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Núbia Boechat
Núbia Boechat
Tecnologista senior da Fundação Oswaldo Cruz
E-mail confirmado em far.fiocruz.br
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Recently reported biological activities of pyrazole compounds
JV Faria, PF Vegi, AGC Miguita, MS Dos Santos, N Boechat, ...
Bioorganic & medicinal chemistry 25 (21), 5891-5903, 2017
3802017
Novel 1,2,3-Triazole Derivatives for Use against Mycobacterium tuberculosis H37Rv (ATCC 27294) Strain
N Boechat, VF Ferreira, SB Ferreira, MLG Ferreira, FC da Silva, ...
Journal of medicinal chemistry 54 (17), 5988-5999, 2011
3092011
Synthesis, tuberculosis inhibitory activity, and SAR study of N-substituted-phenyl-1, 2, 3-triazole derivatives
MS Costa, N Boechat, EA Rangel, FC Da Silva, AMT De Souza, ...
Bioorganic & medicinal chemistry 14 (24), 8644-8653, 2006
2512006
The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
CQ Sacramento, GR de Melo, CS de Freitas, N Rocha, LVB Hoelz, ...
Scientific reports 7 (1), 40920, 2017
2372017
Design, synthesis, and antiviral activity of new 1H-1,2,3-triazole nucleoside ribavirin analogs
M de Lourdes G. Ferreira, LCS Pinheiro, OA Santos-Filho, MDS Peçanha, ...
Medicinal Chemistry Research 23, 1501-1511, 2014
1342014
Synthesis and evaluation of new difluoromethyl azoles as antileishmanial agents
SB Ferreira, MS Costa, N Boechat, RJS Bezerra, MS Genestra, ...
European Journal of Medicinal Chemistry 42 (11-12), 1388-1395, 2007
1102007
Synthesis, antimalarial activity, and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate
F de Pilla Varotti, ACC Botelho, AA Andrade, RC de Paula, ...
Antimicrobial Agents and Chemotherapy 52 (11), 3868-3874, 2008
1052008
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo
CS de Freitas, LM Higa, CQ Sacramento, AC Ferreira, PA Reis, ...
PLoS neglected tropical diseases 13 (1), e0007072, 2019
1042019
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication
AC Ferreira, PA Reis, CS de Freitas, CQ Sacramento, L Villas Bôas Hoelz, ...
Antimicrobial agents and chemotherapy 63 (2), 10.1128/aac. 01389-18, 2019
892019
Current antimalarial therapies and advances in the development of semi-synthetic artemisinin derivatives
L Pinheiro, LM Feitosa, FF SILVEIRA, N Boechat
Anais da Academia Brasileira de Ciências 90, 1251-1271, 2018
842018
New Compounds Hybrids 1H‐1,2,3‐Triazole‐Quinoline Against Plasmodium falciparum
N Boechat, MLG Ferreira, LCS Pinheiro, AML Jesus, MMM Leite, ...
Chemical Biology & Drug Design 84 (3), 325-332, 2014
822014
Novel 1H-1,2,3-, 2H-1,2,3-, 1H-1,2,4- and 4H-1,2,4-triazole derivatives: a patent review (2008 – 2011)
VF Ferreira, DR da Rocha, FC da Silva, PG Ferreira, NA Boechat, ...
Expert Opinion on Therapeutic Patents 23 (3), 319-331, 2013
732013
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19
CQ Sacramento, N Fintelman-Rodrigues, JR Temerozo, APD Da Silva, ...
Journal of Antimicrobial Chemotherapy 76 (7), 1874-1885, 2021
702021
Evaluation of 7-arylaminopyrazolo [1, 5-a] pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
LFSP Azeredo, JP Coutinho, VAP Jabor, PR Feliciano, MC Nonato, ...
European Journal of Medicinal Chemistry 126, 72-83, 2017
702017
New Trifluoromethyl Triazolopyrimidines as Anti-Plasmodiumfalciparum Agents
N Boechat, LCS Pinheiro, TS Silva, ACC Aguiar, AS Carvalho, MM Bastos, ...
Molecules 17 (7), 8285-8302, 2012
702012
A synthesis of 3-fluoroindoles and 3, 3-difluoroindolines by reduction of 3, 3-difluoro-2-oxindoles using a borane tetrahydrofuran complex
JC Torres, SJ Garden, AC Pinto, FSQ da Silva, N Boechat
Tetrahedron 55 (7), 1881-1892, 1999
681999
Design and Synthesis of New N-(5-Trifluoromethyl)-1H-1,2,4-triazol-3-yl Benzenesulfonamides as Possible Antimalarial Prototypes
N Boechat, LCS Pinheiro, OA Santos-Filho, IC Silva
Molecules 16 (9), 8083-8097, 2011
672011
The development of novel compounds against malaria: quinolines, triazolpyridines, pyrazolopyridines and pyrazolopyrimidines
L CS Pinheiro, L M. Feitosa, M O. Gandi, F F. Silveira, N Boechat
Molecules 24 (22), 4095, 2019
622019
Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry
MM Bastos, CCP Costa, TC Bezerra, FC da Silva, N Boechat
European journal of medicinal chemistry 108, 455-465, 2016
582016
A simple reduction of methyl aromatic esters to alcohols using sodium borohydride–methanol system
N Boechat, JCS da Costa, J de Souza Mendonça, PSM de Oliveira, ...
Tetrahedron letters 45 (31), 6021-6022, 2004
562004
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