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Ron Diskin
Ron Diskin
Department of Chemical and Structural Biology Weizmann Institute of Science
E-mail confirmado em weizmann.ac.il
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Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
JF Scheid, H Mouquet, B Ueberheide, R Diskin, F Klein, TYK Oliveira, ...
Science 333 (6049), 1633-1637, 2011
13352011
Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization
F Klein, R Diskin, JF Scheid, C Gaebler, H Mouquet, IS Georgiev, ...
Cell 153 (1), 126-138, 2013
6212013
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
F Klein, A Halper-Stromberg, JA Horwitz, H Gruell, JF Scheid, ...
Nature 492 (7427), 118-122, 2012
5762012
Increasing the potency and breadth of an HIV antibody by using structure-based rational design
R Diskin, JF Scheid, PM Marcovecchio, AP West Jr, F Klein, H Gao, ...
Science 334 (6060), 1289-1293, 2011
4342011
Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients
C Kreer, M Zehner, T Weber, MS Ercanoglu, L Gieselmann, C Rohde, ...
Cell 182 (4), 843-854. e12, 2020
3692020
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
M Shingai, OK Donau, RJ Plishka, A Buckler-White, JR Mascola, ...
Journal of Experimental Medicine 211 (10), 2061-2074, 2014
3512014
Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120
AP West Jr, R Diskin, MC Nussenzweig, PJ Bjorkman
Proceedings of the National Academy of Sciences 109 (30), E2083-E2090, 2012
2552012
Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bNAbs
S Hoot, AT McGuire, KW Cohen, RK Strong, L Hangartner, F Klein, ...
PLoS pathogens 9 (1), e1003106, 2013
2232013
Structure of a clade C HIV-1 gp120 bound to CD4 and CD4-induced antibody reveals anti-CD4 polyreactivity
R Diskin, PM Marcovecchio, PJ Bjorkman
Nature structural & molecular biology 17 (5), 608-613, 2010
1322010
Polyclonal and convergent antibody response to Ebola virus vaccine rVSV-ZEBOV
SA Ehrhardt, M Zehner, V Krähling, H Cohen-Dvashi, C Kreer, N Elad, ...
Nature medicine 25 (10), 1589-1600, 2019
1052019
Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies
R Diskin, F Klein, JA Horwitz, A Halper-Stromberg, DN Sather, ...
Journal of Experimental Medicine 210 (6), 1235-1249, 2013
1042013
Optimizing antibody affinity and stability by the automated design of the variable light-heavy chain interfaces
S Warszawski, A Borenstein Katz, R Lipsh, L Khmelnitsky, G Ben Nissan, ...
PLoS computational biology 15 (8), e1007207, 2019
962019
Assembly mechanism of mucin and von Willebrand factor polymers
G Javitt, L Khmelnitsky, L Albert, LS Bigman, N Elad, D Morgenstern, ...
Cell 183 (3), 717-729. e16, 2020
922020
Molecular mechanism for LAMP1 recognition by Lassa virus
H Cohen-Dvashi, N Cohen, H Israeli, R Diskin
Journal of virology 89 (15), 7584-7592, 2015
912015
A mouse model for HIV-1 entry
J Pietzsch, H Gruell, S Bournazos, BM Donovan, F Klein, R Diskin, ...
Proceedings of the National Academy of Sciences 109 (39), 15859-15864, 2012
902012
Structures of p38α active mutants reveal conformational changes in L16 loop that induce autophosphorylation and activation
R Diskin, M Lebendiker, D Engelberg, O Livnah
Journal of molecular biology 365 (1), 66-76, 2007
872007
Active mutants of the human p38α mitogen-activated protein kinase
R Diskin, N Askari, R Capone, D Engelberg, O Livnah
Journal of Biological Chemistry 279 (45), 47040-47049, 2004
842004
Intrinsically active variants of all human p38 isoforms
M Avitzour, R Diskin, B Raboy, N Askari, D Engelberg, O Livnah
The FEBS journal 274 (4), 963-975, 2007
782007
Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody
L Scharf, AP West Jr, H Gao, T Lee, JF Scheid, MC Nussenzweig, ...
Proceedings of the National Academy of Sciences 110 (15), 6049-6054, 2013
752013
Role of LAMP1 binding and pH sensing by the spike complex of Lassa virus
H Cohen-Dvashi, H Israeli, O Shani, A Katz, R Diskin
Journal of virology 90 (22), 10329-10338, 2016
632016
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Artigos 1–20