Metabolic reprogramming in macrophages and dendritic cells in innate immunity B Kelly, LA O'neill Cell research 25 (7), 771-784, 2015 | 1555 | 2015 |
| Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes SL Masters, A Dunne, SL Subramanian, RL Hull, GM Tannahill, FA Sharp, ... Nature immunology 11 (10), 897-904, 2010 | 1424 | 2010 |
| Immunometabolism governs dendritic cell and macrophage function LAJ O’Neill, EJ Pearce Journal of Experimental Medicine 213 (1), 15-23, 2016 | 1401 | 2016 |
| Resolution of inflammation: state of the art, definitions and terms CN Serhan, SD Brain, CD Buckley, DW Gilroy, C Haslett, LAJ O’Neill, ... FASEB journal: official publication of the Federation of American Societies …, 2007 | 1385 | 2007 |
| NF-kB: a crucial transcription factor for glial and neuronal cell function LAJ O'Neill, C Kaltschmidt Trends in neurosciences 20 (6), 252-258, 1997 | 1355 | 1997 |
| Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1272 | 2018 |
| Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 FJ Sheedy, E Palsson-McDermott, EJ Hennessy, C Martin, JJ O'leary, ... Nature immunology 11 (2), 141-147, 2010 | 1186 | 2010 |
| Metabolism of inflammation limited by AMPK and pseudo-starvation LAJ O'Neill, DG Hardie Nature 493 (7432), 346-355, 2013 | 1179 | 2013 |
| Oxidative stress and nuclear factor-κB activation: a reassessment of the evidence in the light of recent discoveries A Bowie, LAJ O’Neill Biochemical pharmacology 59 (1), 13-23, 2000 | 1171 | 2000 |
