Jonathon Winnay
Jonathon Winnay
Joslin Diabetes Center, Harvard Medical School
E-mail confirmado em joslin.harvard.edu
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Tissue-specific knockout of the insulin receptor in pancreatic β cells creates an insulin secretory defect similar to that in type 2 diabetes
RN Kulkarni, JC Brüning, JN Winnay, C Postic, MA Magnuson, CR Kahn
Cell 96 (3), 329-339, 1999
13121999
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
JC Brüning, MD Michael, JN Winnay, T Hayashi, D Hörsch, D Accili, ...
Molecular cell 2 (5), 559-569, 1998
12381998
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
YH Tseng, E Kokkotou, TJ Schulz, TL Huang, JN Winnay, CM Taniguchi, ...
Nature 454 (7207), 1000-1004, 2008
10542008
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
YH Tseng, E Kokkotou, TJ Schulz, TL Huang, JN Winnay, CM Taniguchi, ...
Nature 454 (7207), 1000-1004, 2008
10542008
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
JC Brüning, J Winnay, S Bonner-Weir, SI Taylor, D Accili, CR Kahn
Cell 88 (4), 561-572, 1997
6411997
Adipose-derived circulating miRNAs regulate gene expression in other tissues
T Thomou, MA Mori, JM Dreyfuss, M Konishi, M Sakaguchi, C Wolfrum, ...
Nature 542 (7642), 450-455, 2017
6042017
Altered function of insulin receptor substrate-1–deficient mouse islets and cultured β-cell lines
RN Kulkarni, JN Winnay, M Daniels, JC Brüning, SN Flier, D Hanahan, ...
The Journal of clinical investigation 104 (12), R69-R75, 1999
3131999
PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance
RN Kulkarni, US Jhala, JN Winnay, S Krajewski, M Montminy, CR Kahn
The Journal of clinical investigation 114 (6), 828-836, 2004
2802004
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells.
JC Brüning, J Winnay, B Cheatham, CR Kahn
Molecular and cellular biology 17 (3), 1513-1521, 1997
2651997
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response
JN Winnay, J Boucher, MA Mori, K Ueki, CR Kahn
Nature medicine 16 (4), 438-445, 2010
1842010
Phosphorylation of C/EBPα inhibits granulopoiesis
SE Ross, HS Radomska, B Wu, P Zhang, JN Winnay, L Bajnok, ...
Molecular and cellular biology 24 (2), 675-686, 2004
1752004
Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2
A Assmann, K Ueki, JN Winnay, T Kadowaki, RN Kulkarni
Molecular and cellular biology 29 (11), 3219-3228, 2009
1492009
Specific roles of the p110α isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation
VR Sopasakis, P Liu, R Suzuki, T Kondo, J Winnay, TT Tran, T Asano, ...
Cell metabolism 11 (3), 220-230, 2010
1312010
Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice
RN Kulkarni, K Almind, HJ Goren, JN Winnay, K Ueki, T Okada, CR Kahn
Diabetes 52 (6), 1528-1534, 2003
1272003
The phosphoinositide 3-kinase regulatory subunit p85α can exert tumor suppressor properties through negative regulation of growth factor signaling
CM Taniguchi, J Winnay, T Kondo, RT Bronson, AR Guimaraes, ...
Cancer research 70 (13), 5305-5315, 2010
1242010
Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin α gene
BM Gummow, JN Winnay, GD Hammer
Journal of Biological Chemistry 278 (29), 26572-26579, 2003
1052003
A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.
F Mauvais-Jarvis, A Virkamaki, MD Michael, JN Winnay, A Zisman, ...
Diabetes 49 (12), 2126-2134, 2000
992000
Micro RNA‐455 regulates brown adipogenesis via a novel HIF 1an‐AMPK‐PGC 1α signaling network
H Zhang, M Guan, KL Townsend, TL Huang, D An, X Yan, R Xue, ...
EMBO reports 16 (10), 1378-1393, 2015
932015
SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling
KK Chudasama, J Winnay, S Johansson, T Claudi, R König, I Haldorsen, ...
The American Journal of Human Genetics 93 (1), 150-157, 2013
912013
Cross-talk between insulin and Wnt signaling in preadipocytes role of WNT co-receptor low density lipoprotein receptor-related protein-5 (LRP5)
J Palsgaard, B Emanuelli, JN Winnay, G Sumara, G Karsenty, CR Kahn
Journal of Biological Chemistry 287 (15), 12016-12026, 2012
822012
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