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Daniel Alencar Rodrigues
Daniel Alencar Rodrigues
Royal College of Surgeons in Ireland
E-mail confirmado em rcsi.com - Página inicial
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Ru (II) compounds: next-generation anticancer metallotherapeutics?
S Thota, DA Rodrigues, DC Crans, EJ Barreiro
Journal of medicinal chemistry 61 (14), 5805-5821, 2018
4092018
N-Acylhydrazones as drugs
S Thota, DA Rodrigues, PSM Pinheiro, LM Lima, CAM Fraga, EJ Barreiro
Bioorganic & medicinal chemistry letters 28 (17), 2797-2806, 2018
1712018
Design, Synthesis, and Pharmacological Evaluation of Novel N-Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors
DA Rodrigues, GA Ferreira-Silva, ACS Ferreira, RA Fernandes, JK Kwee, ...
Journal of medicinal chemistry 59 (2), 655-670, 2016
1152016
Duvelisib: a 2018 novel FDA-approved small molecule inhibiting phosphoinositide 3-kinases
DA Rodrigues, FS Sagrillo, CAM Fraga
Pharmaceuticals 12 (2), 69, 2019
622019
Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities
DA Rodrigues, PSM Pinheiro, FS Sagrillo, ML Bolognesi, CAM Fraga
Medicinal research reviews 40 (6), 2177-2211, 2020
472020
Synthesis, characterization, DNA binding, DNA cleavage, protein binding and cytotoxic activities of Ru (II) complexes
S Thota, S Vallala, R Yerra, DA Rodrigues, NM Raghavendra, EJ Barreiro
International journal of biological macromolecules 82, 663-670, 2016
422016
Design, Synthesis, and Pharmacological Evaluation of First‐in‐Class Multitarget N‐Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors
DA Rodrigues, FS Guerra, FS Sagrillo, P de Sena M. Pinheiro, MA Alves, ...
ChemMedChem 15 (6), 539-551, 2020
372020
The use of conformational restriction in medicinal chemistry
P de Sena M Pinheiro, DA Rodrigues, R do Couto Maia, S Thota, ...
Current topics in medicinal chemistry 19 (19), 1712-1733, 2019
312019
Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol‐3‐kinase (PI3K): Current and future prospects
DA Rodrigues, PSM Pinheiro, CAM Fraga
ChemMedChem 16 (3), 448-457, 2021
182021
Beyond the selective inhibition of histone deacetylase 6
D A Rodrigues, S Thota, C AM Fraga
Mini Reviews in Medicinal Chemistry 16 (14), 1175-1184, 2016
182016
Theoretical and experimental characterization of 1, 4-N⋯ S σ-hole intramolecular interactions in bioactive N-acylhydrazone derivatives
PSM Pinheiro, DA Rodrigues, MA Alves, LW Tinoco, GB Ferreira, ...
New Journal of Chemistry 42 (1), 497-505, 2018
162018
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound
TF Gomes, TET Pompeu, DA Rodrigues, F Noël, R Menegatti, ...
European Journal of Medicinal Chemistry 62, 214-221, 2013
162013
Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40)
DA Rodrigues, PSM Pinheiro, TTSC Ferreira, S Thota, CAM Fraga
Chemical Biology & Drug Design 91 (3), 668-680, 2018
152018
Recent advances in development of polyphenols as anticancer agents
S Thota, DA Rodrigues, EJ Barreiro
Mini Reviews in Medicinal Chemistry 18 (15), 1265-1269, 2018
132018
An unusual intramolecular halogen bond guides conformational selection
R Tesch, C Becker, MP Müller, ME Beck, L Quambusch, M Getlik, ...
Angewandte Chemie International Edition 57 (31), 9970-9975, 2018
132018
The path to venetoclax resistance is paved with mutations, metabolism, and more
GP Sullivan, L Flanagan, DA Rodrigues, T Ní Chonghaile
Science Translational Medicine 14 (674), eabo6891, 2022
112022
Novel single inhibitor of HDAC6/8 and dual inhibitor of PI3K/HDAC6 as potential alternative treatments for prostate cancer
FS Guerra, DA Rodrigues, CAM Fraga, PD Fernandes
Pharmaceuticals 14 (5), 387, 2021
102021
Advances in the Design and Development of PROTAC-mediated HDAC Degradation
DA Rodrigues, A Roe, D Griffith, TN Chonghaile
Current Topics in Medicinal Chemistry 22 (5), 408-424, 2022
92022
Modeling zinc‐oxygen coordination in histone deacetylase: a comparison of semiempirical methods performance
PSM Pinheiro, DA Rodrigues, CMR Sant'Anna, CAM Fraga
International Journal of Quantum Chemistry 118 (21), e25720, 2018
62018
Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC
H Zhang, CS Nabel, D Li, RÍ O’Connor, CR Crosby, SM Chang, Y Hao, ...
Journal of Thoracic Oncology 18 (7), 882-895, 2023
42023
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