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Akshay Shekhar
Akshay Shekhar
Principal Scientist, Regeneron Pharmaceuticals
E-mail confirmado em regeneron.com
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An ex-ovo chicken embryo culture system suitable for imaging and microsurgery applications
HC Yalcin, A Shekhar, AA Rane, JT Butcher
JoVE (Journal of Visualized Experiments), e2154, 2010
912010
Hemodynamic patterning of the avian atrioventricular valve
HC Yalcin, A Shekhar, TC McQuinn, JT Butcher
Developmental Dynamics 240 (1), 23-35, 2011
832011
Scn1b deletion leads to increased tetrodotoxin‐sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts
X Lin, H O'Malley, C Chen, D Auerbach, M Foster, A Shekhar, M Zhang, ...
The Journal of physiology 593 (6), 1389-1407, 2015
742015
Transcription factor ETV1 is essential for rapid conduction in the heart
A Shekhar, X Lin, FY Liu, J Zhang, H Mo, L Bastarache, JC Denny, ...
The Journal of clinical investigation 126 (12), 4444-4459, 2016
602016
Computational fluid dynamics of developing avian outflow tract heart valves
KN Bharadwaj, C Spitz, A Shekhar, HC Yalcin, JT Butcher
Annals of biomedical engineering 40, 2212-2227, 2012
472012
PCP4 regulates Purkinje cell excitability and cardiac rhythmicity
EE Kim, A Shekhar, J Lu, X Lin, FY Liu, J Zhang, M Delmar, GI Fishman
The Journal of clinical investigation 124 (11), 5027-5036, 2014
462014
Growth and hemodynamics after early embryonic aortic arch occlusion
SE Lindsey, PG Menon, WJ Kowalski, A Shekhar, HC Yalcin, N Nishimura, ...
Biomechanics and modeling in mechanobiology 14, 735-751, 2015
412015
Fhf2 gene deletion causes temperature-sensitive cardiac conduction failure
DS Park, A Shekhar, C Marra, X Lin, C Vasquez, S Solinas, K Kelley, ...
Nature communications 7 (1), 12966, 2016
402016
Isolation and characterization of embryonic stem cell-derived cardiac Purkinje cells
K Maass, A Shekhar, J Lu, G Kang, F See, EE Kim, C Delgado, S Shen, ...
Stem Cells 33 (4), 1102-1112, 2015
402015
Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects
HC Yalcin, A Shekhar, N Nishimura, AA Rane, CB Schaffer, JT Butcher
American journal of physiology-Heart and circulatory physiology 299 (5 …, 2010
392010
Cardiac pressure overload decreases ETV1 expression in the left atrium, contributing to atrial electrical and structural remodeling
N Yamaguchi, J Xiao, D Narke, D Shaheen, X Lin, E Offerman, ...
Circulation 143 (8), 805-820, 2021
252021
ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes
A Shekhar, X Lin, B Lin, FY Liu, J Zhang, A Khodadadi-Jamayran, ...
Scientific reports 8 (1), 9944, 2018
252018
Effect of left atrial ligation-driven altered inflow hemodynamics on embryonic heart development: clues for prenatal progression of hypoplastic left heart syndrome
HE Salman, M Alser, A Shekhar, RA Gould, FM Benslimane, JT Butcher, ...
Biomechanics and Modeling in Mechanobiology 20, 733-750, 2021
232021
Early onset epilepsy and sudden unexpected death in epilepsy with cardiac arrhythmia in mice carrying the early infantile epileptic encephalopathy 47 gain‐of‐function FHF1 …
J Velíšková, C Marra, Y Liu, A Shekhar, DS Park, V Iatckova, Y Xie, ...
Epilepsia 62 (7), 1546-1558, 2021
152021
Generation of a tamoxifen inducible Tnnt2MerCreMer knock‐in mouse model for cardiac studies
J Yan, N Sultana, L Zhang, DS Park, A Shekhar, J Hu, L Bu, CL Cai
genesis 53 (6), 377-386, 2015
102015
A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction
J Yan, L Zhang, N Sultana, DS Park, A Shekhar, L Bu, J Hu, S Razzaque, ...
Plos one 10 (7), e0133472, 2015
72015
Ionic mechanisms of impulse propagation failure in the FHF2-deficient heart
DS Park, A Shekhar, J Santucci III, G Redel-Traub, S Solinas, S Mintz, ...
Circulation research 127 (12), 1536-1548, 2020
62020
Characterization of vortex flow in a mouse model of ventricular dyssynchrony by plane-wave ultrasound using hexplex processing
A Shekhar, O Aristizábal, GI Fishman, CKL Phoon, JA Ketterling
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 68 …, 2020
42020
Contrasting Ionic Mechanisms of Impaired Conduction in FHF1- and FHF2-Deficient Hearts
J Santucci III, DS Park, A Shekhar, X Lin, L Bu, N Yamaguchi, S Mintz, ...
Circulation: Arrhythmia and Electrophysiology 15 (8), e011296, 2022
32022
Activin a directly impairs human cardiomyocyte contractile function indicating a potential role in heart failure development
S MacDonnell, J Megna, Q Ruan, O Zhu, G Halasz, D Jasewicz, K Powers, ...
Frontiers in Cardiovascular Medicine 9, 1038114, 2022
22022
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