| The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ... Immunity 39 (3), 443-453, 2013 | 1137 | 2013 |
| Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ... Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014 | 554 | 2014 |
| MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ... Nature communications 11 (1), 3151, 2020 | 217 | 2020 |
| EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation JS Pearson, C Giogha, S Mühlen, U Nachbur, CLL Pham, Y Zhang, ... Nature microbiology 2 (4), 1-10, 2017 | 175 | 2017 |
| Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis EJ Petrie, JJ Sandow, AV Jacobsen, BJ Smith, MDW Griffin, IS Lucet, ... Nature communications 9 (1), 2422, 2018 | 173 | 2018 |
| HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death AV Jacobsen, KN Lowes, MC Tanzer, IS Lucet, JM Hildebrand, EJ Petrie, ... Cell death & disease 7 (1), e2051-e2051, 2016 | 154 | 2016 |
| Convergent evolution of receptors for protein import into mitochondria AJ Perry, JM Hulett, VA Likić, T Lithgow, PR Gooley Current Biology 16 (3), 221-229, 2006 | 138 | 2006 |
| A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production U Nachbur, CA Stafford, A Bankovacki, Y Zhan, LM Lindqvist, BK Fiil, ... Nature communications 6 (1), 6442, 2015 | 124 | 2015 |
| A BAFF-R mutation associated with non-Hodgkin lymphoma alters TRAF recruitment and reveals new insights into BAFF-R signaling JM Hildebrand, Z Luo, MK Manske, T Price-Troska, SC Ziesmer, W Lin, ... Journal of Experimental Medicine 207 (12), 2569-2579, 2010 | 122 | 2010 |
| The transmembrane segment of Tom20 is recognized by Mim1 for docking to the mitochondrial TOM complex JM Hulett, F Lueder, NC Chan, AJ Perry, P Wolynec, VA Likić, PR Gooley, ... Journal of molecular biology 376 (3), 694-704, 2008 | 118 | 2008 |
| Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions JM Hildebrand, Z Yi, CM Buchta, J Poovassery, LL Stunz, GA Bishop Immunological reviews 244 (1), 55-74, 2011 | 115 | 2011 |
| Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL JM Murphy, IS Lucet, JM Hildebrand, MC Tanzer, SN Young, P Sharma, ... Biochemical Journal 457 (3), 369-377, 2014 | 108 | 2014 |
| Evolutionary divergence of the necroptosis effector MLKL MC Tanzer, I Matti, JM Hildebrand, SN Young, A Wardak, A Tripaydonis, ... Cell Death & Differentiation 23 (7), 1185-1197, 2016 | 105 | 2016 |
| Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop MC Tanzer, A Tripaydonis, AI Webb, SN Young, LN Varghese, C Hall, ... Biochemical Journal 471 (2), 255-265, 2015 | 104 | 2015 |
| Protein import into mitochondria: origins and functions today R Lister, JM Hulett, T Lithgow, J Whelan Molecular membrane biology 22 (1-2), 87-100, 2005 | 104 | 2005 |
| Insane in the membrane: a structural perspective of MLKL function in necroptosis EJ Petrie, JM Hildebrand, JM Murphy Immunology and cell biology 95 (2), 152-159, 2017 | 77 | 2017 |
| Necroptotic signaling is primed in Mycobacterium tuberculosis-infected macrophages, but its pathophysiological consequence in disease is restricted MD Stutz, S Ojaimi, C Allison, S Preston, P Arandjelovic, JM Hildebrand, ... Cell Death & Differentiation 25 (5), 951-965, 2018 | 73 | 2018 |
| A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs S Murai, Y Yamaguchi, Y Shirasaki, M Yamagishi, R Shindo, ... Nature communications 9 (1), 4457, 2018 | 72 | 2018 |
| A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction JM Hildebrand, M Kauppi, IJ Majewski, Z Liu, AJ Cox, S Miyake, EJ Petrie, ... Nature communications 11 (1), 3150, 2020 | 69 | 2020 |
| Environmental stresses inhibit and stimulate different protein import pathways in plant mitochondria NL Taylor, C Rudhe, JM Hulett, T Lithgow, E Glaser, DA Day, AH Millar, ... FEBS letters 547 (1-3), 125-130, 2003 | 65 | 2003 |
John SilkeProfessor, The Walter and Eliza Hall InstituteVerified email at latrobe.edu.au
