Illuminating the mechanistic roles of enzyme conformational dynamics JA Hanson, K Duderstadt, LP Watkins, S Bhattacharyya, J Brokaw, ... Proceedings of the National Academy of Sciences 104 (46), 18055-18060, 2007 | 316 | 2007 |
A simplified and robust protocol for immunoglobulin expression in Escherichia coli cell‐free protein synthesis systems Q Cai, JA Hanson, AR Steiner, C Tran, MR Masikat, R Chen, JF Zawada, ... Biotechnology progress 31 (3), 823-831, 2015 | 95 | 2015 |
Engagement of arginine finger to ATP triggers large conformational changes in NtrC1 AAA+ ATPase for remodeling bacterial RNA polymerase B Chen, TA Sysoeva, S Chowdhury, L Guo, S De Carlo, JA Hanson, ... Structure 18 (11), 1420-1430, 2010 | 76 | 2010 |
RAMPED-UP NMR: multiplexed NMR-based screening for drug discovery ER Zartler, J Hanson, BE Jones, AD Kline, G Martin, H Mo, MJ Shapiro, ... Journal of the American Chemical Society 125 (36), 10941-10946, 2003 | 61 | 2003 |
Targeting CD74 in multiple myeloma with the novel, site-specific antibody-drug conjugate STRO-001 CL Abrahams, X Li, M Embry, A Yu, S Krimm, S Krueger, NY Greenland, ... Oncotarget 9 (102), 37700, 2018 | 48 | 2018 |
Dynamic Active-Site Protection by the M. tuberculosis Protein Tyrosine Phosphatase PtpB Lid Domain EM Flynn, JA Hanson, T Alber, H Yang Journal of the American Chemical Society 132 (13), 4772-4780, 2010 | 35 | 2010 |
Direct Mg2+ binding activates adenylate kinase from Escherichia coli YW Tan, JA Hanson, H Yang Journal of biological chemistry 284 (5), 3306-3313, 2009 | 34 | 2009 |
Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents J Almaliti, B Miller, H Pietraszkiewicz, E Glukhov, CB Naman, T Kline, ... European journal of medicinal chemistry 161, 416-432, 2019 | 24 | 2019 |
High frequency of CD74 expression in lymphomas: implications for targeted therapy using a novel anti‐CD74‐drug conjugate S Zhao, A Molina, A Yu, J Hanson, H Cheung, X Li, Y Natkunam The Journal of Pathology: Clinical Research 5 (1), 12-24, 2019 | 20 | 2019 |
Toward a ferrous iron-cleavable linker for antibody–drug conjugates B Spangler, T Kline, J Hanson, X Li, S Zhou, JA Wells, AK Sato, ... Molecular pharmaceutics 15 (5), 2054-2059, 2018 | 19 | 2018 |
Structural distributions from single-molecule measurements as a tool for molecular mechanics JA Hanson, J Brokaw, CC Hayden, JW Chu, H Yang Chemical physics 396, 61-71, 2012 | 19 | 2012 |
Confocal single-molecule FRET for protein conformational dynamics YW Tan, JA Hanson, JW Chu, H Yang Protein Dynamics: Methods and Protocols, 51-62, 2014 | 15 | 2014 |
Discovery of STRO-002, a novel homogeneous ADC targeting folate receptor alpha, for the treatment of ovarian and endometrial cancers X Li, S Zhou, CL Abrahams, S Krimm, J Smith, K Bajjuri, HT Stephenson, ... Molecular Cancer Therapeutics 22 (2), 155-167, 2023 | 14 | 2023 |
Development of an E. coli strain for cell‐free ADC manufacturing D Groff, NA Carlos, R Chen, JA Hanson, S Liang, S Armstrong, X Li, ... Biotechnology and Bioengineering 119 (1), 162-175, 2022 | 12 | 2022 |
Discovery and activity of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer X Li, C Abrahams, S Zhou, S Krimm, R Henningsen, H Stephenson, ... Cancer Res 78 (13 Supplement), 1782, 2018 | 12 | 2018 |
Abstract NT-090: Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian and endometrial cancer C Abrahams, S Krimm, X Li, S Zhou, J Hanson, MR Masikat, K Bajjuri, ... Clinical Cancer Research 25 (22_Supplement), NT-090-NT-090, 2019 | 7 | 2019 |
An integrated in vivo/in vitro protein production platform for site-specific antibody drug conjugates J Hanson, D Groff, A Carlos, H Usman, K Fong, A Yu, S Armstrong, ... Bioengineering 10 (3), 304, 2023 | 2 | 2023 |
Synthetic pathways for biofuel synthesis MCY Chang, B Bond-Watts, M Wen, JA Hanson US Patent App. 13/708,824, 2014 | 2 | 2014 |
Preclinical activity and safety of STRO-002, a novel ADC targeting folate receptor alpha for ovarian cancer V De Almeida, C Abrahams, W Solis, X Li, T Kline, J Hanson, MR Masikat, ... Gynecologic Oncology 149, 50, 2018 | 1 | 2018 |
Quantitative in vitro Biochemistry, one molecule at a time JA Hanson, H Yang Quantitative Biology, 111-130, 2012 | 1 | 2012 |