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Line Ledsgaard
Line Ledsgaard
E-mail confirmado em bio.dtu.dk
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Basics of antibody phage display technology
L Ledsgaard, M Kilstrup, A Karatt-Vellatt, J McCafferty, AH Laustsen
Toxins 10 (6), 236, 2018
2382018
Pros and cons of different therapeutic antibody formats for recombinant antivenom development
AH Laustsen, JM Gutiérrez, C Knudsen, KH Johansen, ...
Toxicon 146, 151-175, 2018
1572018
History of envenoming therapy and current perspectives
MB Pucca, FA Cerni, R Janke, E Bermúdez-Méndez, L Ledsgaard, ...
Frontiers in immunology 10, 1598, 2019
1082019
Advances in antibody phage display technology
L Ledsgaard, A Ljungars, C Rimbault, CV Sørensen, T Tulika, J Wade, ...
Drug Discovery Today 27 (8), 2151-2169, 2022
762022
Engineering and design considerations for next-generation snakebite antivenoms
C Knudsen, L Ledsgaard, RI Dehli, S Ahmadi, CV Sørensen, AH Laustsen
Toxicon 167, 67-75, 2019
512019
An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies
S Ahmadi, MB Pucca, JA Jürgensen, R Janke, L Ledsgaard, EM Schoof, ...
Scientific Reports 10 (1), 10765, 2020
402020
Antibody cross-reactivity in antivenom research
L Ledsgaard, TP Jenkins, K Davidsen, KE Krause, A Martos-Esteban, ...
Toxins 10 (10), 393, 2018
402018
Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A2 and Cytotoxins
MB Pucca, S Ahmadi, FA Cerni, L Ledsgaard, CV Sørensen, ...
Frontiers in Pharmacology 11, 611, 2020
392020
Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes
L Ledsgaard, J Wade, TP Jenkins, K Boddum, I Oganesyan, JA Harrison, ...
Nature Communications 14 (1), 682, 2023
242023
In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom
L Ledsgaard, AH Laustsen, U Pus, J Wade, P Villar, K Boddum, P Slavny, ...
MAbs 14 (1), 2085536, 2022
232022
Cross-reactive SARS-CoV-2 neutralizing antibodies from deep mining of early patient responses
G Bullen, JD Galson, G Hall, P Villar, L Moreels, L Ledsgaard, G Mattiuzzo, ...
Frontiers in Immunology 12, 678570, 2021
202021
Generation of multivalent nanobody-based proteins with improved neutralization of long α-neurotoxins from elapid snakes
J Wade, C Rimbault, H Ali, L Ledsgaard, E Rivera-de-Torre, ...
Bioconjugate chemistry 33 (8), 1494-1504, 2022
142022
Discovery of a recombinant human monoclonal immunoglobulin G antibody against α-Latrotoxin from the mediterranean black widow spider (Latrodectus tredecimguttatus)
S Føns, L Ledsgaard, MV Nikolaev, AA Vassilevski, CV Sørensen, ...
Frontiers in Immunology 11, 587825, 2020
92020
An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules
RN Patel, RH Clare, L Ledsgaard, M Nys, J Kool, AH Laustsen, C Ulens, ...
Biochemical pharmacology 216, 115758, 2023
62023
Orally active bivalent VHH construct prevents proliferation of F4+ enterotoxigenic Escherichia coli in weaned piglets
BK Fiil, SW Thrane, M Pichler, T Kittilä, L Ledsgaard, S Ahmadi, ...
Iscience 25 (4), 2022
62022
Basics of antibody phage display technology. Toxins 10: 236
L Ledsgaard, M Kilstrup, A Karatt-Vellatt, J McCafferty, AH Laustsen
62018
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper
CV Sørensen, J Fernández, AC Adams, HHK Wildenauer, S Schoffelen, ...
Nature Communications 15 (1), 173, 2024
52024
Synthetic antibodies block receptor binding and current‐inhibiting effects of α‐cobratoxin from Naja kaouthia
S Miersch, G de la Rosa, R Friis, L Ledsgaard, K Boddum, AH Laustsen, ...
Protein Science 31 (5), e4296, 2022
52022
auf dem Keller U, Arantes EC, Calıskan F and Laustsen AH (2020) Unity Makes Strength: Exploring Intraspecies and Interspecies Toxin Synergism between Phospholipases A2 and …
MB Pucca, S Ahmadi, FA Cerni, L Ledsgaard, CV Sørensen, ...
Front. Pharmacol. 11: 611. doi: 10.3389/fphar, 2020
52020
Cross-reactivity trends when selecting scFv antibodies against snake toxins using a phage display-based cross-panning strategy
CV Sørensen, L Ledsgaard, HHK Wildenauer, CH Dahl, TW Ebersole, ...
Scientific Reports 13 (1), 10181, 2023
42023
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