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Sumith Kularatne
Sumith Kularatne
Executive VP of R&D, On Target Laboratories
E-mail confirmado em ontargetlabs.com - Página inicial
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Folate-targeted therapeutic and imaging agents for cancer
PS Low, SA Kularatne
Current opinion in chemical biology 13 (3), 256-262, 2009
7102009
Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand
SA Kularatne, K Wang, HKR Santhapuram, PS Low
Molecular pharmaceutics 6 (3), 780-789, 2009
2622009
Design, Synthesis, and Preclinical Evaluation of Prostate-Specific Membrane Antigen Targeted 99mTc-Radioimaging Agents
SA Kularatne, Z Zhou, J Yang, CB Post, PS Low
Molecular pharmaceutics 6 (3), 790-800, 2009
2312009
Synthesis and activity of a folate peptide camptothecin prodrug
WA Henne, DD Doorneweerd, AR Hilgenbrink, SA Kularatne, PS Low
Bioorganic & medicinal chemistry letters 16 (20), 5350-5355, 2006
2142006
Quantitation of circulating tumor cells in blood samples from ovarian and prostate cancer patients using tumor‐specific fluorescent ligands
W He, SA Kularatne, KR Kalli, FG Prendergast, RJ Amato, GG Klee, ...
International journal of cancer 123 (8), 1968-1973, 2008
1782008
CXCR4 expression in prostate cancer progenitor cells
A Dubrovska, J Elliott, RJ Salamone, GD Telegeev, AE Stakhovsky, ...
PloS one 7 (2), e31226, 2012
1742012
Synthesis and biological analysis of prostate-specific membrane antigen-targeted anticancer prodrugs
SA Kularatne, C Venkatesh, HKR Santhapuram, K Wang, B Vaitilingam, ...
Journal of medicinal chemistry 53 (21), 7767-7777, 2010
1662010
Targeting of nanoparticles: folate receptor
SA Kularatne, PS Low
Cancer Nanotechnology: Methods and Protocols, 249-265, 2010
1442010
Development of tumor-targeted near infrared probes for fluorescence guided surgery
LE Kelderhouse, V Chelvam, C Wayua, S Mahalingam, S Poh, ...
Bioconjugate chemistry 24 (6), 1075-1080, 2013
1092013
Psma binding ligand-linker conjugates and methods for using
PS Low, SA Kularatne
US Patent 9,193,763, 2015
108*2015
Ligand‐targeted delivery of small interfering RNAs to malignant cells and tissues
M Thomas, SA Kularatne, L Qi, P Kleindl, CP Leamon, MJ Hansen, ...
Annals of the New York Academy of Sciences 1175 (1), 32-39, 2009
962009
Evaluation of novel tumor-targeted near-infrared probe for fluorescence-guided surgery of cancer
SM Mahalingam, SA Kularatne, CH Myers, P Gagare, M Norshi, X Liu, ...
Journal of medicinal chemistry 61 (21), 9637-9646, 2018
882018
Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis
YYJ Gent, K Weijers, CFM Molthoff, AD Windhorst, MC Huisman, ...
Arthritis research & therapy 15, 1-11, 2013
792013
Comparison of folate receptor targeted optical contrast agents for intraoperative molecular imaging
E De Jesus, JJ Keating, SA Kularatne, J Jiang, R Judy, J Predina, S Nie, ...
International Journal of Molecular Imaging 2015, 2015
782015
A CXCR4‐Targeted Site‐Specific Antibody–Drug Conjugate
SA Kularatne, V Deshmukh, J Ma, V Tardif, RKV Lim, HM Pugh, Y Sun, ...
Angewandte Chemie International Edition 53 (44), 11863-11867, 2014
752014
Evaluation of novel prostate-specific membrane antigen-targeted near-infrared imaging agent for fluorescence-guided surgery of prostate cancer
SA Kularatne, M Thomas, CH Myers, P Gagare, AK Kanduluru, CJ Crian, ...
Clinical Cancer Research 25 (1), 177-187, 2019
642019
Identification of a folate receptor-targeted near-infrared molecular contrast agent to localize pulmonary adenocarcinomas
JD Predina, AD Newton, C Connolly, A Dunbar, M Baldassari, ...
Molecular Therapy 26 (2), 390-403, 2018
622018
Buried solvent determines both anion-binding selectivity and binding stoichiometry with hydrogen-bonding receptors
DH Burns, K Calderon-Kawasaki, S Kularatne
The Journal of Organic Chemistry 70 (7), 2803-2807, 2005
582005
Intraoperative molecular imaging combined with positron emission tomography improves surgical management of peripheral malignant pulmonary nodules
JD Predina, AD Newton, J Keating, EM Barbosa Jr, O Okusanya, L Xia, ...
Annals of surgery 266 (3), 479-488, 2017
562017
A folate receptor-α–specific ligand that targets cancer tissue and not sites of inflammation
B Vaitilingam, V Chelvam, SA Kularatne, S Poh, W Ayala-Lopez, PS Low
Journal of Nuclear Medicine 53 (7), 1127-1134, 2012
532012
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