Karen J Gregory
Karen J Gregory
E-mail confirmado em monash.edu
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The Concise Guide to PHARMACOLOGY 2019/20: G protein‐coupled receptors
SPH Alexander, A Christopoulos, AP Davenport, E Kelly, A Mathie, ...
British journal of pharmacology 176, S21-S141, 2019
5342019
Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator
H Wu, C Wang, KJ Gregory, GW Han, HP Cho, Y Xia, CM Niswender, ...
Science 344 (6179), 58-64, 2014
5042014
The concise guide to pharmacology 2017/18: overview
SPH Alexander, E Kelly, NV Marrion, JA Peters, E Faccenda, SD Harding, ...
British journal of pharmacology 174, S1-S16, 2017
2532017
A Novel Mechanism of G Protein-coupled Receptor Functional Selectivity: MUSCARINIC PARTIAL AGONIST McN-A-343 AS A BITOPIC ORTHOSTERIC/ALLOSTERIC LIGAND∗
C Valant, KJ Gregory, NE Hall, PJ Scammells, MJ Lew, PM Sexton, ...
Journal of Biological Chemistry 283 (43), 29312-29321, 2008
1822008
Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands
VA Avlani, KJ Gregory, CJ Morton, MW Parker, PM Sexton, ...
Journal of Biological Chemistry 282 (35), 25677-25686, 2007
1682007
Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias
KJ Gregory, NE Hall, AB Tobin, PM Sexton, A Christopoulos
Journal of Biological Chemistry 285 (10), 7459-7474, 2010
1522010
Practical strategies and concepts in GPCR allosteric modulator discovery: recent advances with metabotropic glutamate receptors
CW Lindsley, KA Emmitte, CR Hopkins, TM Bridges, KJ Gregory, ...
Chemical reviews 116 (11), 6707-6741, 2016
1512016
Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential
KJ Gregory, EN Dong, J Meiler, PJ Conn
Neuropharmacology 60 (1), 66-81, 2011
1322011
Allosteric modulation of muscarinic acetylcholine receptors
KJ Gregory, PM Sexton, A Christopoulos
Current neuropharmacology 5 (3), 157-167, 2007
1292007
Characterization of serotonin 5‐HT2C receptor signaling to extracellular signal‐regulated kinases 1 and 2
TD Werry, KJ Gregory, PM Sexton, A Christopoulos
Journal of neurochemistry 93 (6), 1603-1615, 2005
1122005
Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS
S Yin, MJ Noetzel, KA Johnson, R Zamorano, N Jalan-Sakrikar, ...
Journal of Neuroscience 34 (1), 79-94, 2014
1052014
Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents
JM Rook, Z Xiang, X Lv, A Ghoshal, JW Dickerson, TM Bridges, ...
Neuron 86 (4), 1029-1040, 2015
1022015
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity
JM Rook, MJ Noetzel, WA Pouliot, TM Bridges, PN Vinson, HP Cho, ...
Biological psychiatry 73 (6), 501-509, 2013
932013
Probing the metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a “molecular switch” in PAM …
KJ Gregory, ED Nguyen, SD Reiff, EF Squire, SR Stauffer, CW Lindsley, ...
Molecular pharmacology 83 (5), 991-1006, 2013
742013
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling
MJ Noetzel, KJ Gregory, PN Vinson, JT Manka, SR Stauffer, CW Lindsley, ...
Molecular pharmacology 83 (4), 835-847, 2013
742013
A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling
MJ Noetzel, KJ Gregory, PN Vinson, JT Manka, SR Stauffer, CW Lindsley, ...
Molecular pharmacology 83 (4), 835-847, 2013
742013
Discovery of a Novel Chemical Class of mGlu5 Allosteric Ligands with Distinct Modes of Pharmacology
AS Hammond, AL Rodriguez, SD Townsend, CM Niswender, KJ Gregory, ...
ACS chemical neuroscience 1 (10), 702-716, 2010
742010
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships
KJ Gregory, MJ Noetzel, JM Rook, PN Vinson, SR Stauffer, AL Rodriguez, ...
Molecular pharmacology 82 (5), 860-875, 2012
692012
Investigating metabotropic glutamate receptor 5 allosteric modulator cooperativity, affinity, and agonism: enriching structure-function studies and structure-activity relationships
KJ Gregory, MJ Noetzel, JM Rook, PN Vinson, SR Stauffer, AL Rodriguez, ...
Molecular pharmacology 82 (5), 860-875, 2012
692012
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor
K Leach, KJ Gregory, I Kufareva, E Khajehali, AE Cook, R Abagyan, ...
Cell research 26 (5), 574-592, 2016
682016
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Artigos 1–20