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Johannes Linder
Johannes Linder
Calico Labs
E-mail confirmado em calicolabs.com
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Ano
A deep neural network for predicting and engineering alternative polyadenylation
N Bogard, J Linder, AB Rosenberg, G Seelig
Cell 178 (1), 91-106. e23, 2019
1652019
A generative neural network for maximizing fitness and diversity of synthetic DNA and protein sequences
J Linder, N Bogard, AB Rosenberg, G Seelig
Cell systems 11 (1), 49-62. e16, 2020
99*2020
Fast activation maximization for molecular sequence design
J Linder, G Seelig
BMC bioinformatics 22, 1-20, 2021
45*2021
Interpreting neural networks for biological sequences by learning stochastic masks
J Linder, A La Fleur, Z Chen, A Ljubetič, D Baker, S Kannan, G Seelig
Nature machine intelligence 4 (1), 41-54, 2022
192022
Deciphering the impact of genetic variation on human polyadenylation using APARENT2
J Linder, SE Koplik, A Kundaje, G Seelig
Genome biology 23 (1), 232, 2022
172022
Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation
J Linder, D Srivastava, H Yuan, V Agarwal, DR Kelley
bioRxiv, 2023.08. 30.555582, 2023
102023
Robust digital molecular design of binarized neural networks
J Linder, YJ Chen, D Wong, G Seelig, L Ceze, K Strauss
27th International Conference on DNA Computing and Molecular Programming …, 2021
52021
CPA-Perturb-seq: Multiplexed single-cell characterization of alternative polyadenylation regulators
MH Kowalski, HH Wessels, J Linder, S Choudhary, A Hartman, Y Hao, ...
BioRxiv, 2023
32023
The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery
L Liu, AM Yu, X Wang, LV Soles, X Teng, Y Chen, Y Yoon, KSK Sarkan, ...
Nature Structural & Molecular Biology 30 (12), 1947-1957, 2023
22023
Optimizing 5'UTRs for mRNA-delivered gene editing using deep learning
S Castillo Hair, S Fedak, B Wang, J Linder, K Havens, M Certo, G Seelig
bioRxiv, 2023.06. 15.545194, 2023
22023
Rewriting regulatory DNA to dissect and reprogram gene expression
GE Martyn, MT Montgomery, H Jones, K Guo, BR Doughty, J Linder, ...
bioRxiv, 2023.12. 20.572268, 2023
22023
Efficient inference of nonlinear feature attributions with scrambling neural networks
J Linder, A LaFleur, S Kannan, Z Chen, A Ljubetic, D Baker, G Seelig
Proceedings of the 2nd Conference on Machine Learning in Computational Biology, 2020
12020
Neural networks implemented with dsd circuits
K Strauss, L Ceze, JSA Linder
US Patent App. 18/204,363, 2023
2023
Neural networks implemented with DSD circuits
K Strauss, L Ceze, JSA Linder
US Patent 11,704,575, 2023
2023
Optimizing 5'UTRs for mRNA-delivered gene editing using deep learning
S Fedak, B Wang, J Linder, K Havens, M Certo, G Seelig
2023
Deciphering the Impact of Genetic Variation on Human Polyadenylation
J Linder, A Kundaje, G Seelig
bioRxiv, 2022.05. 09.491198, 2022
2022
Predicting, Engineering and Interpreting Gene Regulatory Sequences and Proteins with Deep Learning
JSA Linder
University of Washington, 2021
2021
Modeling the intronic regulation of Alternative Splicing using Deep Convolutional Neural Nets
J Linder
2015
Interpreting Neural Networks for Biological Sequences by Learning Masks
J Linder, A La Fleur, S Kannan, Z Chen, A Ljubetič, D Baker, G Seelig
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