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Alicia Bloomfield
Alicia Bloomfield
Supervisor, Oncology Unit
E-mail confirmado em covance.com
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Preclinical evaluation of EC145, a folate-vinca alkaloid conjugate
JA Reddy, R Dorton, E Westrick, A Dawson, T Smith, LC Xu, M Vetzel, ...
Cancer research 67 (9), 4434-4442, 2007
2312007
Preclinical antitumor activity of a novel folate-targeted dual drug conjugate
CP Leamon, JA Reddy, IR Vlahov, E Westrick, A Dawson, R Dorton, ...
Molecular pharmaceutics 4 (5), 659-667, 2007
1442007
In vivo structural activity and optimization studies of folate− tubulysin conjugates
JA Reddy, R Dorton, A Dawson, M Vetzel, N Parker, JS Nicoson, ...
Molecular pharmaceutics 6 (5), 1518-1525, 2009
902009
Folate–vinca alkaloid conjugates for cancer therapy: A structure–activity relationship
CP Leamon, IR Vlahov, JA Reddy, M Vetzel, HKR Santhapuram, F You, ...
Bioconjugate chemistry 25 (3), 560-568, 2014
822014
Impact of high and low folate diets on tissue folate receptor levels and antitumor responses toward folate-drug conjugates
CP Leamon, JA Reddy, R Dorton, A Bloomfield, K Emsweller, N Parker, ...
Journal of Pharmacology and Experimental Therapeutics 327 (3), 918-925, 2008
822008
Reducing undesirable hepatic clearance of a tumor-targeted vinca alkaloid via novel saccharopeptidic modifications
CP Leamon, JA Reddy, PJ Klein, IR Vlahov, R Dorton, A Bloomfield, ...
Journal of Pharmacology and Experimental Therapeutics 336 (2), 336-343, 2011
632011
Pre-clinical evaluation of EC1456, a folate-tubulysin anti-cancer therapeutic
JA Reddy, R Dorton, A Bloomfield, M Nelson, C Dircksen, M Vetzel, ...
Scientific reports 8 (1), 8943, 2018
542018
Physical activity and bone health. Position stand of the American College of Sports Medicine
WM Kohrt, SA Bloomfield, KD Little, ME Nelson, VR Yingling
Med Sci Sports Exerc 36, 1985-1996, 2004
402004
Conjugates for treating diseases caused by PSMA expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent 9,636,413, 2017
342017
Rational combination therapy of vintafolide (EC145) with commonly used chemotherapeutic drugs
JA Reddy, R Dorton, A Bloomfield, M Nelson, M Vetzel, J Guan, ...
Clinical Cancer Research 20 (8), 2104-2114, 2014
322014
Conjugates for treating diseases caused by PSMA expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent 9,782,493, 2017
282017
Conjugates for treating diseases caused by psma expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent App. 15/245,508, 2016
272016
Conjugates for treating diseases caused by psma expressing cells
IR Vlahov, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
US Patent App. 15/245,512, 2016
272016
Prostate-specific membrane antigen-specific antitumor activity of a self-immolative tubulysin conjugate
CP Leamon, JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, ...
Bioconjugate Chemistry 30 (6), 1805-1813, 2019
262019
Strategy to prevent drug-related hypersensitivity in folate-targeted hapten immunotherapy of cancer
Y Lu, PJ Klein, E Westrick, LC Xu, HKR Santhapuram, A Bloomfield, ...
The AAPS journal 11, 628-638, 2009
242009
Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy
CP Leamon, JA Reddy, IR Vlahov, R Dorton, A Bloomfield, M Vetzel, ...
Cancer Chemotherapy and Pharmacology 79, 1151-1160, 2017
152017
High levels of expression of P-glycoprotein/multidrug resistance protein result in resistance to vintafolide
AD Guertin, J O'Neil, A Stoeck, JA Reddy, R Cristescu, BB Haines, ...
Molecular Cancer Therapeutics 15 (8), 1998-2008, 2016
142016
Pre-clinical development of EC1456: a potent folate targeted tubulysin SMDC
JA Reddy, A Bloomfield, M Nelson, R Dorton, M Vetzel, CP Leamon
Cancer research 74 (19_Supplement), 832-832, 2014
142014
ACSM Position Stand: physical activity and bone health. Medicine and Science adults: cross-sectional data from the Nakanojo Study
WM Kohrt, AS Bloomfield, KD Little, ME Nelson, VR Yngling
Osteoporos Int 18, 285-93, 2004
112004
PSMA-specific anti-tumor activity of the targeted-tubulysin conjugate, EC1169.
JA Reddy, A Bloomfield, R Dorton, M Nelson, M Vetzel, S Hahn, I Vlahov, ...
Cancer research 73 (8_Supplement), 2145-2145, 2013
92013
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