Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers CP Figueiredo, JR Clarke, JH Ledo, FC Ribeiro, CV Costa, HM Melo, ... Journal of Neuroscience 33 (23), 9626-9634, 2013 | 203 | 2013 |
Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation JR Clarke, NM Lyra e Silva, CP Figueiredo, RL Frozza, JH Ledo, ... EMBO molecular medicine 7 (2), 190-210, 2015 | 199 | 2015 |
Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice JH Ledo, EP Azevedo, JR Clarke, FC Ribeiro, CP Figueiredo, D Foguel, ... Molecular psychiatry 18 (10), 1053-1054, 2013 | 161 | 2013 |
Cross talk between brain innate immunity and serotonin signaling underlies depressive-like behavior induced by Alzheimer's amyloid-β oligomers in mice JH Ledo, EP Azevedo, D Beckman, FC Ribeiro, LE Santos, DS Razolli, ... Journal of Neuroscience 36 (48), 12106-12116, 2016 | 125 | 2016 |
Palmitate is increased in the cerebrospinal fluid of humans with obesity and induces memory impairment in mice via pro-inflammatory TNF-α HM Melo, GSS da Silva, MR Sant’Ana, CVL Teixeira, JR Clarke, ... Cell Reports 30 (7), 2180-2194. e8, 2020 | 88 | 2020 |
Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice J Brito-Moreira, MV Lourenco, MM Oliveira, FC Ribeiro, JH Ledo, LP Diniz, ... Journal of Biological Chemistry 292 (18), 7327-7337, 2017 | 87 | 2017 |
Activated microglia mediate synapse loss and short-term memory deficits in a mouse model of transthyretin-related oculoleptomeningeal amyloidosis EP Azevedo, JH Ledo, G Barbosa, M Sobrinho, L Diniz, ACC Fonseca, ... Cell death & disease 4 (9), e789-e789, 2013 | 68 | 2013 |
Prion protein modulates monoaminergic systems and depressive-like behavior in mice D Beckman, LE Santos, TA Americo, JH Ledo, FG de Mello, R Linden Journal of Biological Chemistry 290 (33), 20488-20498, 2015 | 31 | 2015 |
Targeting Alzheimer's Pathology through PPARγ Signaling: Modulation of Microglial Function MV Lourenco, JH Ledo The Journal of Neuroscience 33 (12), 5083-5084, 2013 | 26 | 2013 |
Presenilin 1 phosphorylation regulates amyloid-β degradation by microglia JH Ledo, T Liebmann, R Zhang, JC Chang, EP Azevedo, E Wong, ... Molecular psychiatry 26 (10), 5620-5635, 2021 | 25 | 2021 |
Lack of a site-specific phosphorylation of Presenilin 1 disrupts microglial gene networks and progenitors during development JH Ledo, R Zhang, L Mesin, D Mourão-Sá, EP Azevedo, OG Troyanskaya, ... PloS one 15 (8), e0237773, 2020 | 10 | 2020 |
Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015; 7: 190–210 JR Clarke, LES NM, CP Figueiredo, RL Frozza, JH Ledo, D Beckman, ... External Resources Pubmed/Medline (NLM) Crossref (DOI), 0 | 7 | |
Reply to altered monoaminergic systems and depressive-like behavior in congenic prion protein knock-out mice D Beckman, LE Santos, TA Americo, JH Ledo, FG de Mello, R Linden J Biol Chem 290, 26351, 2015 | 5 | 2015 |
Correction: Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice JH Ledo, EP Azevedo, JR Clarke, FC Ribeiro, CP Figueiredo, D Foguel, ... Molecular Psychiatry 26 (10), 6100-6101, 2021 | 4 | 2021 |
Amyloidogenic and anti-amyloidogenic properties of presenilin 1 V Bustos, MV Pulina, J Ledo Advances in Pharmacology 90, 239-251, 2021 | 4 | 2021 |
Molecular and cellular adaptations in hippocampal parvalbumin neurons mediate behavioral responses to chronic social stress DL Bhatti, L Medrihan, MX Chen, J Jin, KA McCabe, W Wang, ... Frontiers in Molecular Neuroscience 15, 898851, 2022 | 3 | 2022 |
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains A Millet, JH Ledo, SF Tavazoie Immunity 57 (1), 153-170. e6, 2024 | 2 | 2024 |
Perfeccionismo e actividade física em adolescentes M Pinto, J Vasconcelos-Raposo, A Almeida, I Claro, J Ledo, M Marques, ... PsychTech & Health Journal 3 (2), 2020 | 1 | 2020 |
Interaction of Aβ oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice J Brito-Moreira, MV Lourenco, MM Oliveira, JFS Vital, FC Ribeiro, ... Journal of Biological Chemistry 292, 2017 | 1 | 2017 |
O3–02–03: Differential impact of high and low molecular mass beta‐amyloid oligomers on synapse density, receptor composition and memory in mice S Ferreira, C Figueiredo, J Clarke, F Ribeiro, A Mota‐Sales, J Ledo, ... Alzheimer's & Dementia 9, P520-P520, 2013 | 1 | 2013 |