Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy TN Chonghaile, KA Sarosiek, TT Vo, JA Ryan, A Tammareddi, ... Science 334 (6059), 1129-1133, 2011 | 631 | 2011 |
Bcl-2 family on guard at the ER E Szegezdi, DC MacDonald, T Ní Chonghaile, S Gupta, A Samali American Journal of Physiology-Cell Physiology 296 (5), C941-C953, 2009 | 320 | 2009 |
Mimicking the BH3 domain to kill cancer cells TN Chonghaile, A Letai Oncogene 27 (1), S149-S157, 2008 | 305 | 2008 |
Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199 TN Chonghaile, JE Roderick, C Glenfield, J Ryan, SE Sallan, ... Cancer discovery 4 (9), 1074-1087, 2014 | 269 | 2014 |
Mitochondria: gatekeepers of response to chemotherapy KA Sarosiek, TN Chonghaile, A Letai Trends in cell biology 23 (12), 612-619, 2013 | 183 | 2013 |
BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics C Touzeau, J Ryan, J Guerriero, P Moreau, TN Chonghaile, S Le Gouill, ... Leukemia 30 (3), 761-764, 2016 | 157 | 2016 |
MLL-rearranged acute lymphoblastic leukemias activate BCL-2 through H3K79 methylation and are sensitive to the BCL-2-specific antagonist ABT-199 JM Benito, L Godfrey, K Kojima, L Hogdal, M Wunderlich, H Geng, I Marzo, ... Cell reports 13 (12), 2715-2727, 2015 | 143 | 2015 |
P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment AK Azab, P Quang, F Azab, C Pitsillides, B Thompson, T Chonghaile, ... Blood, The Journal of the American Society of Hematology 119 (6), 1468-1478, 2012 | 131 | 2012 |
Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl‐xL JLV Reeve, E Szegezdi, SE Logue, TN Chonghaile, T O’Brien, T Ritter, ... Journal of cellular and molecular medicine 11 (3), 509-520, 2007 | 107 | 2007 |
Therapeutic rationale to target highly expressed CDK7 conferring poor outcomes in triple-negative breast cancer B Li, T Ni Chonghaile, Y Fan, SF Madden, R Klinger, AE O'Connor, ... Cancer research 77 (14), 3834-3845, 2017 | 94 | 2017 |
Targeting the miR-221–222/PUMA/BAK/BAX pathway abrogates dexamethasone resistance in multiple myeloma JJ Zhao, ZB Chu, Y Hu, J Lin, Z Wang, M Jiang, M Chen, X Wang, Y Kang, ... Cancer research 75 (20), 4384-4397, 2015 | 86 | 2015 |
Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts S Suryani, H Carol, TN Chonghaile, V Frismantas, C Sarmah, L High, ... Clinical cancer research 20 (17), 4520-4531, 2014 | 80 | 2014 |
The emerging role of non-traditional ubiquitination in oncogenic pathways L Dwane, WM Gallagher, TN Chonghaile, DP O'Connor Journal of Biological Chemistry 292 (9), 3543-3551, 2017 | 53 | 2017 |
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia IM Ariës, K Bodaar, SA Karim, TN Chonghaile, L Hinze, MA Burns, ... Journal of Experimental Medicine 215 (12), 3094-3114, 2018 | 49 | 2018 |
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer CM Dowling, KER Hollinshead, A Di Grande, J Pritchard, H Zhang, ... Science advances 7 (3), eabc4897, 2021 | 38 | 2021 |
Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-XL T Ní Chonghaile, CG Concannon, E Szegezdi, AM Gorman, A Samali Apoptosis 11, 1247-1255, 2006 | 37 | 2006 |
Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199. Cancer Discov. 2014; 4: 1074–1087. doi: 10.1158 … TN Chonghaile, JE Roderick, C Glenfield, J Ryan, SE Sallan, ... CD-14-0353.[Europe PMC free article][Abstract][CrossRef][Google Scholar], 2022 | 33 | 2022 |
The anti-inflammatory compound candesartan cilexetil improves neurological outcomes in a mouse model of neonatal hypoxia S Quinlan, P Merino-Serrais, A Di Grande, H Dussmann, JHM Prehn, ... Frontiers in Immunology 10, 1752, 2019 | 20 | 2019 |
A functional genomic screen identifies the deubiquitinase USP11 as a novel transcriptional regulator of ERα in breast cancer Cancer Research, 2020 | 18 | 2020 |
BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1 TN Chonghaile, S Gupta, M John, E Szegezdi, SE Logue, A Samali Biochemical and biophysical research communications 466 (1), 40-45, 2015 | 18 | 2015 |