Ronald D Gorham
Ronald D Gorham
University Medical Center Utrecht
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Electrostatic clustering and free energy calculations provide a foundation for protein design and optimization
RD Gorham, CA Kieslich, D Morikis
Annals of biomedical engineering 39 (4), 1252-1263, 2011
Staphylococcal immune evasion proteins: structure, function, and host adaptation
KJ Koymans, M Vrieling, RD Gorham, JAG van Strijp
Staphylococcus aureus, 441-489, 2015
Molecular dynamics in drug design: new generations of compstatin analogs
P Tamamis, A Lopez de Victoria, RD Gorham Jr, ML Bellows‐Peterson, ...
Chemical biology & drug design 79 (5), 703-718, 2012
Quantitative modeling of the alternative pathway of the complement system
N Zewde, RD Gorham Jr, A Dorado, D Morikis
PloS one 11 (3), e0152337, 2016
Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes
ETM Berends, RD Gorham, M Ruyken, JA Soppe, H Orhan, PC Aerts, ...
BMC biology 13 (1), 1-13, 2015
An evaluation of Poisson–Boltzmann electrostatic free energy calculations through comparison with experimental mutagenesis data
RD Gorham Jr, CA Kieslich, A Nichols, NU Sausman, M Foronda, ...
Biopolymers 95 (11), 746-754, 2011
Is the rigid-body assumption reasonable?: Insights into the effects of dynamics on the electrostatic analysis of barnase–barstar
CA Kieslich, RD Gorham Jr, D Morikis
Journal of Non-Crystalline Solids 357 (2), 707-716, 2011
Bacterial killing by complement requires membrane attack complex formation via surface‐bound C5 convertases
DAC Heesterbeek, BW Bardoel, ES Parsons, I Bennett, M Ruyken, ...
The EMBO journal 38 (4), e99852, 2019
A new generation of potent complement inhibitors of the compstatin family
A López de Victoria, RD Gorham Jr, ML Bellows‐Peterson, J Ling, DD Lo, ...
Chemical biology & drug design 77 (6), 431-440, 2011
Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures
RD Gorham Jr, DL Forest, P Tamamis, AL de Victoria, M Kraszni, ...
Experimental eye research 116, 96-108, 2013
Hybrid flagellin as a T cell independent vaccine scaffold
KM Bennett, RD Gorham, V Gusti, L Trinh, D Morikis, DD Lo
BMC biotechnology 15 (1), 1-12, 2015
Viral regulators of complement activation: structure, function and evolution
H Ojha, HS Panwar, RD Gorham Jr, D Morikis, A Sahu
Molecular Immunology 61 (2), 89-99, 2014
Functional characterization of alternative and classical pathway C3/C5 convertase activity and inhibition using purified models
SA Zwarthoff, E Berends, S Mol, M Ruyken, PC Aerts, M Józsi, ...
Frontiers in immunology 9, 1691, 2018
Let’s tie the knot: marriage of complement and adaptive immunity in pathogen evasion, for better or worse
KM Bennett, SHM Rooijakkers, RD Gorham Jr
Frontiers in microbiology 8, 89, 2017
Molecular analysis of the interaction between staphylococcal virulence factor Sbi-IV and complement C3d
RD Gorham Jr, W Rodriguez, D Morikis
Biophysical journal 106 (5), 1164-1173, 2014
New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics
RD Gorham Jr, DL Forest, GA Khoury, J Smadbeck, CN Beecher, ...
Journal of medicinal chemistry 58 (2), 814-826, 2015
Complement inhibition by Staphylococcus aureus: Electrostatics of C3d–Efbc and C3d–ehp association
RD Gorham, CA Kieslich, D Morikis
Cellular and Molecular Bioengineering 5 (1), 32-43, 2012
A theoretical view of the C3d: CR2 binding controversy
RR Mohan, RD Gorham Jr, D Morikis
Molecular immunology 64 (1), 112-122, 2015
The influence of TAP1 and TAP2 gene polymorphisms on TAP function and its inhibition by viral immune evasion proteins
P Praest, RD Luteijn, IGJ Brak-Boer, J Lanfermeijer, H Hoelen, L Ijgosse, ...
Molecular immunology 101, 55-64, 2018
Discovery of small molecules for fluorescent detection of complement activation product C3d
RD Gorham Jr, V Nuñez, JH Lin, SHM Rooijakkers, VI Vullev, D Morikis
Journal of medicinal chemistry 58 (24), 9535-9545, 2015
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