| Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction LW Koblan, JL Doman, C Wilson, JM Levy, T Tay, GA Newby, JP Maianti, ... Nature biotechnology 36 (9), 843-846, 2018 | 772 | 2018 |
| Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones JP Maianti, A McFedries, ZH Foda, RE Kleiner, XQ Du, MA Leissring, ... Nature 511 (7507), 94-98, 2014 | 270 | 2014 |
| Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules DL Usanov, AI Chan, JP Maianti, DR Liu Nature chemistry 10 (7), 704-714, 2018 | 157 | 2018 |
| Editing of CCR5 receptor gene to protect against HIV infection JP Maianti, DR Liu US Patent 10,745,677, 2020 | 43 | 2020 |
| Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme JP Maianti, GA Tan, A Vetere, AJ Welsh, BK Wagner, MA Seeliger, DR Liu Nature chemical biology 15 (6), 565-574, 2019 | 41 | 2019 |
| Gene editing of pcsk9 JP Maianti, DR Liu US Patent App. 15/852,526, 2018 | 41 | 2018 |
| Incorporation of unnatural amino acids into proteins using base editing JP Maianti, DR Liu, LW Koblan US Patent 11,542,509, 2023 | 29 | 2023 |
| Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof DR Liu, JP Maianti, A Saghatelian, RE Kleiner US Patent 9,243,038, 2016 | 28 | 2016 |
| Hybrid Aminoglycoside Antibiotics via Tsuji Palladium-Catalyzed Allylic Deoxygenation S Hanessian, JP Maianti, RD Matias, LA Feeney, ES Armstrong Organic letters 13 (24), 6476-6479, 2011 | 28 | 2011 |
| Synthesis and Comparative Antibacterial Activity of Verdamicin C2 and C2a. A New Oxidation of Primary Allylic Azides in Dihydro[2H]pyrans S Hanessian, J Szychowski, JP Maianti Organic letters 11 (2), 429-432, 2009 | 28 | 2009 |
| Editing of CCR2 receptor gene to protect against HIV infection JP Maianti, DR Liu US Patent 11,820,969, 2023 | 23 | 2023 |
| Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4′-deoxy-4′-fluoro neomycin analogs S Hanessian, OM Saavedra, MA Vilchis-Reyes, JP Maianti, H Kanazawa, ... Chemical Science 5 (12), 4621-4632, 2014 | 23 | 2014 |
| Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs JP Maianti, H Kanazawa, P Dozzo, RD Matias, LA Feeney, ES Armstrong, ... ACS chemical biology 9 (9), 2067-2073, 2014 | 22 | 2014 |
| Toward Overcoming Staphylococcus aureus Aminoglycoside Resistance Mechanisms with a Functionally Designed Neomycin Analogue S Hanessian, A Giguere, J Grzyb, JP Maianti, OM Saavedra, JB Aggen, ... ACS Medicinal Chemistry Letters 2 (12), 924-928, 2011 | 22 | 2011 |
| Antibacterial aminoglycoside analogs JB Aggen, AA Goldblum, DJ Hildebrandt, TR Kane, P Dozzo, MJ Gliedt, ... US Patent 8,399,419, 2013 | 21 | 2013 |
| Suppression of pain by gene editing JP Maianti, DR Liu US Patent 11,898,179, 2024 | 19 | 2024 |
| The fungicide Mancozeb induces metacaspase-dependent apoptotic cell death in Saccharomyces cerevisiae BY4741 FJ Scariot, LM Jahn, JP Maianti, APL Delamare, S Echeverrigaray Apoptosis 21, 866-872, 2016 | 19 | 2016 |
| Cancer vaccine JP Maianti, DR Liu US Patent App. 16/492,534, 2021 | 18 | 2021 |
| Macrocyclic insulin-degrading enzyme (IDE) inhibitors and uses thereof DR Liu, JP Maianti, A Saghatelian, RE Kleiner US Patent 9,610,322, 2017 | 18 | 2017 |
| Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes JP Maianti, S Hanessian MedChemComm 7 (1), 170-176, 2016 | 17 | 2016 |
