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JH Ledo
JH Ledo
E-mail confirmado em musc.edu
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Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers
CP Figueiredo, JR Clarke, JH Ledo, FC Ribeiro, CV Costa, HM Melo, ...
Journal of Neuroscience 33 (23), 9626-9634, 2013
2032013
Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation
JR Clarke, NM Lyra e Silva, CP Figueiredo, RL Frozza, JH Ledo, ...
EMBO molecular medicine 7 (2), 190-210, 2015
1992015
Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice
JH Ledo, EP Azevedo, JR Clarke, FC Ribeiro, CP Figueiredo, D Foguel, ...
Molecular psychiatry 18 (10), 1053-1054, 2013
1612013
Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer's amyloid-β oligomers in mice
JH Ledo, EP Azevedo, D Beckman, FC Ribeiro, LE Santos, DS Razolli, ...
Journal of Neuroscience 36 (48), 12106-12116, 2016
1252016
Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α
HM Melo, GSS da Silva, MR Sant’Ana, CVL Teixeira, JR Clarke, ...
Cell Reports 30 (7), 2180-2194. e8, 2020
882020
Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice
J Brito-Moreira, MV Lourenco, MM Oliveira, FC Ribeiro, JH Ledo, LP Diniz, ...
Journal of Biological Chemistry 292 (18), 7327-7337, 2017
872017
Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis
EP Azevedo, JH Ledo, G Barbosa, M Sobrinho, L Diniz, ACC Fonseca, ...
Cell death & disease 4 (9), e789-e789, 2013
682013
Prion protein modulates monoaminergic systems and depressive-like behavior in mice
D Beckman, LE Santos, TA Americo, JH Ledo, FG de Mello, R Linden
Journal of Biological Chemistry 290 (33), 20488-20498, 2015
312015
Targeting Alzheimer's Pathology through PPARγ Signaling: Modulation of Microglial Function
MV Lourenco, JH Ledo
The Journal of Neuroscience 33 (12), 5083-5084, 2013
262013
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia
JH Ledo, T Liebmann, R Zhang, JC Chang, EP Azevedo, E Wong, ...
Molecular psychiatry 26 (10), 5620-5635, 2021
252021
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development
JH Ledo, R Zhang, L Mesin, D Mourão-Sá, EP Azevedo, OG Troyanskaya, ...
PloS one 15 (8), e0237773, 2020
102020
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015; 7: 190–210
JR Clarke, LES NM, CP Figueiredo, RL Frozza, JH Ledo, D Beckman, ...
External Resources Pubmed/Medline (NLM) Crossref (DOI), 0
7
Reply to altered monoaminergic systems and depressive-like behavior in congenic prion protein knock-out mice
D Beckman, LE Santos, TA Americo, JH Ledo, FG de Mello, R Linden
J Biol Chem 290, 26351, 2015
52015
Correction: Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice
JH Ledo, EP Azevedo, JR Clarke, FC Ribeiro, CP Figueiredo, D Foguel, ...
Molecular Psychiatry 26 (10), 6100-6101, 2021
42021
Amyloidogenic and anti-amyloidogenic properties of presenilin 1
V Bustos, MV Pulina, J Ledo
Advances in Pharmacology 90, 239-251, 2021
42021
Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress
DL Bhatti, L Medrihan, MX Chen, J Jin, KA McCabe, W Wang, ...
Frontiers in Molecular Neuroscience 15, 898851, 2022
32022
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains
A Millet, JH Ledo, SF Tavazoie
Immunity 57 (1), 153-170. e6, 2024
22024
Perfeccionismo e actividade física em adolescentes
M Pinto, J Vasconcelos-Raposo, A Almeida, I Claro, J Ledo, M Marques, ...
PsychTech & Health Journal 3 (2), 2020
12020
Interaction of Aβ oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice
J Brito-Moreira, MV Lourenco, MM Oliveira, JFS Vital, FC Ribeiro, ...
Journal of Biological Chemistry 292, 2017
12017
O3–02–03: Differential impact of high and low molecular mass beta‐amyloid oligomers on synapse density, receptor composition and memory in mice
S Ferreira, C Figueiredo, J Clarke, F Ribeiro, A Mota‐Sales, J Ledo, ...
Alzheimer's & Dementia 9, P520-P520, 2013
12013
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