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Kun Qian
Kun Qian
Researcher at Chemical Biology Consortium Sweden, Karolinska Institute-SciLifeLab
E-mail confirmado em ki.se
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Small molecule inhibitors of protein arginine methyltransferases
H Hu, K Qian, MC Ho, YG Zheng
Expert opinion on investigational drugs 25 (3), 335-358, 2016
1502016
Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing
L Zhang, NT Tran, H Su, R Wang, Y Lu, H Tang, S Aoyagi, A Guo, ...
Elife 4, e07938, 2015
1442015
Diamidine compounds for selective inhibition of protein arginine methyltransferase 1
L Yan, C Yan, K Qian, H Su, SA Kofsky-Wofford, WC Lee, X Zhao, MC Ho, ...
Journal of medicinal chemistry 57 (6), 2611-2622, 2014
882014
The dynamic conformational landscape of the protein methyltransferase SETD8
S Chen, RP Wiewiora, F Meng, N Babault, A Ma, W Yu, K Qian, H Hu, ...
Elife 8, e45403, 2019
422019
Protein arginine methyltransferase 1 is a novel regulator of MYCN in neuroblastoma
A Eberhardt, JN Hansen, J Koster, LT Lotta Jr, S Wang, E Livingstone, ...
Oncotarget 7 (39), 63629, 2016
232016
Downregulation of PRMT1 promotes the senescence and migration of a non-MYCN amplified neuroblastoma SK-N-SH cells
YJ Lee, WW Chang, CP Chang, TY Liu, CY Chuang, K Qian, YG Zheng, ...
Scientific reports 9 (1), 1771, 2019
212019
Discovery of decamidine as a new and potent PRMT1 inhibitor
J Zhang, K Qian, C Yan, M He, BA Jassim, I Ivanov, YG Zheng
MedChemComm 8 (2), 440-444, 2017
192017
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
X Mo, Q Niu, AA Ivanov, YH Tsang, C Tang, C Shu, Q Li, K Qian, ...
Cell 185 (11), 1974-1985. e12, 2022
172022
Detection of PRMT1 inhibitors with stopped flow fluorescence
K Qian, H Hu, H Xu, YG Zheng
Signal Transduction and Targeted Therapy 3 (1), 6, 2018
82018
Acquisition of taxane resistance by p53 inactivation in ovarian cancer cells
C Shu, X Zheng, A Wuhafu, D Cicka, S Doyle, Q Niu, D Fan, K Qian, ...
Acta Pharmacologica Sinica 43 (9), 2419-2428, 2022
72022
Discovery of the first chemical tools to regulate MKK3-mediated MYC activation in cancer
X Yang, D Fan, AH Troha, HM Ahn, K Qian, B Liang, Y Du, H Fu, ...
Bioorganic & medicinal chemistry 45, 116324, 2021
72021
Current development of protein arginine methyltransferase inhibitors
K Qian, YG Zheng
Epi-Informatics, 231-256, 2016
42016
Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases
K Qian, C Yan, H Su, T Dang, B Zhou, Z Wang, X Zhao, I Ivanov, MC Ho, ...
RSC Medicinal Chemistry 12 (1), 95-102, 2021
32021
Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease
Y Du, WJ Bradshaw, TM Leisner, JK Annor-Gyamfi, K Qian, FM Bashore, ...
Journal of Biological Chemistry 299 (12), 2023
12023
High Throughput Screening Methods for PPI Inhibitor Discovery
SP Doyle, X Mo, K Qian, DN Cicka, Q Niu, H Fu
Protein–Protein Interaction Regulators, 49-86, 2020
12020
Palladium brings proteins to life
K Qian, YG Zheng
Nature Chemical Biology 10 (5), 328-330, 2014
12014
TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS
D Cicka, Q Niu, M Qui, K Qian, E Miller, D Fan, X Mo, AA Ivanov, ...
Journal of Molecular Cell Biology 15 (3), mjad017, 2023
2023
Ultra High-Throughput Screening Assays for Inhibitors of TMPRSS2 and SPIKE Interaction
D Cicka, Q Niu, K Qian, D Fan, A Ivanov, S Sarafianos, Y Du, H Fu
Journal of Biological Chemistry, S152-S152, 2023
2023
Identification and characterization of isoform-selective inhibitors for protein arginine methyltransferases
K Qian
University of Georgia, 2017
2017
Development of isoform-selective protein arginine methyltransferase inhibitors
YG Zheng, I Ivanov, K Qian, C Yan
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 248, 2014
2014
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Artigos 1–20