| Visualizing a correlation between siRNA localization, cellular uptake, and RNAi in living cells YL Chiu, A Ali, C Chu, H Cao, TM Rana Chemistry & biology 11 (8), 1165-1175, 2004 | 502 | 2004 |
| The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors KP Romano, A Ali, C Aydin, D Soumana, A Özen, LM Deveau, C Silver, ... PLoS pathogens 8 (7), e1002832, 2012 | 245 | 2012 |
| Small-molecule inhibition of HIV-1 Vif R Nathans, H Cao, N Sharova, A Ali, M Sharkey, R Stranska, ... Nature biotechnology 26 (10), 1187-1192, 2008 | 243 | 2008 |
| Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding KP Romano, A Ali, WE Royer, CA Schiffer Proceedings of the National Academy of Sciences 107 (49), 20986-20991, 2010 | 216 | 2010 |
| Molecular basis for drug resistance in HIV-1 protease A Ali, RM Bandaranayake, Y Cai, NM King, M Kolli, S Mittal, JF Murzycki, ... Viruses 2 (11), 2509-2535, 2010 | 171 | 2010 |
| HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants MD Altman, A Ali, GSK Kumar Reddy, MNL Nalam, SG Anjum, H Cao, ... Journal of the American Chemical Society 130 (19), 6099-6113, 2008 | 143 | 2008 |
| First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G M Li, SMD Shandilya, MA Carpenter, A Rathore, WL Brown, AL Perkins, ... ACS chemical biology 7 (3), 506-517, 2012 | 139 | 2012 |
| Evaluating the substrate-envelope hypothesis: structural analysis of novel HIV-1 protease inhibitors designed to be robust against drug resistance MNL Nalam, A Ali, MD Altman, GSKK Reddy, S Chellappan, V Kairys, ... Journal of Virology 84 (10), 5368-5378, 2010 | 134 | 2010 |
| Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands A Ali, GSKK Reddy, H Cao, SG Anjum, MNL Nalam, CA Schiffer, TM Rana Journal of medicinal chemistry 49 (25), 7342-7356, 2006 | 133 | 2006 |
| P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates M Sansó, RS Levin, JJ Lipp, VYF Wang, AK Greifenberg, EM Quezada, ... Genes & development 30 (1), 117-131, 2016 | 129 | 2016 |
| Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis A Fazly, C Jain, AC Dehner, L Issi, EA Lilly, A Ali, H Cao, PL Fidel Jr, ... Proceedings of the National Academy of Sciences 110 (33), 13594-13599, 2013 | 117 | 2013 |
| Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication S Hwang, N Tamilarasu, K Kibler, H Cao, A Ali, YH Ping, KT Jeang, ... Journal of Biological Chemistry 278 (40), 39092-39103, 2003 | 101 | 2003 |
| Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188 GJ Lockbaum, AC Reyes, JM Lee, R Tilvawala, EA Nalivaika, A Ali, ... Viruses 13 (2), 174, 2021 | 96 | 2021 |
| Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2 ‘Ligands in Pseudosymmetric Dipeptide Isosteres GSKK Reddy, A Ali, MNL Nalam, SG Anjum, H Cao, RS Nathans, ... Journal of medicinal chemistry 50 (18), 4316-4328, 2007 | 77 | 2007 |
| Design of mutation‐resistant HIV protease inhibitors with the substrate envelope hypothesis S Chellappan, GS Kiran Kumar Reddy, A Ali, MNL Nalam, SG Anjum, ... Chemical biology & drug design 69 (5), 298-313, 2007 | 73 | 2007 |
| Evaluating the role of macrocycles in the susceptibility of hepatitis C virus NS3/4A protease inhibitors to drug resistance A Ali, C Aydin, R Gildemeister, KP Romano, H Cao, A Özen, D Soumana, ... ACS chemical biology 8 (7), 1469-1478, 2013 | 71 | 2013 |
| Structure-based design, synthesis, and structure− activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones A Ali, GSKK Reddy, MNL Nalam, SG Anjum, H Cao, CA Schiffer, TM Rana Journal of medicinal chemistry 53 (21), 7699-7708, 2010 | 68 | 2010 |
| Molecular and dynamic mechanism underlying drug resistance in genotype 3 hepatitis C NS3/4A protease DI Soumana, N Kurt Yilmaz, A Ali, KL Prachanronarong, CA Schiffer Journal of the American Chemical Society 138 (36), 11850-11859, 2016 | 67 | 2016 |
| Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance MNL Nalam, A Ali, GSKK Reddy, H Cao, SG Anjum, MD Altman, ... Chemistry & biology 20 (9), 1116-1124, 2013 | 65 | 2013 |
| Structural analysis of asunaprevir resistance in HCV NS3/4A protease DI Soumana, A Ali, CA Schiffer ACS chemical biology 9 (11), 2485-2490, 2014 | 63 | 2014 |
Celia A SchifferProfessor and Chair of Biochemistry and Molecular Biotechnology, U Mass Chan Medical SchoolE-mail confirmado em umassmed.edu
