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Jan Paulo T. Zaragoza
Jan Paulo T. Zaragoza
Senior Scientist, Merck
E-mail confirmado em merck.com
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Biomimetic reactivity of oxygen-derived manganese and iron porphyrinoid complexes
RA Baglia, JPT Zaragoza, DP Goldberg
Chemical reviews 117 (21), 13320-13352, 2017
2712017
Direct observation of oxygen rebound with an iron-hydroxide complex
JPT Zaragoza, TH Yosca, MA Siegler, P Moënne-Loccoz, MT Green, ...
Journal of the American Chemical Society 139 (39), 13640-13643, 2017
892017
A Reactive Manganese (IV)–Hydroxide Complex: A Missing Intermediate in Hydrogen Atom Transfer by High-Valent Metal-Oxo Porphyrinoid Compounds
JPT Zaragoza, MA Siegler, DP Goldberg
Journal of the American Chemical Society 140 (12), 4380-4390, 2018
502018
Strong Inhibition of O-Atom Transfer Reactivity for MnIV(O)(π-Radical-Cation)(Lewis Acid) versus MnV(O) Porphyrinoid Complexes
JPT Zaragoza, RA Baglia, MA Siegler, DP Goldberg
Journal of the American Chemical Society 137 (20), 6531-6540, 2015
502015
Detecting and characterizing the kinetic activation of thermal networks in proteins: Thermal transfer from a distal, solvent-exposed loop to the active site in soybean lipoxygenase
JPT Zaragoza, A Nguy, N Minnetian, Z Deng, AT Iavarone, ...
The Journal of Physical Chemistry B 123 (41), 8662-8674, 2019
302019
Hydroxyl Transfer to Carbon Radicals by Mn (OH) vs Fe (OH) Corrole Complexes
DC Cummins, JG Alvarado, JPT Zaragoza, MQ Effendy Mubarak, YT Lin, ...
Inorganic chemistry 59 (21), 16053-16064, 2020
262020
Hydrogen atom abstraction by high-valent Fe (OH) versus Mn (OH) porphyrinoid complexes: mechanistic insights from experimental and computational studies
JPT Zaragoza, DC Cummins, MQE Mubarak, MA Siegler, SP de Visser, ...
Inorganic chemistry 58 (24), 16761-16770, 2019
242019
Rhenium (v)–oxo corrolazines: isolating redox-active ligand reactivity
JPT Zaragoza, MA Siegler, DP Goldberg
Chemical communications 52 (1), 167-170, 2016
202016
The Influence of Peripheral Substituent Modification on PV, MnIII, and MnV(O) Corrolazines: X-ray Crystallography, Electrochemical and Spectroscopic Properties …
EE Joslin, JPT Zaragoza, RA Baglia, MA Siegler, DP Goldberg
Inorganic chemistry 55 (17), 8646-8660, 2016
192016
Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/decarboxylase
R Jonnalagadda, ADR Flores, W Cai, R Mehmood, M Narayanamoorthy, ...
Journal of Biological Chemistry 296, 2021
172021
Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase
JPT Zaragoza, AR Offenbacher, S Hu, CL Gee, ZM Firestein, N Minnetian, ...
Proceedings of the National Academy of Sciences 120 (10), e2211630120, 2023
162023
From Enantioselective to Regiodivergent Epoxide Opening and Radical Arylation–Useful or Just Interesting?
A Gansäuer
Synlett 32 (05), 447-456, 2021
142021
Dioxygen binding and activation mediated by transition metal porphyrinoid complexes
JPT Zaragoza, DP Goldberg
142018
Dioxygen-dependent Heme Enzymes
JPT Zaragoza, DP Goldberg
The Royal Society of Chemistry, 2019
112019
Temporal and spatial resolution of a protein quake that activates hydrogen tunneling in soybean lipoxygenase
JPT Zaragoza, AR Offenbacher, S Hu, CL Gee, ZM Firestein, N Minnetian, ...
bioRxiv, 2022.03. 31.486235, 2022
42022
meso-N-Methylation of a porphyrinoid complex: activating the H-atom transfer capability of an inert Re V (O) corrolazine
EE Joslin, JPT Zaragoza, MA Siegler, DP Goldberg
Chemical Communications 53 (12), 1961-1964, 2017
32017
Emerging Experimental Probes for the Spatial and Temporal Resolution of Protein Dynamics in Enzyme Catalysis
J Klinman, S Gao, EJ Thompson, JP Zaragoza
Biophysical Journal 120 (3), 100a, 2021
2021
Mononuclear high-valent Fe (OH) and Mn (OH) corroles
D Goldberg, JP Zaragoza
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018
2018
Employing novel porphyrinoid ligands to access biomimetic manganese and iron complexes of relevance to O2-activating heme enzymes
D Goldberg, JP Zaragoza, R Baglia, J Sacramento
Abstracts of Papers of the American Chemical Society 253, 2017
2017
meso-N-Methylation of a porphyrinoid complex: activating the H-atom transfer capability of an inert Reⱽ (O) corrolazine
JPT Zaragoza, MA Siegler, DP Goldberg
Chemical communications 53 (12), 2017
2017
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Artigos 1–20