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Lucas Villas Bôas Hoelz
Lucas Villas Bôas Hoelz
Pesquisador Farmanguinhos/Fiocruz - Professor IFRJ
Email confirmado em ifrj.edu.br
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The clinically approved antiviral drug sofosbuvir inhibits Zika virus replication
CQ Sacramento, GR de Melo, CS de Freitas, N Rocha, LVB Hoelz, ...
Scientific reports 7 (1), 40920, 2017
2112017
Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo
CS de Freitas, LM Higa, CQ Sacramento, AC Ferreira, PA Reis, ...
PLoS neglected tropical diseases 13 (1), e0007072, 2019
1022019
Beyond Members of the Flaviviridae Family, Sofosbuvir Also Inhibits Chikungunya Virus Replication
AC Ferreira, PA Reis, CS de Freitas, CQ Sacramento, L Villas Bôas Hoelz, ...
Antimicrobial agents and chemotherapy 63 (2), 10.1128/aac. 01389-18, 2019
872019
Evaluation of 7-arylaminopyrazolo [1, 5-a] pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors
LFSP Azeredo, JP Coutinho, VAP Jabor, PR Feliciano, MC Nonato, ...
European Journal of Medicinal Chemistry 126, 72-83, 2017
682017
In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19
CQ Sacramento, N Fintelman-Rodrigues, JR Temerozo, APD Da Silva, ...
Journal of Antimicrobial Chemotherapy 76 (7), 1874-1885, 2021
672021
Quantitative structure-activity relationships of antioxidant phenolic compounds.
LVB Hoelz, BAC Horta, JQ Araújo, MG Albuquerque, RB Alencastro, ...
592010
Plasmodium falciparum dihydroorotate dehydrogenase: a drug target against malaria
LVB Hoelz, FA Calil, MC Nonato, LCS Pinheiro, N Boechat
Future Medicinal Chemistry 10 (15), 1853-1874, 2018
482018
Pyrroles as privileged scaffolds in the search for new potential HIV inhibitors
MCAD Bianco, DILF Marinho, LVB Hoelz, MM Bastos, N Boechat
Pharmaceuticals 14 (9), 893, 2021
402021
The in vitro antiviral activity of the anti-hepatitis C virus (HCV) drugs daclatasvir and sofosbuvir against SARS-CoV-2
CQ Sacramento, N Fintelman-Rodrigues, JR Temerozo, ...
BioRxiv, 2020.06. 15.153411, 2020
352020
Structural and Functional Analysis of a Platelet-Activating Lysophosphatidylcholine of Trypanosoma cruzi
F Gazos-Lopes, MM Oliveira, LVB Hoelz, DP Vieira, AF Marques, ...
PLoS neglected tropical diseases 8 (8), e3077, 2014
342014
Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE)
JQ Araújo, MA de Brito, LVB Hoelz, RB de Alencastro, HC Castro, ...
European journal of medicinal chemistry 46 (1), 39-51, 2011
312011
Comparative study between the anti-P. falciparum activity of triazolopyrimidine, pyrazolopyrimidine and quinoline derivatives and the identification of new PfDHODH inhibitors
FF Silveira, JO de Souza, LVB Hoelz, VR Campos, VAP Jabor, ...
European Journal of Medicinal Chemistry 209, 112941, 2021
272021
The clinically approved antiviral drug sofosbuvir impairs Brazilian zika virus replication
CQ Sacramento, GR de Melo, N Rocha, LV Bôas Hoelz, M Mesquita, ...
BioRxiv, 061671, 2016
272016
Molecular dynamics simulations of the free and inhibitor-bound cruzain systems in aqueous solvent: insights on the inhibition mechanism in acidic pH
LVB Hoelz, VF Leal, CR Rodrigues, PG Pascutti, MG Albuquerque, ...
Journal of Biomolecular Structure and Dynamics 34 (9), 1969-1978, 2016
202016
New pyrazolopyrimidine derivatives as Leishmania amazonensis arginase inhibitors
LM Feitosa, ER da Silva, LVB Hoelz, DL Souza, JA Come, ...
Bioorganic & Medicinal Chemistry 27 (14), 3061-3069, 2019
192019
Quimioterapia antileishmania: uma revisão da literatura
MM Bastos, N Boechat, LVB Hoelz, AP de Oliveira
Revista virtual de Química 8 (6), 2072-2104, 2016
182016
Imatinib derivatives as inhibitors of K562 cells in chronic myeloid leukemia
LD Azevedo, MM Bastos, FC Vasconcelos, LVB Hoelz, FPS Junior, ...
Medicinal Chemistry Research 26, 2929-2941, 2017
172017
Solvent Free, Microwave Assisted Conversion of Aldehydes into Nitriles and Oximes in the Presence of NH2OH·HCl and TiO2
LVB Hoelz, BT Gonçalves, JC Barros, JFM da Silva
Molecules 15 (1), 94-99, 2009
172009
Kinetic resolution of (±)-1, 2-O-isopropylidene-3, 6-di-O-benzyl-myo-inositol by lipases: An experimental and theoretical study on the reaction of a key precursor of chiral …
ABC Simas, AAT da Silva, AG Cunha, RS Assumpção, LVB Hoelz, ...
Journal of Molecular Catalysis B: Enzymatic 70 (1-2), 32-40, 2011
162011
Synthesis, biological evaluation, and molecular modeling studies of new thiadiazole derivatives as potent P2X7 receptor inhibitors
DTG Gonzaga, FH Oliveira, NL Ranke, GQ Pinho, JP Salles, ML Bello, ...
Frontiers in Chemistry 7, 261, 2019
152019
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