| Regulation of ferroptotic cancer cell death by GPX4 WS Yang, R SriRamaratnam, ME Welsch, K Shimada, R Skouta, ... Cell 156 (1), 317-331, 2014 | 4811 | 2014 |
| Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway VS Viswanathan, MJ Ryan, HD Dhruv, S Gill, OM Eichhoff, ... Nature 547 (7664), 453-457, 2017 | 1353 | 2017 |
| Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models R Skouta, SJ Dixon, J Wang, DE Dunn, M Orman, K Shimada, ... Journal of the American Chemical Society 136 (12), 4551-4556, 2014 | 904 | 2014 |
| Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis K Shimada, R Skouta, A Kaplan, WS Yang, M Hayano, SJ Dixon, ... Nature chemical biology 12 (7), 497-503, 2016 | 790 | 2016 |
| Cell-line selectivity improves the predictive power of pharmacogenomic analyses and helps identify NADPH as biomarker for ferroptosis sensitivity K Shimada, M Hayano, NC Pagano, BR Stockwell Cell chemical biology 23 (2), 225-235, 2016 | 249 | 2016 |
| Development of small-molecule probes that selectively kill cells induced to express mutant RAS M Weïwer, JA Bittker, TA Lewis, K Shimada, WS Yang, L MacPherson, ... Bioorganic & medicinal chemistry letters 22 (4), 1822-1826, 2012 | 193 | 2012 |
| Modulatory profiling identifies mechanisms of small molecule-induced cell death AJ Wolpaw, K Shimada, R Skouta, ME Welsch, UD Akavia, D Pe'er, ... Proceedings of the National Academy of Sciences 108 (39), E771-E780, 2011 | 142 | 2011 |
| Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay AG Herman, M Hayano, MV Poyurovsky, K Shimada, R Skouta, C Prives, ... Cancer discovery 1 (4), 312-325, 2011 | 106 | 2011 |
| Identification of simple compounds with microtubule-binding activity that inhibit cancer cell growth with high potency WS Yang, K Shimada, D Delva, M Patel, E Ode, R Skouta, BR Stockwell Acs Medicinal Chemistry Letters 3 (1), 35-38, 2012 | 76 | 2012 |
| Copper-binding small molecule induces oxidative stress and cell-cycle arrest in glioblastoma-patient-derived cells K Shimada, E Reznik, ME Stokes, L Krishnamoorthy, PH Bos, Y Song, ... Cell chemical biology 25 (5), 585-594. e7, 2018 | 72 | 2018 |
| Unraveling the mechanism of cell death induced by chemical fibrils O Julien, M Kampmann, MC Bassik, JA Zorn, VJ Venditto, K Shimbo, ... Nature chemical biology 10 (11), 969-976, 2014 | 55 | 2014 |
| shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data K Shimada, JA Bachman, JL Muhlich, TJ Mitchison Elife 10, e57116, 2021 | 53 | 2021 |
| Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation JH Weng, PD Koch, HH Luan, HC Tu, K Shimada, I Ngan, R Ventura, ... Nature metabolism 3 (4), 513-522, 2021 | 42 | 2021 |
| Human pluripotency is initiated and preserved by a unique subset of founder cells M Nakanishi, RR Mitchell, YD Benoit, L Orlando, JC Reid, K Shimada, ... Cell 177 (4), 910-924. e22, 2019 | 39 | 2019 |
| Design and synthesis of Pictet–Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death R Skouta, M Hayano, K Shimada, BR Stockwell Bioorganic & medicinal chemistry letters 22 (17), 5707-5713, 2012 | 36 | 2012 |
| tRNA synthase suppression activates de novo cysteine synthesis to compensate for cystine and glutathione deprivation during ferroptosis K Shimada, BR Stockwell Molecular & cellular oncology 3 (2), e1091059, 2016 | 33 | 2016 |
| Transdermal delivery of a readthrough-inducing drug: a new approach of gentamicin administration for the treatment of nonsense mutation-mediated disorders M Shiozuka, A Wagatsuma, T Kawamoto, H Sasaki, K Shimada, ... The journal of biochemistry 147 (4), 463-470, 2010 | 25 | 2010 |
| Unsupervised identification of disease states from high‐dimensional physiological and histopathological profiles K Shimada, TJ Mitchison Molecular Systems Biology 15 (2), e8636, 2019 | 15 | 2019 |
| A tool for browsing the Cancer Dependency Map reveals functional connections between genes and helps predict the efficacy and selectivity of candidate cancer drugs K Shimada, JL Muhlich, TJ Mitchison bioRxiv, 2019.12. 13.874776, 2019 | 11 | 2019 |
| Screen for RAS-selective lethal compounds and VDAC ligands JA Bittker, M Weiwer, K Shimada, WS Yang, L MacPherson, S Dandapani, ... probe 1, 2010 | 10 | 2010 |
