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David W. Kastner
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MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate
AS Ireland, AM Micinski, DW Kastner, B Guo, SJ Wait, KB Spainhower, ...
Cancer cell 38 (1), 60-78. e12, 2020
3072020
Engineering of serine protease for improved thermostability and catalytic activity using rational design
NM Ashraf, A Krishnagopal, A Hussain, D Kastner, AMM Sayed, YK Mok, ...
International journal of biological macromolecules 126, 229-237, 2019
652019
MOFSimplify, machine learning models with extracted stability data of three thousand metal–organic frameworks
A Nandy, G Terrones, N Arunachalam, C Duan, DW Kastner, HJ Kulik
Scientific Data 9 (1), 74, 2022
572022
ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer
RR Olsen, AS Ireland, DW Kastner, SM Groves, KB Spainhower, K Pozo, ...
Genes & Development 35 (11-12), 847-869, 2021
382021
Humanin induces conformational changes in the apoptosis regulator BAX and sequesters it into fibers, preventing mitochondrial outer-membrane permeabilization
DL Morris, DW Kastner, S Johnson, MP Strub, Y He, CKE Bleck, DY Lee, ...
Journal of Biological Chemistry 294 (50), 19055-19065, 2019
332019
Using Computational Chemistry To Reveal Nature’s Blueprints for Single-Site Catalysis of C–H Activation
A Nandy, H Adamji, DW Kastner, V Vennelakanti, A Nazemi, M Liu, ...
ACS Catalysis 12 (15), 9281-9306, 2022
232022
Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310-Helical Peptides
D Joaquin, MA Lee, DW Kastner, J Singh, ST Morrill, G Damstedt, ...
The Journal of organic chemistry 85 (3), 1601-1613, 2019
202019
Bulky dehydroamino acids enhance proteolytic stability and folding in β-hairpin peptides
A Jalan, DW Kastner, KGI Webber, MS Smith, JL Price, SL Castle
Organic letters 19 (19), 5190-5193, 2017
192017
Mechanistic insights into substrate positioning that distinguish non-heme Fe (II)/α-ketoglutarate-dependent halogenases and hydroxylases
DW Kastner, A Nandy, R Mehmood, HJ Kulik
ACS Catalysis 13 (4), 2489-2501, 2023
142023
Influence of the greater protein environment on the electrostatic potential in metalloenzyme active sites: the case of formate dehydrogenase
A Nazemi, AH Steeves, DW Kastner, HJ Kulik
The Journal of Physical Chemistry B 126 (22), 4069-4079, 2022
122022
Probing the mechanism of isonitrile formation by a non-heme iron (II)-dependent oxidase/decarboxylase
A Del Rio Flores, DW Kastner, Y Du, M Narayanamoorthy, Y Shen, W Cai, ...
Journal of the American Chemical Society 144 (13), 5893-5901, 2022
122022
Potential involvement of mi-RNA 574-3p in progression of prostate cancer: A bioinformatic study
NM Ashraf, K Imran, DW Kastner, K Ikram, A Mushtaq, A Hussain, ...
Molecular and cellular probes 36, 21-28, 2017
122017
Emergence of a proton exchange-based isomerization and lactonization mechanism in the plant coumarin synthase COSY
CY Kim, AJ Mitchell, DW Kastner, CE Albright, MA Gutierrez, ...
Nature Communications 14 (1), 597, 2023
112023
Active Learning Exploration of Transition-Metal Complexes to Discover Method-Insensitive and Synthetically Accessible Chromophores
C Duan, A Nandy, GG Terrones, DW Kastner, HJ Kulik
JACS Au 3 (2), 391-401, 2022
82022
Synthesis and evaluation of potent yaku'amide A analogs
CCL Lo, D Joaquin, DA Moyá, A Ramos, DW Kastner, SM White, ...
Chemical Science 13 (7), 1899-1905, 2022
32022
Protein3D: Enabling analysis and extraction of metal‐containing sites from the Protein Data Bank with molSimplify
F Edholm, A Nandy, CR Reinhardt, DW Kastner, HJ Kulik
Journal of Computational Chemistry 45 (6), 352-361, 2024
12024
ASCL1 represses a latent osteogenic program in small cell lung Cancer in multiple cells of origin
RR Olsen, DW Kastner, AS Ireland, SM Groves, K Pozo, CP Whitney, ...
bioRxiv, 2020.11. 11.362632, 2020
12020
IA21 ASCL1 represses a latent osteogenic program in small-cell lung cancer arising from multiple cells of origin
RR Olsen, DW Kastner, AS Ireland, K Pozo, CP Whitney, MR Guthrie, ...
Journal of Thoracic Oncology 15 (2), S7, 2020
12020
Dynamic Charge Distribution as a Key Driver of Catalytic Reactivity in an Artificial Metalloenzyme
D Kastner, C Reinhardt, H Adamji, M Manetsch, Y Román-Leshkov, ...
2024
Structure and Dynamics Perspectives on Enzyme Function Probing the mechanism of isonitrile formation by a non-heme iron (II)-dependent oxidase/decarboxylase
ADR Flores, D Kastner, W Zhang
PROTEIN SCIENCE 32, 2023
2023
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