A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases RC Coll, AAB Robertson, JJ Chae, SC Higgins, R Muñoz-Planillo, ... Nature medicine 21 (3), 248-255, 2015 | 2255 | 2015 |
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice JJ Fuster, S MacLauchlan, MA Zuriaga, MN Polackal, AC Ostriker, ... Science 355 (6327), 842-847, 2017 | 1127 | 2017 |
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice AR Mridha, A Wree, AAB Robertson, MM Yeh, CD Johnson, ... Journal of hepatology 66 (5), 1037-1046, 2017 | 843 | 2017 |
Human monocytes engage an alternative inflammasome pathway MM Gaidt, TS Ebert, D Chauhan, T Schmidt, JL Schmid-Burgk, F Rapino, ... Immunity 44 (4), 833-846, 2016 | 730 | 2016 |
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition RC Coll, JR Hill, CJ Day, A Zamoshnikova, D Boucher, NL Massey, ... Nature chemical biology 15 (6), 556-559, 2019 | 643 | 2019 |
Natural product and natural product derived drugs in clinical trials MS Butler, AAB Robertson, MA Cooper Natural product reports 31 (11), 1612-1661, 2014 | 625 | 2014 |
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice R Gordon, EA Albornoz, DC Christie, MR Langley, V Kumar, S Mantovani, ... Science translational medicine 10 (465), eaah4066, 2018 | 561 | 2018 |
T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells G Arbore, EE West, R Spolski, AAB Robertson, A Klos, C Rheinheimer, ... Science 352 (6292), aad1210, 2016 | 470 | 2016 |
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice C Dempsey, AR Araiz, KJ Bryson, O Finucane, C Larkin, EL Mills, ... Brain, behavior, and immunity 61, 306-316, 2017 | 442 | 2017 |
K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria CJ Groß, R Mishra, KS Schneider, G Médard, J Wettmarshausen, ... Immunity 45 (4), 761-773, 2016 | 415 | 2016 |
Role for NLRP3 inflammasome–mediated, IL-1β–dependent responses in severe, steroid-resistant asthma RY Kim, JW Pinkerton, AT Essilfie, AAB Robertson, KJ Baines, AC Brown, ... American journal of respiratory and critical care medicine 196 (3), 283-297, 2017 | 358 | 2017 |
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5 PJ Baker, D Boucher, D Bierschenk, C Tebartz, PG Whitney, DB D'Silva, ... European journal of immunology 45 (10), 2918-2926, 2015 | 348 | 2015 |
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome V Neudecker, M Haneklaus, O Jensen, L Khailova, JC Masterson, H Tye, ... Journal of Experimental Medicine 214 (6), 1737-1752, 2017 | 330 | 2017 |
The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction GPJ Van Hout, L Bosch, GHJM Ellenbroek, JJ De Haan, WW Van Solinge, ... European heart journal 38 (11), 828-836, 2017 | 322 | 2017 |
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype AA Basiorka, KL McGraw, EA Eksioglu, X Chen, J Johnson, L Zhang, ... Blood, The Journal of the American Society of Hematology 128 (25), 2960-2975, 2016 | 315 | 2016 |
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice AP Perera, R Fernando, T Shinde, R Gundamaraju, B Southam, SS Sohal, ... Scientific reports 8 (1), 8618, 2018 | 249 | 2018 |
Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension SM Krishnan, YH Ling, BM Huuskes, DM Ferens, N Saini, CT Chan, ... Cardiovascular Research 115 (4), 776-787, 2019 | 210 | 2019 |
Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition MD Tate, JDH Ong, JK Dowling, JL McAuley, AB Robertson, E Latz, ... Scientific reports 6 (1), 27912, 2016 | 193 | 2016 |
High‐performance liquid chromatographic separation of natural and synthetic desulphoglucosinolates and their chemical validation by UV, NMR and chemical ionisation‐MS methods G Kiddle, RN Bennett, NP Botting, NE Davidson, AAB Robertson, ... Phytochemical Analysis: An International Journal of Plant Chemical and …, 2001 | 188 | 2001 |
Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt‐induced hypertension in mice SM Krishnan, JK Dowling, YH Ling, H Diep, CT Chan, D Ferens, MM Kett, ... British journal of pharmacology 173 (4), 752-765, 2016 | 179 | 2016 |