Douglas Golenbock
Douglas Golenbock
E-mail confirmado em umassmed.edu
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Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various …
S Sakaguchi, N Sakaguchi, M Asano, M Itoh, M Toda
The Journal of Immunology 155 (3), 1151-1164, 1995
80851995
IKKε and TBK1 are essential components of the IRF3 signaling pathway
KA Fitzgerald, SM McWhirter, KL Faia, DC Rowe, E Latz, DT Golenbock, ...
Nature immunology 4 (5), 491-496, 2003
25442003
Neuroinflammation in Alzheimer's disease
MT Heneka, MJ Carson, J El Khoury, GE Landreth, F Brosseron, ...
The Lancet Neurology 14 (4), 388-405, 2015
24032015
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
JC Chow, DW Young, DT Golenbock, WJ Christ, F Gusovsky
Journal of Biological Chemistry 274 (16), 10689-10692, 1999
21781999
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
EA Kurt-Jones, L Popova, L Kwinn, LM Haynes, LP Jones, RA Tripp, ...
Nature immunology 1 (5), 398-401, 2000
19172000
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
A Halle, V Hornung, GC Petzold, CR Stewart, BG Monks, T Reinheckel, ...
Nature immunology 9 (8), 857, 2008
18722008
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
E Latz, A Schoenemeyer, A Visintin, KA Fitzgerald, BG Monks, CF Knetter, ...
Nature immunology 5 (2), 190-198, 2004
14662004
Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
A Yoshimura, E Lien, RR Ingalls, E Tuomanen, R Dziarski, D Golenbock
The Journal of Immunology 163 (1), 1-5, 1999
14411999
LPS-TLR4 signaling to IRF-3/7 and NF-κB involves the toll adapters TRAM and TRIF
KA Fitzgerald, DC Rowe, BJ Barnes, DR Caffrey, A Visintin, E Latz, ...
The Journal of experimental medicine 198 (7), 1043-1055, 2003
13582003
The history of Toll-like receptors—redefining innate immunity
LAJ O'neill, D Golenbock, AG Bowie
Nature Reviews Immunology 13 (6), 453-460, 2013
13482013
Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
J Tian, AM Avalos, SY Mao, B Chen, K Senthil, H Wu, P Parroche, ...
Nature immunology 8 (5), 487-496, 2007
13472007
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
MT Heneka, MP Kummer, A Stutz, A Delekate, S Schwartz, ...
Nature 493 (7434), 674-678, 2013
13092013
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
CR Stewart, LM Stuart, K Wilkinson, JM Van Gils, J Deng, A Halle, ...
Nature immunology 11 (2), 155, 2010
11982010
Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
E Lien, TJ Sellati, A Yoshimura, TH Flo, G Rawadi, RW Finberg, ...
Journal of Biological Chemistry 274 (47), 33419-33425, 1999
11251999
Human toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
TK Means, S Wang, E Lien, A Yoshimura, DT Golenbock, MJ Fenton
The Journal of Immunology 163 (7), 3920-3927, 1999
10371999
Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
CJ Chen, H Kono, D Golenbock, G Reed, S Akira, KL Rock
Nature medicine 13 (7), 851-856, 2007
9422007
Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
TK Means, E Latz, F Hayashi, MR Murali, DT Golenbock, AD Luster
The Journal of clinical investigation 115 (2), 407-417, 2005
8702005
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
E Lien, TK Means, H Heine, A Yoshimura, S Kusumoto, K Fukase, ...
The Journal of clinical investigation 105 (4), 497-504, 2000
8632000
HMGB1 signals through toll-like receptor (TLR) 4 and TLR2
M Yu, H Wang, A Ding, DT Golenbock, E Latz, CJ Czura, MJ Fenton, ...
Shock 26 (2), 174-179, 2006
8212006
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
R Malley, P Henneke, SC Morse, MJ Cieslewicz, M Lipsitch, ...
Proceedings of the National Academy of Sciences 100 (4), 1966-1971, 2003
7772003
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