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Nikolaos Nikolaou
Nikolaos Nikolaou
Head of Research & Development
E-mail confirmado em definigen.com
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Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle
JK Dowman, LJ Hopkins, GM Reynolds, N Nikolaou, MJ Armstrong, ...
The American journal of pathology 184 (5), 1550-1561, 2014
1312014
Loss of 5α-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice
JK Dowman, LJ Hopkins, GM Reynolds, MJ Armstrong, M Nasiri, ...
Endocrinology 154 (12), 4536-4547, 2013
912013
Dual-5α-reductase inhibition promotes hepatic lipid accumulation in man
JM Hazlehurst, AI Oprescu, N Nikolaou, R Di Guida, AEK Grinbergs, ...
The Journal of Clinical Endocrinology & Metabolism 101 (1), 103-113, 2016
732016
Modified-release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia
CM Jones, A Mallappa, N Reisch, N Nikolaou, N Krone, BA Hughes, ...
The Journal of Clinical Endocrinology & Metabolism 102 (6), 1797-1806, 2017
652017
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
N Nikolaou, LL Gathercole, L Marchand, S Althari, NJ Dempster, ...
Metabolism 99, 67-80, 2019
592019
5α-Reductase type 2 regulates glucocorticoid action and metabolic phenotype in human hepatocytes
M Nasiri, N Nikolaou, S Parajes, NP Krone, G Valsamakis, G Mastorakos, ...
Endocrinology 156 (8), 2863-2871, 2015
472015
Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO)
N Nikolaou, CJ Green, PJ Gunn, L Hodson, JW Tomlinson
Physiological reports 4 (21), e12944, 2016
422016
The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1
L Barnard, N Nikolaou, C Louw, L Schiffer, H Gibson, LC Gilligan, ...
The Journal of steroid biochemistry and molecular biology 202, 105724, 2020
182020
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
N Nikolaou, LL Gathercole, L Kirkwood, JE Dunford, BA Hughes, ...
The Journal of steroid biochemistry and molecular biology 189, 218-227, 2019
182019
11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial
N Othonos, R Pofi, A Arvaniti, S White, I Bonaventura, N Nikolaou, ...
Nature Communications 14 (1), 1025, 2023
102023
The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies
N Nikolaou, L Hodson, JW Tomlinson
The Journal of Steroid Biochemistry and Molecular Biology 207, 105808, 2021
102021
Co-administration of 5α-reductase inhibitors worsens the adverse metabolic effects of prescribed glucocorticoids
N Othonos, T Marjot, C Woods, JM Hazlehurst, N Nikolaou, R Pofi, ...
The Journal of Clinical Endocrinology & Metabolism 105 (9), e3316-e3328, 2020
92020
Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents
JM Hazlehurst, TR Lim, C Charlton, JJ Miller, LL Gathercole, T Cornfield, ...
Metabolism open 14, 100177, 2022
82022
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo
N Nikolaou, A Arvaniti, N Appanna, A Sharp, BA Hughes, D Digweed, ...
Journal of Endocrinology 245 (2), 207-218, 2020
82020
AKR1D1 knockout mice develop a sex-dependent metabolic phenotype
LL Gathercole, N Nikolaou, SE Harris, A Arvaniti, TM Poolman, ...
Journal of Endocrinology 253 (3), 97-113, 2022
72022
Differential activity and expression of human 5β-reductase (AKR1D1) splice variants
N Appanna, H Gibson, E Gangitano, NJ Dempster, K Morris, S George, ...
Journal of molecular endocrinology 66 (3), 181-194, 2021
42021
Gender specific metabolic phenotype in the 5 [beta]-reductase knockout mouse
L Gathercole, P Klusonova, N Nikolaou, J Hazlehurst, A Moolla, ...
Endocrine Abstracts 49, 2017
32017
AKR1D1 knockdown identifies 7 [alpha]-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) as a driver of metabolic dysfunction and hepatocellular cancer risk in patients with non …
N Nikolaou, A Arvaniti, F Sanna, N Dempster, L Gathercole, J Tomlinson
Endocrine abstracts 81, 2022
12022
The american lifestyle induced obesity syndrome (ALIOS) diet induces an increase in intestinal permeability and exacerbates inflammation in female and male mice via the TLR4 …
A Anastasia, N Nikolaou, S Harris, R Cox, D Corridoni, W Xin, ...
Endocrine Abstracts 73, 2021
12021
Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males
LL Gathercole, N Nikolaou, A Arvaniti, SE Harris, TM Poolman, ...
bioRxiv, 2021.02. 02.429227, 2021
12021
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Artigos 1–20