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Alex Rafacho
Alex Rafacho
Professor de Fisiologia Humana, Depto. de Ciências Fisiológicas, Centro de Ciências Biológicas
E-mail confirmado em ufsc.br
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Glucocorticoid treatment and endocrine pancreas function: implications for glucose homeostasis, insulin resistance and diabetes
A Rafacho, H Ortsäter, A Nadal, I Quesada
J Endocrinol 223 (3), R49-R62, 2014
2312014
High doses of dexamethasone induce increased β-cell proliferation in pancreatic rat islets
A Rafacho, TM Cestari, SR Taboga, AC Boschero, JR Bosqueiro
American Journal of Physiology-Endocrinology and Metabolism 296 (4), E681-E689, 2009
1322009
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans
SY Romero-Zerbo, A Rafacho, A Diaz-Arteaga, J Suárez, I Quesada, ...
Journal of endocrinology 211 (2), 177, 2011
1222011
Functional alterations in endocrine pancreas of rats with different degrees of dexamethasone-induced insulin resistance
A Rafacho, VAG Giozzet, AC Boschero, JR Bosqueiro
Pancreas 36 (3), 284-293, 2008
992008
Glucocorticoids in Vivo Induce Both Insulin Hypersecretion and Enhanced Glucose Sensitivity of Stimulus-Secretion Coupling in Isolated Rat Islets
A Rafacho, L Marroqui, SR Taboga, JLF Abrantes, LR Silveira, ...
Endocrinology 151 (1), 85-95, 2010
962010
Dexamethasone-induced insulin resistance is associated with increased connexin 36 mRNA and protein expression in pancreatic rat islets
A Rafacho, LP Roma, SR Taboga, AC Boschero, JR Bosqueiro
Canadian journal of physiology and pharmacology 85 (5), 536-545, 2007
942007
Impact of glucocorticoid excess on glucose tolerance: clinical and preclinical evidence
AM Pasieka, A Rafacho
Metabolites 6 (3), 24, 2016
932016
Exercise training prevents hyperinsulinemia, muscular glycogen loss and muscle atrophy induced by dexamethasone treatment
M Barel, OAB Perez, VA Giozzet, A Rafacho, JR Bosqueiro, SL do Amaral
European journal of applied physiology 108, 999-1007, 2010
922010
Morphofunctional alterations in endocrine pancreas of short-and long-term dexamethasone-treated rats
A Rafacho, JLF Abrantes, DL Ribeiro, FM Paula, ME Pinto, AC Boschero, ...
Hormone and Metabolic Research 43 (04), 275-281, 2011
872011
Glargine vs. NPH insulin therapy in pregnancies complicated by diabetes: an observational cohort study
CA Negrato, A Rafacho, G Negrato, MF Teixeira, CAR Araújo, L Vieira, ...
diabetes research and clinical practice 89 (1), 46-51, 2010
842010
Implications of palmitoleic acid (palmitoleate) on glucose homeostasis, insulin resistance and diabetes
E Araujo Nunes, A Rafacho
Current drug targets 18 (6), 619-628, 2017
592017
High‐fat diet obesity associated with insulin resistance increases cell proliferation, estrogen receptor, and PI3K proteins in rat ventral prostate
DL Ribeiro, ME Pinto, A Rafacho, JR Bosqueiro, SY Maeda, ...
Journal of andrology 33 (5), 854-865, 2012
532012
The adaptive compensations in endocrine pancreas from glucocorticoid‐treated rats are reversible after the interruption of treatment
A Rafacho, S Quallio, DL Ribeiro, SR Taboga, FMM Paula, AC Boschero, ...
Acta physiologica 200 (3), 223-235, 2010
532010
Increased pancreatic islet mass is accompanied by activation of the insulin receptor substrate‐2/serine‐threonine kinase pathway and augmented cyclin D2 protein …
A Rafacho, DL Ribeiro, AC Boschero, SR Taboga, JR Bosqueiro
International journal of experimental pathology 89 (4), 264-275, 2008
522008
Augmentation of insulin secretion by leucine supplementation in malnourished rats: possible involvement of the phosphatidylinositol 3-phosphate kinase/mammalian target protein …
E Filiputti, A Rafacho, EP Araújo, LR Silveira, A Trevisan, TM Batista, ...
Metabolism 59 (5), 635-644, 2010
512010
Hyperinsulinemia caused by dexamethasone treatment is associated with reduced insulin clearance and lower hepatic activity of insulin-degrading enzyme
AOP Protzek, LF Rezende, JM Costa-Júnior, SM Ferreira, APG Cappelli, ...
The journal of steroid biochemistry and molecular biology 155, 1-8, 2016
502016
Pancreatic alpha-cell dysfunction contributes to the disruption of glucose homeostasis and compensatory insulin hypersecretion in glucocorticoid-treated rats
A Rafacho, LM Goncalves-Neto, JC Santos-Silva, P Alonso-Magdalena, ...
PLoS One 9 (4), e93531, 2014
462014
Prostate hyperplasia caused by long‐term obesity is characterized by high deposition of extracellular matrix and increased content of MMP‐9 and VEGF
SA Silva, MG Gobbo, ME Pinto‐Fochi, A Rafacho, SR Taboga, ...
International journal of experimental pathology 96 (1), 21-30, 2015
432015
Reduced insulin secretion in protein malnourished mice is associated with multiple changes in the β-cell stimulus-secretion coupling
S Soriano, A Gonzalez, L Marroquí, E Tudurí, E Vieira, AG Amaral, ...
Endocrinology 151 (8), 3543-3554, 2010
432010
Augmented β-cell function and mass in glucocorticoid-treated rodents are associated with increased islet Ir-β/AKT/mTOR and decreased AMPK/ACC and AS160 signaling
AOP Protzek, JM Costa-Júnior, LF Rezende, GJ Santos, TG Araújo, ...
International journal of endocrinology 2014, 2014
412014
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