Karl Edman
Karl Edman
Associate Principal Scientist, Astrazeneca
E-mail confirmado em astrazeneca.com
Citado por
Citado por
High-resolution X-ray structure of an early intermediate in the bacteriorhodopsin photocycle
K Edman, P Nollert, A Royant, H Belrhali, E Pebay-Peyroula, J Hajdu, ...
Nature 401 (6755), 822-826, 1999
X-ray structure of sensory rhodopsin II at 2.1-Å resolution
A Royant, P Nollert, K Edman, R Neutze, EM Landau, E Pebay-Peyroula, ...
Proceedings of the National Academy of Sciences 98 (18), 10131-10136, 2001
Helix deformation is coupled to vectorial proton transport in the photocycle of bacteriorhodopsin
A Royant, K Edman, T Ursby, E Pebay-Peyroula, EM Landau, R Neutze
Nature 406 (6796), 645-648, 2000
Bacteriorhodopsin: a high-resolution structural view of vectorial proton transport
R Neutze, E Pebay-Peyroula, K Edman, A Royant, J Navarro, EM Landau
Biochimica Et Biophysica Acta (BBA)-Biomembranes 1565 (2), 144-167, 2002
Structural insight into allosteric modulation of protease-activated receptor 2
RKY Cheng, C Fiez-Vandal, O Schlenker, K Edman, B Aggeler, DG Brown, ...
Nature 545 (7652), 112-115, 2017
X-ray snapshots of serine protease catalysis reveal a tetrahedral intermediate
RC Wilmouth, K Edman, R Neutze, PA Wright, IJ Clifton, TR Schneider, ...
Nature structural biology 8 (8), 689-694, 2001
Analyzing protein functions in four dimensions
J Hajdu, R Neutze, T Sjögren, K Edman, A Szöke, RC Wilmouth, ...
Nature structural biology 7 (11), 1006-1012, 2000
Deformation of helix C in the low temperature L-intermediate of bacteriorhodopsin
K Edman, A Royant, G Larsson, F Jacobson, T Taylor, D van der Spoel, ...
Journal of Biological Chemistry 279 (3), 2147-2158, 2004
Ligand binding mechanism in steroid receptors: From conserved plasticity to differential evolutionary constraints
K Edman, A Hosseini, MK Bjursell, A Aagaard, L Wissler, A Gunnarsson, ...
Structure 23 (12), 2280-2290, 2015
Novel prostaglandin D synthase inhibitors generated by fragment-based drug design
M Hohwy, L Spadola, B Lundquist, P Hawtin, J Dahmén, I Groth-Clausen, ...
Journal of medicinal chemistry 51 (7), 2178-2186, 2008
Early structural rearrangements in the photocycle of an integral membrane sensory receptor
K Edman, A Royant, P Nollert, CA Maxwell, E Pebay-Peyroula, J Navarro, ...
Structure 10 (4), 473-482, 2002
Chemical Compounds 572
M Berger, J Dahmén, K Edman, A Eriksson, B Gabos, T Hansson, ...
US Patent App. 13/429,177, 2012
Cathepsin C inhibitors: property optimization and identification of a clinical candidate
M Furber, AK Tiden, P Gardiner, A Mete, R Ford, I Millichip, L Stein, ...
Journal of medicinal chemistry 57 (6), 2357-2367, 2014
Selective nonsteroidal glucocorticoid receptor modulators for the inhaled treatment of pulmonary diseases
M Hemmerling, S Nilsson, K Edman, S Eirefelt, W Russell, R Hendrickx, ...
Journal of medicinal chemistry 60 (20), 8591-8605, 2017
The discovery of MMP7 inhibitors exploiting a novel selectivity trigger
K Edman, M Furber, P Hemsley, C Johansson, G Pairaudeau, J Petersen, ...
ChemMedChem 6 (5), 769-773, 2011
Spectroscopic Characterization of Bacteriorhodopsin's L‐intermediate in 3D Crystals Cooled to 170 K¶
A Royant, K Edman, T Ursby, E Pebay‐Peyroula, EM Landau, R Neutze
Photochemistry and photobiology 74 (6), 794-804, 2001
Discovery of a novel oral glucocorticoid receptor modulator (AZD9567) with improved side effect profile
L Ripa, K Edman, M Dearman, G Edenro, R Hendrickx, V Ullah, ...
Journal of medicinal chemistry 61 (5), 1785-1799, 2018
Binding mode and induced fit predictions for prospective computational drug design
C Grebner, J Iegre, J Ulander, K Edman, A Hogner, C Tyrchan
Journal of chemical information and modeling 56 (4), 774-787, 2016
Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion
K Bamberg, U Johansson, K Edman, L William-Olsson, S Myhre, ...
PloS one 13 (2), e0193380, 2018
Discovery of 9-(1-phenoxyethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as oral PI3Kβ inhibitors, useful as antiplatelet agents
F Giordanetto, B Barlaam, S Berglund, K Edman, O Karlsson, J Lindberg, ...
Bioorganic & medicinal chemistry letters 24 (16), 3936-3943, 2014
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